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Molecular Biology

D-Index
80
Citations
25806
World Ranking
993
National Ranking
525

Overview

Nada A. Abumrad is a researcher affiliated with Washington University in St. Louis in the United States. Their work spans primarily across biochemistry, genetics, molecular biology, and medicine. The scientist has contributed extensively to subfields such as molecular biology, physiology, immunology, cell biology, and cardiology and cardiovascular medicine.

The core themes of their research interest include adipose tissue and metabolism, lipid metabolism and biosynthesis, peroxisome proliferator-activated receptors, extracellular vesicles in disease, immune cells in cancer, adipokines, inflammation, and metabolic diseases, as well as caveolin-1 and cellular processes.

Recent publications by Nada A. Abumrad reflect a focus on lipid metabolism and immune system interactions, with notable papers including:

  • Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors, 2021, Immunity
  • Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood, 2022, Cell Metabolism
  • Endothelial Cell Receptors in Tissue Lipid Uptake and Metabolism, 2021, Circulation Research
  • Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells, 2021, Nature Communications
  • Fatty Acid Transport and Signaling: Mechanisms and Physiological Implications, 2022, Annual Review of Physiology

Frequent collaborators include Ira J. Goldberg, Terri Pietka, Dmitri Samovski, Ainara G. Cabodevilla, and Vivek S. Peche, indicating extensive teamwork and co-authorship within their field.

The scientist has published numerous articles in venues such as bioRxiv (Cold Spring Harbor Laboratory), Arteriosclerosis Thrombosis and Vascular Biology, Immunity, Nature Communications, and the Journal of Clinical Investigation.

Best Publications

  • Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36.

    N.A. Abumrad;M.R. el-Maghrabi;E.Z. Amri;E. Lopez

  • Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

    Stanley Ching Cheng Huang;Bart Everts;Yulia Ivanova;David O'Sullivan

  • Identification of Cd36 ( Fat ) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats

    Timothy J. Aitman;Anne M. Glazier;Caroline A. Wallace;Lisa D. Cooper

  • Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors.

    Shihao Xu;Omkar Chaudhary;Patricia Rodríguez-Morales;Xiaoli Sun

  • Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism

    Unknown

  • Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors.

    Ez-Zoubir Amri;Frédéric Bonino;Gérard Ailhaud;Nada A. Abumrad

  • Evidence against the presence of an anandamide transporter

    Unknown

  • Expression of the CD36 homolog (FAT) in fibroblast cells: effects on fatty acid transport

    Azeddine Ibrahimi;Zeina Sfeir;Hengameh Magharaie;Ez-Zoubir Amri

  • Inhibition of Foxo1 Protects Pancreatic Islet β-Cells Against Fatty Acid and Endoplasmic Reticulum Stress-Induced Apoptosis

    Unknown

  • Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats.

    Pravenec M;Landa;Zidek;Musilova A

  • A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians

    Xiaowei Ma;Simonetta Bacci;Wojciech Mlynarski;Lucia Gottardo

  • Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol.

    Latisha Love-Gregory;Richard Sherva;Lingwei Sun;Jon Wasson

  • Role of CD36 in membrane transport of long-chain fatty acids.

    Unknown

  • Genetic Ablation of Calcium-independent Phospholipase A2γ Leads to Alterations in Mitochondrial Lipid Metabolism and Function Resulting in a Deficient Mitochondrial Bioenergetic Phenotype

    David J. Mancuso;Harold F. Sims;Xianlin Han;Christopher M. Jenkins

  • Regulation of AMPK Activation by CD36 Links Fatty Acid Uptake to β-Oxidation

    Dmitri Samovski;Jingyu Sun;Terri Pietka;Richard W. Gross

  • Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile

    Latisha Love-Gregory;Richard Sherva;Timothy Schappe;Jian Shen Qi

  • Induction of aP2 gene expression by nonmetabolized long-chain fatty acids

    Unknown

  • Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase.

    Dmitri Samovski;Xiong Su;Yingcheng Xu;Nada A. Abumrad

  • CD36-dependent Regulation of Muscle FoxO1 and PDK4 in the PPARδ/β-mediated Adaptation to Metabolic Stress

    Zaher Nahlé;Michael Hsieh;Terri Pietka;Chris T. Coburn

  • Cell-intrinsic lysosomal lipolysis is essential for macrophage alternative activation

    Stanley Ching-Cheng Huang;Bart Everts;Yulia Ivanova;David O'Sullivan

Frequent Co-Authors

Samuel Klein
Samuel Klein Washington University in St. Louis
Ira J. Goldberg
Ira J. Goldberg New York University
Richard W. Gross
Richard W. Gross Washington University in St. Louis
Ez-Zoubir Amri
Ez-Zoubir Amri Grenoble Alpes University
Bruce W. Patterson
Bruce W. Patterson Washington University in St. Louis
Paul Grimaldi
Paul Grimaldi Université Côte d'Azur
Jan F. C. Glatz
Jan F. C. Glatz Maastricht University
Nicholas O. Davidson
Nicholas O. Davidson Washington University in St. Louis
Theodore W. Kurtz
Theodore W. Kurtz University of California, San Francisco
Vladimir Kren
Vladimir Kren Czech Academy of Sciences

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