His primary scientific interests are in Cell biology, Cyclin-dependent kinase, Cyclin A, Cyclin D and Cyclin A2. His biological study spans a wide range of topics, including Cell cycle and Cyclin. His study in Cyclin is interdisciplinary in nature, drawing from both Kinase and Cyclin-dependent kinase 2.
His Cyclin-dependent kinase research focuses on Restriction point in particular. His Cyclin A research is multidisciplinary, incorporating perspectives in Cyclin-dependent kinase 1, Cyclin-dependent kinase complex, Molecular biology and Cyclin B. His Cyclin D study incorporates themes from Cyclin E, Cyclin binding and Cyclin D3.
James M. Roberts spends much of his time researching Cell biology, Cyclin-dependent kinase, Cyclin E, Cell cycle and Cyclin. The Cell biology study combines topics in areas such as Molecular biology, Cell division, Cyclin A and Cyclin-dependent kinase 2. His Cyclin A study combines topics from a wide range of disciplines, such as Cyclin-dependent kinase 1, Cyclin A2, Polo-like kinase and Cyclin D.
As part of the same scientific family, James M. Roberts usually focuses on Cyclin A2, concentrating on Cyclin-dependent kinase complex and intersecting with Cyclin-dependent kinase 3. His study looks at the intersection of Cyclin-dependent kinase and topics like Cytoplasm with Tyrosine kinase. James M. Roberts has included themes like Progenitor cell, Cancer research, Cell growth and Cellular differentiation in his Cell cycle study.
James M. Roberts mostly deals with Cell biology, Cell cycle, Cyclin-dependent kinase, Cyclin A and Cancer research. Specifically, his work in Cell biology is concerned with the study of Kinase. His work on Restriction point as part of general Cell cycle research is frequently linked to Cell fate determination, thereby connecting diverse disciplines of science.
His biological study spans a wide range of topics, including Cytoplasm, Carcinogenesis, Tyrosine kinase, Kinase activity and Leukemia. His Cyclin A study combines topics in areas such as Cyclin-dependent kinase 1, Cyclin A2, Tissue homeostasis, Polo-like kinase and Cyclin D. Cyclin E is closely connected to Cyclin B in his research, which is encompassed under the umbrella topic of Cyclin A2.
His primary areas of investigation include Cell biology, Cell cycle, Cyclin A, Cyclin-dependent kinase and Cyclin D. His Cell biology research is multidisciplinary, incorporating perspectives in Cellular differentiation, Cyclin-dependent kinase 1, Histone deacetylase, Cyclin D1 and Telomerase reverse transcriptase. His Cyclin-dependent kinase 1 research includes elements of Restriction point, Tissue homeostasis and Polo-like kinase.
His research on Cyclin D1 focuses in particular on Cyclin E. His work deals with themes such as Molecular biology, Cyclin A2 and Cyclin B, which intersect with Cyclin D. His Cyclin A2 study frequently draws parallels with other fields, such as Kinase.
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CDK inhibitors: positive and negative regulators of G1-phase progression
Charles J. Sherr;James M. Roberts.
Genes & Development (1999)
Inhibitors of mammalian G1 cyclin-dependent kinases.
C J Sherr;J M Roberts.
Genes & Development (1995)
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
Kornelia Polyak;Mong Hong Lee;Hediye Erdjument-Bromage;Andrew Koff.
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
Kornelia Polyak;Jun-ya Kato;Mark J. Solomon;Charles J. Sherr.
Genes & Development (1994)
A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27Kip1-Deficient Mice
Matthew L. Fero;Michael Rivkin;Michael Tasch;Peggy Porter.
Human cyclin E, a nuclear protein essential for the G1-to-S phase transition.
Motoaki Ohtsubo;Anne M. Theodoras;Jill Schumacher;James M. Roberts.
Molecular and Cellular Biology (1995)
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle
Koff A;Giordano A;Desai D;Yamashita K.
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin.
Jamison Nourse;Eduardo Firpo;W. Michael Flanagan;Steve Coats.
Cyclin E-CDK2 is a regulator of p27Kip1.
Robert J. Sheaff;Mark Groudine;Matthew Gordon;James M. Roberts.
Genes & Development (1997)
Living with or without cyclins and cyclin-dependent kinases
Charles J. Sherr;James M. Roberts.
Genes & Development (2004)
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