World's Best Scientists 2026 revealed!
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Biology and Biochemistry
Czechia
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
22613
World Ranking
6553
National Ranking
6

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Czechia Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Genetics

The scientist’s investigation covers issues in Internal medicine, Endocrinology, Genetics, Spontaneously hypertensive rat and Quantitative trait locus. His research in Genome, Gene mapping and Genetic marker are components of Genetics. Vladimir Kren interconnects Genetic linkage and Inbred strain in the investigation of issues within Genome.

His research integrates issues of Carbohydrate metabolism and Insulin, Insulin resistance in his study of Spontaneously hypertensive rat. His Insulin resistance research includes elements of Fatty acid metabolism, Fatty acid, Abdominal obesity and CD36. His Quantitative trait locus study which covers Gene expression profiling that intersects with Regulation of gene expression, Transcriptome, Knockout mouse, Regulator and In vivo.

His most cited work include:

  • Identification of Cd36 ( Fat ) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats (693 citations)
  • Identification of Cd36 ( Fat ) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats (693 citations)
  • Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease (476 citations)

What are the main themes of his work throughout his whole career to date?

Vladimir Kren mostly deals with Genetics, Internal medicine, Endocrinology, Spontaneously hypertensive rat and Biochemistry. Quantitative trait locus, Gene, Genetic linkage, Gene mapping and Chromosome are subfields of Genetics in which his conducts study. The Quantitative trait locus study which covers Regulation of gene expression that intersects with Gene expression.

He has researched Genetic linkage in several fields, including Molecular biology, Human genetics and Candidate gene. His work investigates the relationship between Endocrinology and topics such as Congenic that intersect with problems in Allele and Transplantation. As part of one scientific family, Vladimir Kren deals mainly with the area of Spontaneously hypertensive rat, narrowing it down to issues related to the Inbred strain, and often Recombinant DNA and Phenotype.

He most often published in these fields:

  • Genetics (39.25%)
  • Internal medicine (37.38%)
  • Endocrinology (36.92%)

What were the highlights of his more recent work (between 2007-2020)?

  • Biochemistry (17.76%)
  • Internal medicine (37.38%)
  • Endocrinology (36.92%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Biochemistry, Internal medicine, Endocrinology, Spontaneously hypertensive rat and Stereochemistry. His Internal medicine study incorporates themes from Quantitative trait locus, Sucrose and Gene expression profiling. His Quantitative trait locus research entails a greater understanding of Genetics.

The Endocrinology study combines topics in areas such as Cancer, Protein kinase B and Cyclin D1. His biological study spans a wide range of topics, including Congenic, Cholesterol, Triglyceride, Chylomicron and Inbred strain. His Stereochemistry study combines topics in areas such as Hydrolase, Enzymatic synthesis and Fatty acid.

Between 2007 and 2020, his most popular works were:

  • Biodegradation potential of the genus Rhodococcus. (322 citations)
  • Integrated genomic approaches implicate osteoglycin ( Ogn ) in the regulation of left ventricular mass (141 citations)
  • Integrated genomic approaches implicate osteoglycin ( Ogn ) in the regulation of left ventricular mass (141 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Genetics

Vladimir Kren mainly focuses on Biochemistry, Endocrinology, Internal medicine, Biotransformation and Spontaneously hypertensive rat. His work in the fields of Endocrinology, such as Blood pressure, overlaps with other areas such as Expression quantitative trait loci. His Biotransformation study integrates concerns from other disciplines, such as Pharmacokinetics, Stereochemistry, Substrate and Herbal preparations.

His Stereochemistry research is multidisciplinary, incorporating elements of Lipid peroxidation, Antioxidant and Fatty acid. As a part of the same scientific study, he usually deals with the Spontaneously hypertensive rat, concentrating on Congenic and frequently concerns with Allele, Transplantation, Inbred strain and Kidney. His Quantitative trait locus research incorporates themes from Transcriptome, Gene expression, Gene expression profiling, Knockout mouse and Regulator.

Best Publications

  • Identification of Cd36 ( Fat ) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats

    Timothy J. Aitman;Anne M. Glazier;Caroline A. Wallace;Lisa D. Cooper

  • Silybin and silymarin--new and emerging applications in medicine.

    Radek Gazak;Daniela Walterova;Vladimir Kren

  • A genetic linkage map of the laboratory rat, Rattus norvegicus

    Howard J. Jacob;Howard J. Jacob;Donna M. Brown;Ruth K. Bunker;Mark J. Daly

  • Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease

    Norbert Hubner;Caroline A Wallace;Heike Zimdahl;Enrico Petretto

  • Glycosides in medicine: "The role of glycosidic residue in biological activity".

    Vladimir Kren;Ludmila Martinkova

  • Biodegradation potential of the genus Rhodococcus.

    Ludmila Martínková;Bronislava Uhnáková;Miroslav Pátek;Jan Nesvera

  • Silybin and silymarin - new effects and applications

    Vladimír Kren;Daniela Walterová

  • Heritability and Tissue Specificity of Expression Quantitative Trait Loci

    Enrico Petretto;Jonathan Mangion;Nicholas J Dickens;Stuart A Cook

  • An analysis of spontaneous hypertension in spontaneously hypertensive rats by means of new recombinant inbred strains.

    M Pravenec;P Klír;V Kren;J Zicha

  • Cosegregation of blood pressure with a kallikrein gene family polymorphism.

    M Pravenec;V Kren;J Kunes;A G Scicli

  • SNP and haplotype mapping for genetic analysis in the rat

    Kathrin Saar;Alfred Beck;Marie-Thérèse Bihoreau;Ewan Birney

  • Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains.

    M Pravenec;D Gauguier;J J Schott;J Buard

  • Integrated genomic approaches implicate osteoglycin ( Ogn ) in the regulation of left ventricular mass

    Enrico Petretto;Rizwan Sarwar;Ian Grieve;Han Lu

  • β-N-Acetylhexosaminidase: What's in a name…?

    Kristýna Slámová;Pavla Bojarová;Lucie Petrásková;Vladimír Kren

  • Biotransformations with nitrilases

    Ludmila Martínková;Vladimír Kren

  • A genetic linkage map of the rat derived from recombinant inbred strains.

    M Pravenec;D Gauguier;J J Schott;J Buard

  • Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension

    Michal Pravenec;Michal Pravenec;Vaclav Zidek;Miroslava Simakova;Vladimir Kren;Vladimir Kren

  • Genetic susceptibility to hypertension-induced renal damage in the rat. Evidence based on kidney-specific genome transfer.

    P C Churchill;M C Churchill;A K Bidani;K A Griffin

  • Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

    Michal Pravenec;Michal Pravenec;Paul C Churchill;Monique C Churchill;Ondrej Viklicky

  • Use of AFLP markers for gene mapping and QTL detection in the rat

    M. Otsen;M. Den Bieman;M. T. R. Kuiper;M. Pravenec

Frequent Co-Authors

Michal Pravenec
Michal Pravenec Czech Academy of Sciences
Theodore W. Kurtz
Theodore W. Kurtz University of California, San Francisco
Timothy J. Aitman
Timothy J. Aitman University of Edinburgh
Jitka Ulrichová
Jitka Ulrichová Palacký University, Olomouc
Pavel Hamet
Pavel Hamet University of Montreal
Vilím Šimánek
Vilím Šimánek Palacký University, Olomouc
Enrico Petretto
Enrico Petretto Duke NUS Graduate Medical School
Claude Szpirer
Claude Szpirer Université Libre de Bruxelles
Stuart A. Cook
Stuart A. Cook Duke NUS Graduate Medical School
Norbert Hubner
Norbert Hubner Max Delbrück Center for Molecular Medicine

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