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Medicine

D-Index
112
Citations
56365
World Ranking
5085
National Ranking
199

Overview

Mark D. Minden is affiliated with the Princess Margaret Cancer Centre in Canada and has an extensive publication record focused primarily on hematology and cancer research. Their research spans multiple interconnected fields, including medicine, biochemistry, genetics, and molecular biology, emphasizing hematology, molecular biology, cancer research, genetics, and oncology.

The main topics covered in their work include:

  • Acute Myeloid Leukemia Research
  • Chronic Myeloid Leukemia Treatments
  • Acute Lymphoblastic Leukemia research
  • Cancer Genomics and Diagnostics
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Histone Deacetylase Inhibitors Research
  • Epigenetics and DNA Methylation

Mark D. Minden has contributed to several recent publications in high-impact journals, reflecting ongoing investigations into acute myeloid leukemia and related hematologic malignancies. Recent papers include:

  • A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia, 2022, Nature Medicine
  • Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia, 2020, Science Translational Medicine
  • CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells, 2020, Blood
  • Phase I Study of the CD47 Blocker TTI-621 in Patients with Relapsed or Refractory Hematologic Malignancies, 2021, Clinical Cancer Research
  • Venetoclax enhances T cell-mediated antileukemic activity by increasing ROS production, 2021, Blood

Frequent collaborators in their research include:

  • Andrea Arruda
  • Aaron D. Schimmer
  • Steven M. Chan
  • John E. Dick
  • Hassan Sibai

Their work is published predominantly in the following venues:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Haematologica
  • Blood Cancer Discovery

Best Publications

  • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

    Tsvee Lapidot;Christian Sirard;Josef Vormoor;Barbara Murdoch

  • Mll translocations specify a distinct gene expression profile, distinguishing a unique leukemia

    Todd R. Golub;Scott A. Armstrong;Stanley J. Korsmeyer

  • Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

    Liran I. Shlush;Sasan Zandi;Amanda Mitchell;Weihsu Claire Chen

  • Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia

    Hagop M. Kantarjian;Xavier G. Thomas;Anna Dmoszynska;Agnieszka Wierzbowska

  • International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts

    Hervé Dombret;John F. Seymour;Aleksandra Butrym;Agnieszka Wierzbowska

  • Stem cell gene expression programs influence clinical outcome in human leukemia

    Kolja Eppert;Katsuto Takenaka;Eric R Lechman;Levi Waldron

  • Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

    Stefan Gross;Rob A. Cairns;Mark D. Minden;Edward M. Driggers

  • A 17-gene stemness score for rapid determination of risk in acute leukaemia

    Stanley W. K. Ng;Amanda Mitchell;James A. Kennedy;James A. Kennedy;James A. Kennedy;Weihsu C. Chen

  • The genomic landscape of hypodiploid acute lymphoblastic leukemia

    Linda Holmfeldt;Lei Wei;Ernesto Diaz-Flores;Michael Walsh

  • Prediction of acute myeloid leukaemia risk in healthy individuals

    Sagi Abelson;Grace Collord;Grace Collord;Stanley W.K. Ng;Omer Weissbrod

  • Sensitive tumour detection and classification using plasma cell-free DNA methylomes

    Shu Yi Shen;Rajat Singhania;Gordon Fehringer;Ankur Chakravarthy

  • HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis

    W W L Wong;J Dimitroulakos;M D Minden;M D Minden;L Z Penn;L Z Penn

  • Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

    Tino Schenk;Weihsu Claire Chen;Stefanie Göllner;Louise Howell

  • Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

    Marko Škrtić;Shrivani Sriskanthadevan;Bozhena Jhas;Marinella Gebbia

  • A tumor suppressor and oncogene: the WT1 story

    L Yang;Y Han;F Saurez Saiz;M D Minden

  • Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

    Marcus Dühren-von Minden;Rudolf Übelhart;Dunja Schneider;Thomas Wossning

  • Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

    Faiyaz Notta;Faiyaz Notta;Charles G. Mullighan;Jean C. Y.Wang;Jean C. Y.Wang;Armando Poeppl

  • Tracing the origins of relapse in acute myeloid leukaemia to stem cells

    Liran I. Shlush;Liran I. Shlush;Amanda Mitchell;Lawrence Heisler;Sagi Abelson

  • A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects

    Yuki Kagoya;Shinya Tanaka;Tingxi Guo;Tingxi Guo;Mark Anczurowski;Mark Anczurowski

  • Corrigendum: Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

    Liran I. Shlush;Sasan Zandi;Amanda Mitchell;Weihsu Claire Chen

Frequent Co-Authors

Aaron D. Schimmer
Aaron D. Schimmer Princess Margaret Cancer Centre
Vikas Gupta
Vikas Gupta Princess Margaret Cancer Centre
John E. Dick
John E. Dick Princess Margaret Cancer Centre
Suzanne Kamel-Reid
Suzanne Kamel-Reid University Health Network
James A. Kennedy
James A. Kennedy Princess Margaret Cancer Centre
Gary D. Bader
Gary D. Bader University of Toronto
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Wei Xu
Wei Xu Shenzhen University
George Tomlinson
George Tomlinson University of Toronto
David W. Hedley
David W. Hedley Princess Margaret Cancer Centre

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