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Medicine

D-Index
91
Citations
32056
World Ranking
11715
National Ranking
34

Overview

Stuart A. Cook is affiliated with the National University of Singapore in Singapore. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, with a particular focus on cardiology and cardiovascular medicine as well as molecular biology and genetics.

The primary research topics addressed by Cook include:

  • Cardiomyopathy and Myosin Studies
  • Congenital heart defects research
  • Cardiovascular Function and Risk Factors
  • Genetic Associations and Epidemiology
  • Genomics and Rare Diseases
  • Cardiac Fibrosis and Remodeling
  • Liver Disease Diagnosis and Treatment

Cook's work has appeared extensively in several prominent publication venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory) with 29 publications
  • Nature Communications with 8 publications
  • Circulation with 6 publications
  • Nature Genetics with 5 publications
  • Journal of the American College of Cardiology with 5 publications

Among recent significant papers are:

  • Whole-genome sequencing of patients with rare diseases in a national health system, 2020, Nature
  • Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect, 2021, Nature Genetics
  • Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy, 2020, Circulation
  • Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?, 2020, EMBO Molecular Medicine
  • LifeTime and improving European healthcare through cell-based interceptive medicine, 2020, Nature

Frequent co-authors collaborating with Cook include:

  • Anissa A. Widjaja
  • Paul J.R. Barton
  • James S. Ware
  • Declan P. O'Regan
  • Chee Jian Pua

Cook's research largely intersects clinical cardiology and molecular genetics, particularly focusing on genetic cardiomyopathies and the molecular mechanisms underlying cardiovascular diseases. This multidisciplinary work integrates genomics, clinical observations, and molecular biology approaches to better understand cardiovascular risk factors and disease progression.

Their research contributions also extend to the study of cardiac fibrosis and remodeling, with implications for heart failure and congenital heart defects, as well as the genetic underpinnings of rare diseases identifiable through advanced genomic sequencing technologies.

Best Publications

  • Truncations of Titin Causing Dilated Cardiomyopathy

    Daniel S. Herman;Lien Lam;Matthew R.G. Taylor;Libin Wang

  • Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy.

    Ankur Gulati;Andrew Jabbour;Tevfik F. Ismail;Kaushik Guha

  • Anatomically Constrained Neural Networks (ACNNs): Application to Cardiac Image Enhancement and Segmentation

    Ozan Oktay;Enzo Ferrante;Konstantinos Kamnitsas;Mattias Heinrich

  • Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples

    Roddy Walsh;Kate L. Thomson;James S. Ware;James S. Ware;Birgit H. Funke

  • Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease

    Norbert Hubner;Caroline A Wallace;Heike Zimdahl;Enrico Petretto

  • Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

    John Travis Hinson;Anant Chopra;N. Nafissi;William Polacheck;William Polacheck

  • Midwall Fibrosis Is an Independent Predictor of Mortality in Patients With Aortic Stenosis

    Marc R. Dweck;Sanjiv Joshi;Timothy Murigu;Francisco Alpendurada

  • Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies

    J.S. Ware;J. Li;E. Mazaika;C.M. Yasso

  • IL-11 is a crucial determinant of cardiovascular fibrosis

    Sebastian Schafer;Sivakumar Viswanathan;Anissa A Widjaja;Wei-Wen Lim

  • Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial

    Brian P Halliday;Rebecca Wassall;Amrit S Lota;Zohya Khalique

  • Phenotypic Spectrum Caused by Transgenic Overexpression of Activated Akt in the Heart

    Takashi Matsui;Ling Li;Justina C. Wu;Stuart Cook

  • The Diagnosis and Evaluation of Dilated Cardiomyopathy

    Alan G. Japp;Ankur Gulati;Stuart A. Cook;Martin R. Cowie

  • The Translational Landscape of the Human Heart

    Sebastiaan van Heesch;Franziska Witte;Valentin Schneider-Lunitz;Jana F. Schulz

  • Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

    Angharad M. Roberts;Angharad M. Roberts;James S. Ware;Daniel S. Herman;Daniel S. Herman;Daniel S. Herman;Sebastian Schafer

  • Using high-resolution variant frequencies to empower clinical genome interpretation

    Nicola Whiffin;Nicola Whiffin;Eric Minikel;Eric Minikel;Roddy Walsh;Roddy Walsh;Anne H O’Donnell-Luria;Anne H O’Donnell-Luria

  • Adaptation and validation of the ACMG/AMP variant classification framework for MYH7-associated inherited cardiomyopathies: recommendations by ClinGen’s Inherited Cardiomyopathy Expert Panel

    Melissa A Kelly;Colleen Caleshu;Ana Morales;Jillian Buchan

  • A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy

    Eric Villard;Claire Perret;Françoise Gary;Carole Proust

  • MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism.

    Han Lu;Rachel J. Buchan;Stuart A. Cook;Stuart A. Cook

  • Regulation of Bcl-2 Family Proteins During Development and in Response to Oxidative Stress in Cardiac Myocytes Association With Changes in Mitochondrial Membrane Potential

    Stuart A. Cook;Peter H. Sugden;Angela Clerk

  • Anatomically Constrained Neural Networks (ACNN): Application to Cardiac Image Enhancement and Segmentation

    Ozan Oktay;Enzo Ferrante;Konstantinos Kamnitsas;Mattias Heinrich

Frequent Co-Authors

Paul J.R. Barton
Paul J.R. Barton Imperial College London
Sanjay K. Prasad
Sanjay K. Prasad National Institutes of Health
Norbert Hubner
Norbert Hubner Max Delbrück Center for Molecular Medicine
Daniel Rueckert
Daniel Rueckert Technical University of Munich
Dudley J. Pennell
Dudley J. Pennell National Institutes of Health
Christine E. Seidman
Christine E. Seidman Harvard University
Wenjia Bai
Wenjia Bai Imperial College London
Michal Pravenec
Michal Pravenec Czech Academy of Sciences
Enrico Petretto
Enrico Petretto Duke NUS Graduate Medical School
Jonathan G. Seidman
Jonathan G. Seidman Harvard University

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