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Biology and Biochemistry

D-Index
94
Citations
32933
World Ranking
2007
National Ranking
1095

Overview

Jack Lawler is affiliated with Beth Israel Deaconess Medical Center in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these broad areas, Lawler's work focuses on several subfields including Molecular Biology, Cell Biology, Cancer Research, Oncology, and Surgery.

The scientist's research topics cover:

  • Angiogenesis and VEGF in Cancer
  • Cancer, Hypoxia, and Metabolism
  • Glycosylation and Glycoproteins Research
  • Monoclonal and Polyclonal Antibodies Research
  • Proteoglycans and glycosaminoglycans research
  • ATP Synthase and ATPases Research
  • Microtubule and mitosis dynamics

Lawler has contributed to various publication venues with multiple papers appearing in Molecular Therapy and Cancer Research. Other venues include Cancers, BJS Open, and Seminars in Cancer Biology. Frequent collaborators in their research include Jim Petrik, Duncan Petrik, Kathy Matuszewska, Madison Pereira, and Peter M. Sadow.

Recent papers include:

  • Meta-analysis of the impact of postoperative infective complications on oncological outcomes in colorectal cancer surgery, 2020, BJS Open
  • Counter regulation of tumor angiogenesis by vascular endothelial growth factor and thrombospondin-1, 2022, Seminars in Cancer Biology

Additional related research contributions appear through collaborative efforts in publications such as:

  • Normalizing Tumor Vasculature to Reduce Hypoxia, Enhance Perfusion, and Optimize Therapy Uptake, 2021, Cancers

The scope of Lawler's work involves understanding and regulating tumor biology, particularly through mechanisms of angiogenesis and tumor microenvironment interactions. Their studies integrate molecular approaches and clinical perspectives, including outcomes related to oncological surgery.

Best Publications

  • Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis

    Karen S. Christopherson;Erik M. Ullian;Caleb C.A. Stokes;Christine E. Mullowney

  • Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

    Susan E Crawford;Susan E Crawford;Veronica Stellmach;Joanne E Murphy-Ullrich;Solange M.F Ribeiro

  • Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

    Çagla Eroglu;Çagla Eroglu;Nicola J. Allen;Michael W. Susman;Nancy A. O'Rourke

  • The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.

    J Lawler;R O Hynes

  • Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth.

    Jack Lawler

  • CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes.

    Patricia Oquendo;Erika Hundt;Jack Lawler;Brian Seed;Brian Seed

  • Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors.

    Jack Lawler;Robert Weinstein;Richard O. Hynes

  • Isolation and characterization of a high molecular weight glycoprotein from human blood platelets.

    J W Lawler;H S Slayter;J E Coligan

  • Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

    Juan Carlos Rodríguez-Manzaneque;Timothy F. Lane;María Asunción Ortega;Richard O. Hynes

  • Molecular Basis for the Regulation of Angiogenesis by Thrombospondin-1 and -2

    Patrick R. Lawler;Jack Lawler

  • The functions of thrombospondin-1 and-2.

    Jack Lawler

  • Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia.

    Jack Lawler;Mary Sunday;Valérie Thibert;Mark Duquette

  • Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy

    Guido Bocci;Giulio Francia;Shan Man;Jack Lawler

  • The cell biology of thrombospondin-1

    Hui Chen;Mary E. Herndon;Jack Lawler

  • The structural and functional properties of thrombospondin

    J Lawler

  • Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis: Implications for cellular surrogate marker analysis of antiangiogenesis

    Yuval Shaked;Francesco Bertolini;Shan Man;Michael S. Rogers

  • Critical Role of Endogenous Thrombospondin-1 in Preventing Expansion of Healing Myocardial Infarcts

    Nikolaos G. Frangogiannis;Guofeng Ren;Oliver Dewald;Pawel Zymek

  • Inhibition of Angiogenesis by Thrombospondin-1 Is Mediated by 2 Independent Regions Within the Type 1 Repeats

    M. Luisa Iruela-Arispe;Michele Lombardo;Henry C. Krutzsch;Jack Lawler

  • Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia.

    Jacqueline T. Hecht;Laura D. Nelson;Eric Crowder;Yang Wang

  • Gabapentin Receptor alpha 2 delta-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

    Cagla Eroglu;Nicola J. Allen;Michael W. Susman;Nancy A. O'Rourke

Frequent Co-Authors

Jiri Palek
Jiri Palek Tufts University
Jacqueline T. Hecht
Jacqueline T. Hecht The University of Texas Health Science Center at Houston
Deane F. Mosher
Deane F. Mosher University of Wisconsin–Madison
Paul Bornstein
Paul Bornstein University of Washington
David D. Roberts
David D. Roberts National Institutes of Health
Joanne E. Murphy-Ullrich
Joanne E. Murphy-Ullrich University of Alabama at Birmingham
Noel P. Bouck
Noel P. Bouck Northwestern University
Roya Khosravi-Far
Roya Khosravi-Far Beth Israel Deaconess Medical Center

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