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Genetics

D-Index
75
Citations
16817
World Ranking
1910
National Ranking
243

Overview

Paul J.R. Barton is affiliated with Imperial College London in the United Kingdom and has a significant body of research primarily focused on cardiology, genetics, and molecular biology.

Their main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these fields, Paul J.R. Barton has contributed extensively to several subfields such as:

  • Cardiology and Cardiovascular Medicine
  • Molecular Biology
  • Genetics
  • Epidemiology
  • Developmental Neuroscience

Their research topics reflect a focus on cardiovascular and genetic disorders, including:

  • Cardiomyopathy and Myosin Studies
  • Congenital heart defects research
  • Genetic Associations and Epidemiology
  • Cardiovascular Effects of Exercise
  • Genomics and Rare Diseases
  • Viral Infections and Immunology Research
  • Williams Syndrome Research

Paul J.R. Barton has co-authored numerous scientific papers often collaborating with several key researchers such as:

  • Stuart A. Cook
  • James S. Ware
  • Rachel Buchan
  • Pantazis Theotokis
  • Roddy Walsh

Their recent publications include:

  • Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect (2021) in Nature Genetics
  • Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy (2020) in Circulation
  • Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies (2022) in Science
  • Genetic Architecture of Acute Myocarditis and the Overlap With Inherited Cardiomyopathy (2022) in Circulation
  • Phenotypic Expression and Outcomes in Individuals With Rare Genetic Variants of Hypertrophic Cardiomyopathy (2021) in Journal of the American College of Cardiology

Their work has been published frequently in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Circulation
  • Nature Genetics
  • European Heart Journal
  • Journal of the American College of Cardiology

Best Publications

  • Truncations of Titin Causing Dilated Cardiomyopathy

    Daniel S. Herman;Lien Lam;Matthew R.G. Taylor;Libin Wang

  • Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium.

    M Arai;N R Alpert;D H MacLennan;P Barton

  • Developmental regulation of myosin gene expression in mouse cardiac muscle.

    G E Lyons;S Schiaffino;D Sassoon;P Barton

  • The Translational Landscape of the Human Heart

    Sebastiaan van Heesch;Franziska Witte;Valentin Schneider-Lunitz;Jana F. Schulz

  • Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

    Angharad M. Roberts;Angharad M. Roberts;James S. Ware;Daniel S. Herman;Daniel S. Herman;Daniel S. Herman;Sebastian Schafer

  • Using high-resolution variant frequencies to empower clinical genome interpretation

    Nicola Whiffin;Nicola Whiffin;Eric Minikel;Eric Minikel;Roddy Walsh;Roddy Walsh;Anne H O’Donnell-Luria;Anne H O’Donnell-Luria

  • Troponin I gene expression during human cardiac development and in end-stage heart failure.

    S. Sasse;N. J. Brand;P. Kyprianou;G. K. Dhoot

  • Titin-truncating variants affect heart function in disease cohorts and the general population

    Sebastian Schafer;Antonio de Marvao;Eleonora Adami;Lorna R Fiedler

  • Localization of human immunoglobulin kappa light chain variable region genes to the short arm of chromosome 2 by in situ hybridization

    S Malcolm;P Barton;C Murphy;M A Ferguson-Smith

  • Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect

    Rafik Tadros;Rafik Tadros;Catherine Francis;Catherine Francis;Xiao Xu;Alexa M.C. Vermeer

  • Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy.

    Pablo Garcia-Pavia;Yuri Kim;Maria Alejandra Restrepo-Cordoba;Ida G. Lunde;Ida G. Lunde

  • Hyperubiquitination of proteins in dilated cardiomyopathy.

    John Weekes;Karen Morrison;Anthony Mullen;Robin Wait

  • Genetic Etiology for Alcohol-Induced Cardiac Toxicity

    James S. Ware;Almudena Amor-Salamanca;Upasana Tayal;Risha Govind

  • Molecular cloning of human cardiac troponin I using polymerase chain reaction

    William J. Vallins;Nigel J. Brand;Nina Dabhade;Gillian Butler-Browne

  • The myosin alkali light chain proteins and their genes

    P J R Barton;M E Buckingham

  • Direct Intramyocardial But Not Intracoronary Injection of Bone Marrow Cells Induces Ventricular Arrhythmias in a Rat Chronic Ischemic Heart Failure Model

    Satsuki Fukushima;Anabel Varela-Carver;Steven R. Coppen;Kenichi Yamahara

  • RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

    Henrike Maatz;Marvin Jens;Martin Liss;Sebastian Schafer

  • Expression of homeobox genes Msx-1 (Hox-7) and Msx-2 (Hox-8) during cardiac development in the chick

    Penny S. Chan-Thomas;Robert P. Thompson;Benoît Robert;Magdi H. Yacoub

  • A conserved family of genes related to the testis determining gene, SRY

    Paul Denny;Sally Swift;Nigel Brand;Nina Dabhade

  • Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes

    Roddy Walsh;Roddy Walsh;Rachel Buchan;Rachel Buchan;Alicja Wilk;Alicja Wilk;Shibu John;Shibu John

Frequent Co-Authors

Magdi H. Yacoub
Magdi H. Yacoub Imperial College London
Stuart A. Cook
Stuart A. Cook Duke NUS Graduate Medical School
Sanjay K. Prasad
Sanjay K. Prasad National Institutes of Health
Christine E. Seidman
Christine E. Seidman Harvard University
Margaret Buckingham
Margaret Buckingham Institut Pasteur
Norbert Hubner
Norbert Hubner Max Delbrück Center for Molecular Medicine
Konrad J. Karczewski
Konrad J. Karczewski Harvard University
Dudley J. Pennell
Dudley J. Pennell National Institutes of Health
Jonathan G. Seidman
Jonathan G. Seidman Harvard University

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