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Medicine

D-Index
88
Citations
35283
World Ranking
12990
National Ranking
531

Overview

David W. Hedley is affiliated with the Princess Margaret Cancer Centre in Canada. Their research primarily focuses on Medicine and Biochemistry, Genetics and Molecular Biology, with a particular emphasis on Oncology, Cancer Research, Molecular Biology, Surgery, and Radiology, Nuclear Medicine, and Imaging.

The main topics addressed in their work include:

  • Cancer, Hypoxia, and Metabolism
  • Pancreatic and Hepatic Oncology Research
  • Cancer Research and Treatments
  • Transplantation: Methods and Outcomes
  • Glioma Diagnosis and Treatment
  • Radiopharmaceutical Chemistry and Applications
  • Cytomegalovirus and herpesvirus research

The scientist has published frequently in the following venues:

  • The Journal of Heart and Lung Transplantation
  • Neuro-Oncology
  • Scientific Reports
  • Science Advances
  • Cytotherapy

Recent papers authored or coauthored by David W. Hedley include:

  • A phase II trial of GSK2256098 and trametinib in patients with advanced pancreatic ductal adenocarcinoma (2022), Journal of Gastrointestinal Oncology
  • Patient-derived tumor xenograft and organoid models established from resected pancreatic, duodenal and biliary cancers (2021), Scientific Reports
  • Quantifying Reoxygenation in Pancreatic Cancer During Stereotactic Body Radiotherapy (2020), Scientific Reports
  • NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4 (2021), Science Advances
  • Pancreatic cancer growth promoted by bone marrow mesenchymal stromal cell-derived IL-6 is reversed predominantly by IL-6 blockade (2022), Cytotherapy

Frequent collaborators include:

  • May Cheung
  • Anna Dvorkin-Gheva
  • Sajad Moshkelgosha
  • Tereza Martinu
  • Bradly G. Wouters

Best Publications

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry

    D W Hedley;M L Friedlander;I W Taylor;C A Rugg

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Mübeccel Akdis

  • Patterns of somatic structural variation in human cancer genomes

    Yilong Li;Nicola D Roberts;Jeremiah A Wala;Jeremiah A Wala;Ofer Shapira;Ofer Shapira

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  • Guidelines for implementation of clinical DNA cytometry

    T V Shankey;P S Rabinovitch;B Bagwell;K D Bauer

  • The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors.

    Andrew J. Primeau;Augusto Rendon;David Hedley;Lothar Lilge

  • Clinical and biological significance of aneuploidy in human tumours.

    M L Friedlander;D W Hedley;I W Taylor

  • Tumor Hypoxia Has Independent Predictor Impact Only in Patients With Node-Negative Cervix Cancer

    A. Fyles;M. Milosevic;D. Hedley;M. Pintilie

  • Application of DNA flow cytometry to paraffin‐embedded archival material for the study of aneuploidy and its clinical significance

    David W. Hedley;Michael L. Friedlander;Ian W. Taylor

  • Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial

    Kyaw Lwin Aung;Sandra E Fischer;Sandra E Fischer;Robert E Denroche;Gun-Ho Jang

  • Guidelines for the implementation of clinical DNA cytometry

    T. Vincent Shankey;Peter S. Rabinovitch;Bruce Bagwell;Kenneth D. Bauer

  • Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers.

    T D Golan;Zaheer S Kanji;Ron Epelbaum;N Devaud;N Devaud

  • Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells.

    Sylvia S. W. Ng;Ming-Sound Tsao;Sue Chow;David W. Hedley

  • Germline BRCA Mutations in a Large Clinic-Based Cohort of Patients With Pancreatic Adenocarcinoma

    Spring Holter;Ayelet Borgida;Anna Dodd;Robert Grant

  • Down-Regulation of Rad51 and Decreased Homologous Recombination in Hypoxic Cancer Cells

    Ranjit S. Bindra;Paul J. Schaffer;Alice Meng;Jennifer Woo

  • Influence of cellular DNA content on survival in advanced ovarian cancer.

    Michael L. Friedlander;David W. Hedley;Ian W. Taylor;Peter Russell

  • Combining Gemcitabine and Capecitabine in Patients With Advanced Biliary Cancer: A Phase II Trial

    Jennifer J. Knox;David Hedley;Amit Oza;Ron Feld

  • Flow cytometry using paraffin-embedded tissue: five years on

    David W. Hedley

  • A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas.

    Duran I;Kortmansky J;Singh D;Hirte H

Frequent Co-Authors

Richard P. Hill
Richard P. Hill Princess Margaret Cancer Centre
Ming-Sound Tsao
Ming-Sound Tsao Princess Margaret Cancer Centre
Malcolm J. Moore
Malcolm J. Moore Princess Margaret Cancer Centre
Melania Pintilie
Melania Pintilie Princess Margaret Cancer Centre
Michael Milosevic
Michael Milosevic Princess Margaret Cancer Centre
Anthony Fyles
Anthony Fyles Princess Margaret Cancer Centre
Aaron D. Schimmer
Aaron D. Schimmer Princess Margaret Cancer Centre
Amit M. Oza
Amit M. Oza Princess Margaret Cancer Centre
Mark D. Minden
Mark D. Minden Princess Margaret Cancer Centre
Bradly G. Wouters
Bradly G. Wouters Princess Margaret Cancer Centre

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