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D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
23709
World Ranking
11107
National Ranking
4807

Overview

Andrew Koff is affiliated with the Memorial Sloan Kettering Cancer Center in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a notable emphasis on oncology and molecular mechanisms underlying cancer progression and treatment.

The scientist's research contributions frequently cover the following topics:

  • Advanced Breast Cancer Therapies
  • Cancer-related Molecular Pathways
  • Cancer-related cognitive impairment studies
  • Protein Degradation and Inhibitors
  • Cancer Mechanisms and Therapy
  • Sarcoma Diagnosis and Treatment
  • Cancer Immunotherapy and Biomarkers

Koff has published extensively in several key scientific venues, including:

  • Cancer Research
  • Pharmacological Reviews
  • Clinical Cancer Research
  • Cancer Cell
  • bioRxiv (Cold Spring Harbor Laboratory)

The scientist's recent papers illustrate a focus on cell cycle regulation, cancer therapy resistance, and immunotherapy approaches. Selected publications include:

  • INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors, 2021, Cancer Discovery
  • Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma, 2022, Nature Communications
  • Cell cycle dysregulation in cancer, 2024, Pharmacological Reviews
  • Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma, 2023, Clinical Cancer Research
  • Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversion, 2024, Cancer Cell

Frequent co-authors in their publications include Sarat Chandarlapaty, Rei Kudo, Pedram Razavi, Anton Safonov, and Hong Shao, indicating collaborative work in cancer biology and therapy-focused research.

The scientist's work incorporates subfields such as Pulmonary and Respiratory Medicine, Oncology, Molecular Biology, Cancer Research, and Pathology and Forensic Medicine, reflecting a multidisciplinary approach to cancer research and treatment development.

Best Publications

  • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

    Kornelia Polyak;Mong Hong Lee;Hediye Erdjument-Bromage;Andrew Koff

  • p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

    Kornelia Polyak;Jun-ya Kato;Mark J. Solomon;Charles J. Sherr

  • Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27Kip1

    Hiroaki Kiyokawa;Rhonda D Kineman;Katia O Manova-Todorova;Vera C Soares

  • Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

    Koff A;Giordano A;Desai D;Yamashita K

  • Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.

    Andrew Koff;Fred Cross;Alfred L Fisher;Jill Schumacher

  • Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta

    Andrew Koff;Masahiko Ohtsuki;Kornelia Polyak;James M. Roberts

  • Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

    Antonio Di Cristofano;Marika De Acetis;Andrew Koff;Carlos Cordon-Cardo

  • p53 Regulates Hematopoietic Stem Cell Quiescence

    Yan Liu;Shannon E. Elf;Yasuhiko Miyata;Goro Sashida

  • Cell-cycle inhibitors: three families united by a common cause.

    Anxo Vidal;Andrew Koff

  • Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity.

    Tateki Tsutsui;Bahar Hesabi;David S. Moons;Pier Paolo Pandolfi

  • p27Kip1 induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells

    Siva Kumar Kolluri;Carsten Weiss;Andrew Koff;Martin Göttlicher

  • Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.

    E. S. Hoffman;L. Passoni;T. Crompton;T. M. J. Leu

  • The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

    C Missero;F Di Cunto;H Kiyokawa;A Koff

  • Prostate cancer cell cycle regulators: response to androgen withdrawal and development of androgen independence.

    David B. Agus;Carlos Cordon-Cardo;William Fox;Marija Drobnjak

  • Distinct Altered Patterns of p27KIP1 Gene Expression in Benign Prostatic Hyperplasia and Prostatic Carcinoma

    Carlos Cordon-Cardo;Andrew Koff;Marija Drobnjak;Paola Capodieci

  • CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought.

    Mary E. Klein;Marta Kovatcheva;Lara E. Davis;William D. Tap

  • Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody.

    Xipu Wu;Mark Rubin;Zhen Fan;Tony DeBlasio

  • Formation of p27-CDK complexes during the human mitotic cell cycle

    Timothy J. Soos;Hiroaki Kiyokawa;Jie Shi Yan;Mark Stephen Rubin

  • Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1.

    Patrizia Casaccia-Bonnefil;Ravi Tikoo;Hiroaki Kiyokawa;Victor Friedrich

  • Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle: Science 257, 1689–1694

    A. Koff;V. Dulic;E. Lees;S.I. Reed

Frequent Co-Authors

Samuel Singer
Samuel Singer Memorial Sloan Kettering Cancer Center
Hiroaki Kiyokawa
Hiroaki Kiyokawa Northwestern University
Carlos Cordon-Cardo
Carlos Cordon-Cardo Icahn School of Medicine at Mount Sinai
Stephen D. Nimer
Stephen D. Nimer University of Miami
Howard I. Scher
Howard I. Scher Memorial Sloan Kettering Cancer Center
Moses V. Chao
Moses V. Chao New York University
Katia Manova
Katia Manova Memorial Sloan Kettering Cancer Center
Eric C. Holland
Eric C. Holland Fred Hutchinson Cancer Research Center
Cristina R. Antonescu
Cristina R. Antonescu Memorial Sloan Kettering Cancer Center
Pier Paolo Pandolfi
Pier Paolo Pandolfi Beth Israel Deaconess Medical Center

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