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Biology and Biochemistry

D-Index
66
Citations
25895
World Ranking
8457
National Ranking
3805

Overview

Khandan Keyomarsi is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research spans multiple disciplines, primarily within Medicine and Biochemistry, Genetics, and Molecular Biology, with a significant focus on Oncology and Pulmonary and Respiratory Medicine.

The main topics of Keyomarsi's work include:

  • Advanced Breast Cancer Therapies
  • Cancer-related Molecular Pathways
  • HER2/EGFR in Cancer Research
  • Microtubule and mitosis dynamics
  • Cancer Genomics and Diagnostics
  • DNA Repair Mechanisms
  • Cancer Cells and Metastasis

Their frequent publication venues demonstrate a concentration in cancer-related research, including:

  • Cancer Research
  • Journal of Clinical Oncology
  • Cancers
  • Pharmacological Reviews
  • Clinical Cancer Research

Among recent papers authored or co-authored by Keyomarsi are:

  • "Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance" (2024) Nature Communications
  • "Multicenter Phase II Trial of the WEE1 Inhibitor Adavosertib in Refractory Solid Tumors Harboring CCNE1 Amplification" (2022) Journal of Clinical Oncology
  • "PARP inhibitors as single agents and in combination therapy: the most promising treatment strategies in clinical trials for BRCA-mutant ovarian and triple-negative breast cancers" (2022) Expert Opinion on Investigational Drugs
  • "Evaluation of Alisertib Alone or Combined With Fulvestrant in Patients With Endocrine-Resistant Advanced Breast Cancer" (2023) JAMA Oncology
  • "Abemaciclib Is Effective in Palbociclib-Resistant Hormone Receptor-Positive Metastatic Breast Cancers" (2023) Cancer Research

Keyomarsi has collaborated frequently with a number of researchers, including:

  • Kelly K. Hunt
  • Tuyen Bui
  • Nicole M. Kettner
  • Debu Tripathy
  • Akshara Singareeka Raghavendra

Their scholarly output reflects an emphasis on cancer biology, molecular mechanisms underlying cancer progression, and therapeutic approaches targeting resistant and advanced breast cancers. Key areas of study integrate cell biology and molecular biology techniques to examine cancer genomics, DNA repair, and cellular pathways involved in tumor growth and resistance mechanisms.

Best Publications

  • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

    J. Wade Harper;Guy R. Adami;Nan Wei;Khandan Keyomarsi

  • Inhibition of cyclin-dependent kinases by p21.

    J W Harper;S J Elledge;K Keyomarsi;B Dynlacht

  • Role of cell cycle in mediating sensitivity to radiotherapy.

    Timothy M. Pawlik;Khandan Keyomarsi

  • Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCFFbw7 Ubiquitin Ligase

    Deanna M. Koepp;Laura K. Schaefer;Xin Ye;Khandan Keyomarsi

  • Cyclin E and Survival in Patients with Breast Cancer

    Khandan Keyomarsi;Susan L. Tucker;Thomas A. Buchholz;Matthew Callister

  • Redundant cyclin overexpression and gene amplification in breast cancer cells

    Khandan Keyomarsi;Arthur B. Pardee

  • Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin.

    Khandan Keyomarsi;Larue Sandoval;Vimla Band;Arthur B. Pardee

  • Cyclin E, a Potential Prognostic Marker for Breast Cancer

    Khandan Keyomarsi;Nuala O'Leary;Gyongyi Molnar;Emma Lees

  • Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells.

    Peng Liang;Lidia Averboukh;Khandan Keyomarsi;Ruth Sager

  • Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.

    Sarah S. Bacus;Andrei V. Gudkov;Michael Lowe;Ljuba Lyass

  • Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase

    Sharmila Rao;Donald C. Porter;Xiaomei Chen;Thaddeus Herliczek

  • Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines.

    S. W. Lee;C. Tomasetto;D. Paul;Khandan Keyomarsi

  • Deregulation of cyclin E in breast cancer

    K. Keyomarsi;D. Conte;W. Toyofuku;M. P. Fox

  • Atypical PKCι contributes to poor prognosis through loss of apical-basal polarity and Cyclin E overexpression in ovarian cancer

    Astrid M. Eder;Xiaomei Sui;Daniel G. Rosen;Laura K. Nolden

  • Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G0/G1 to S phase transition in normal and tumor cells

    Keith D. Robertson;Khandan Keyomarsi;Felicidad A. Gonzales;Mihaela Velicescu

  • An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology.

    Alfred I. Geller;Khandan Keyomarsi;John Bryan;John Bryan;Arthur B. Pardee

  • Expression of cytochromes P450 in human breast tissue and tumors.

    Zeqi Huang;Michael J. Fasco;Michael J. Fasco;Helen L. Figge;Khandan Keyomarsi

  • Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight forms.

    Donald C. Porter;Ning Zhang;Christopher Danes;Mollianne J. McGahren

  • CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

    Smruthi Vijayaraghavan;Cansu Karakas;Iman Doostan;Xian Chen

  • Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.

    Khandan K. Keyomarsi;Richard G. Moran

Frequent Co-Authors

Kelly K. Hunt
Kelly K. Hunt The University of Texas MD Anderson Cancer Center
Aysegul A. Sahin
Aysegul A. Sahin The University of Texas MD Anderson Cancer Center
Joseph A. Caruso
Joseph A. Caruso Wayne State University
Arthur B. Pardee
Arthur B. Pardee Harvard University
Susan L. Tucker
Susan L. Tucker The University of Texas MD Anderson Cancer Center
Gordon B. Mills
Gordon B. Mills Oregon Health & Science University
Laurent Meijer
Laurent Meijer Perha Pharmaceuticals
Ian O. Ellis
Ian O. Ellis University of Nottingham
Jing Wang
Jing Wang The University of Texas MD Anderson Cancer Center
Michelle Craig Barton
Michelle Craig Barton The University of Texas MD Anderson Cancer Center

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