His scientific interests lie mostly in Cyclin E, Cell biology, Ubiquitin ligase, Cyclin-dependent kinase and Cyclin A2. His Molecular biology research extends to Cell biology, which is thematically connected. His study in the fields of F-box protein under the domain of Ubiquitin ligase overlaps with other disciplines such as Amyloid precursor protein secretase.
His F-box protein research incorporates themes from Carcinogenesis and Cell growth. Bruce E. Clurman has researched Cyclin-dependent kinase in several fields, including Caspase 2, Kinase and Cyclin-dependent kinase 2. His Cyclin A2 research includes elements of Cyclin B, Cyclin A and Cyclin D.
His primary scientific interests are in Cell biology, Cancer research, Cyclin E, Ubiquitin ligase and Cyclin-dependent kinase. Bruce E. Clurman interconnects Molecular biology, Ubiquitin, F-box protein and Biochemistry in the investigation of issues within Cell biology. His Cancer research study incorporates themes from Carcinogenesis, Cell cycle, Gene, Stem cell and Wee1.
The various areas that Bruce E. Clurman examines in his Cyclin E study include Genome instability, Cyclin A, Cell growth and Kinase activity. His Cyclin A research is multidisciplinary, incorporating perspectives in Cyclin A2 and Cyclin D. His study focuses on the intersection of Ubiquitin ligase and fields such as Protein degradation with connections in the field of Degron.
Bruce E. Clurman spends much of his time researching Cancer research, Wee1, Cell cycle, Ubiquitin ligase and DNA damage. His Cancer research study integrates concerns from other disciplines, such as Insertional mutagenesis, Transposase, Carcinogenesis, Gene and Cyclin. His work deals with themes such as Cancer cell and T cell, which intersect with Cell cycle.
His Ubiquitin ligase research includes themes of Small hairpin RNA, Colorectal cancer, Metabolic reprogramming and Cell biology. His biological study spans a wide range of topics, including Embryonic stem cell, Germ line development, Cell growth, Binding site and Consensus site. Bruce E. Clurman has included themes like Cyclin-dependent kinase 1, Cyclin E and Programmed cell death in his Cyclin-dependent kinase study.
Bruce E. Clurman mainly focuses on Cancer research, Carcinogenesis, Ubiquitin, DNA and DNA repair. He interconnects Insertional mutagenesis, Transposase, Sleeping Beauty transposon system, Mitochondrion and Cyclin in the investigation of issues within Cancer research. Bruce E. Clurman has researched Carcinogenesis in several fields, including HEK 293 cells, Viral replication and Antigen.
His research on Ubiquitin focuses in particular on Ubiquitin ligase. His DNA research integrates issues from Drosha, Cell biology, Binding site and Consensus site. His study in DNA repair is interdisciplinary in nature, drawing from both Molecular biology, microRNA and DNA damage.
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Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Bin Zhang;Chris Gaiteri;Liviu Gabriel Bodea;Zhi Wang.
Cyclin E-CDK2 is a regulator of p27Kip1.
Robert J. Sheaff;Mark Groudine;Matthew Gordon;James M. Roberts.
Genes & Development (1997)
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.
Markus Welcker;Bruce E. Clurman;Bruce E. Clurman.
Nature Reviews Cancer (2008)
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
Markus Welcker;Amir Orian;Jianping Jin;Jonathan A. Grim;Jonathan A. Grim.
Proceedings of the National Academy of Sciences of the United States of America (2004)
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors
Jennifer O'Neil;Jonathan Grim;Peter Strack;Sudhir Rao.
Journal of Experimental Medicine (2007)
Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.
Bruce E. Clurman;Robert J. Sheaff;Kenneth Thress;Mark Groudine.
Genes & Development (1996)
Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade
Bodo Levkau;Hidenori Koyama;Elaine W. Raines;Bruce E. Clurman.
Molecular Cell (1998)
Cyclin E in normal and neoplastic cell cycles
Harry C Hwang;Bruce E Clurman;Bruce E Clurman.
Proteasomal Turnover of p21Cip1 Does Not Require p21Cip1 Ubiquitination
Robert J Sheaff;Robert J Sheaff;Jeffrey D Singer;Jherek Swanger;Matthew Smitherman.
Molecular Cell (2000)
Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells
Jeffrey D. Singer;Mark Gurian-West;Bruce Clurman;James M. Roberts.
Genes & Development (1999)
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