World's Best Scientists 2026 revealed!

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Biology and Biochemistry

D-Index
97
Citations
39404
World Ranking
1735
National Ranking
964

Medicine

D-Index
97
Citations
39272
World Ranking
9191
National Ranking
4741

Overview

Roy L. Silverstein is affiliated with the Medical College of Wisconsin in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, contributing significantly to subfields such as Molecular Biology, Epidemiology, Surgery, Cancer Research, and Immunology.

The scientist's work covers several main topics including:

  • Peroxisome Proliferator-Activated Receptors
  • Adipokines, Inflammation, and Metabolic Diseases
  • COVID-19 Clinical Research Studies
  • Lipoproteins and Cardiovascular Health
  • Ion Transport and Channel Regulation
  • Cancer, Hypoxia, and Metabolism
  • Angiogenesis and VEGF in Cancer

Among recent publications authored or co-authored by Silverstein are:

  • "CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors," 2020, Nature Immunology
  • "CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate," 2022, The Journal of Experimental Medicine
  • "Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer," 2021, Cancer Immunology Research
  • "Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk," 2020, UNC Libraries
  • "Intracellular tPA-PAI-1 interaction determines VLDL assembly in hepatocytes," 2023, Science

Roy L. Silverstein has collaborated frequently with several researchers, including:

  • Yiliang Chen (17 collaborations)
  • Wen Dai (10 collaborations)
  • Ze Zheng (10 collaborations)
  • Jue Zhang (8 collaborations)
  • Hayley Lund (7 collaborations)

The scientist's work has been published regularly in venues such as:

  • Blood Advances (5 publications)
  • Frontiers in Cardiovascular Medicine (3 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)
  • Circulation (2 publications)
  • SSRN Electronic Journal (2 publications)

Best Publications

  • Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.

    Weifei Zhu;Jill C. Gregory;Elin Org;Jennifer A. Buffa

  • Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes

    Matthew L. Albert;S.Frieda A. Pearce;Loise M. Francisco;Birthe Sauter

  • CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism

    Maria Febbraio;David P. Hajjar;Roy L. Silverstein

  • Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages

    Vidya V. Kunjathoor;Maria Febbraio;Eugene A. Podrez;Kathryn J. Moore

  • Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice

    Maria Febbraio;Eugene A. Podrez;Jonathan D. Smith;David P. Hajjar

  • Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1

    Benilde Jiménez;Olga V. Volpert;Susan E. Crawford;Maria Febbraio

  • CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

    Roy L. Silverstein;Maria Febbraio

  • CD36 Mediates the In Vitro Inhibitory Effects of Thrombospondin-1 on Endothelial Cells

    David W. Dawson;S. Frieda A. Pearce;Ruiqin Zhong;Roy L. Silverstein

  • A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism.

    Maria Febbraio;Nada A. Abumrad;David P. Hajjar;Kavita Sharma

  • Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice.

    Chris T. Coburn;F.F. Knapp;Maria Febbraio;Arnold L. Beets

  • Isolation of the thrombospondin membrane receptor.

    A S Asch;J Barnwell;R L Silverstein;R L Nachman

  • Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

    Jie Zhou;Maria Febbraio;Taira Wada;Yonggong Zhai

  • Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species

    Eugene A. Podrez;Maria Febbraio;Nader Sheibani;David Schmitt

  • A CD36-dependent signaling cascade is necessary for macrophage foam cell formation

    S. Ohidar Rahaman;David J. Lennon;David J. Lennon;Maria Febbraio;Evgeny A. Podrez

  • Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype

    Eugene A Podrez;Tatiana V Byzova;Maria Febbraio;Robert G Salomon

  • A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions.

    Eugene A. Podrez;Eugenia Poliakov;Zhongzhou Shen;Renliang Zhang

  • Activation of cultured vascular endothelial cells by antiphospholipid antibodies.

    Ronit Simantov;Johanna M. LaSala;Siu K. Lo;Azzudin E. Gharavi

  • CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis.

    Yi Ren;Roy L. Silverstein;Janet Allen;John Savill

  • CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima

    Young Mi Park;Maria Febbraio;Roy L. Silverstein

  • Oxidized phosphatidylserine–CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells

    Michael E. Greenberg;Mingjiang Sun;Renliang Zhang;Maria Febbraio

Frequent Co-Authors

Maria Febbraio
Maria Febbraio Cleveland Clinic
Paul I. W. de Bakker
Paul I. W. de Bakker Vertex Pharmaceuticals (United Kingdom)
David P. Hajjar
David P. Hajjar Cornell University
Stanley L. Hazen
Stanley L. Hazen Cleveland Clinic Lerner College of Medicine
Ralph L. Nachman
Ralph L. Nachman Cornell University
Nilesh J. Samani
Nilesh J. Samani University of Leicester
Alan R. Shuldiner
Alan R. Shuldiner University of Maryland, Baltimore
Patricia B. Munroe
Patricia B. Munroe Queen Mary University of London
Yun Li
Yun Li University of North Carolina at Chapel Hill
Hakon Hakonarson
Hakon Hakonarson Children's Hospital of Philadelphia

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