World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
16950
World Ranking
17418
National Ranking
7156

Overview

Bruce E. Clurman is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with significant focus on oncology and related subfields.

The main fields of study represented in their work include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

More specific subfields they have contributed to are:

  • Molecular Biology
  • Oncology
  • Genetics
  • Biotechnology
  • Cell Biology

Key topics covered in their publications encompass:

  • Ubiquitin and proteasome pathways
  • Peptidase Inhibition and Analysis
  • Protein Degradation and Inhibitors
  • Cancer-related Molecular Pathways
  • Genetics and Neurodevelopmental Disorders
  • Enzyme Production and Characterization
  • Microtubule and mitosis dynamics

Recent papers authored or co-authored by Clurman show a focus on molecular mechanisms related to protein degradation and cancer biology. Notable publications include:

  • Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor, 2022, Science Advances
  • A novel landscape of nuclear human CDK2 substrates revealed by in situ phosphorylation, 2020, Science Advances
  • Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12, 2021, Nature Communications
  • FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition, 2020, Proceedings of the National Academy of Sciences
  • Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations, 2021, bioRxiv (Cold Spring Harbor Laboratory)

Frequent publication venues reflect the interdisciplinary nature of their work and include:

  • Science Advances
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical Cancer Research

Collaboration plays a role in their research, with multiple co-authors appearing regularly in their publications. These frequent co-authors include:

  • Jherek Swanger
  • Ahmed Diab
  • Omar M. Khan
  • Jorge Almagro
  • Jessica K. Nelson

Best Publications

  • Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

    Bin Zhang;Chris Gaiteri;Liviu Gabriel Bodea;Zhi Wang

  • Cyclin E-CDK2 is a regulator of p27Kip1.

    Robert J. Sheaff;Mark Groudine;Matthew Gordon;James M. Roberts

  • FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.

    Markus Welcker;Bruce E. Clurman;Bruce E. Clurman

  • The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

    Markus Welcker;Amir Orian;Jianping Jin;Jonathan A. Grim;Jonathan A. Grim

  • FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

    Jennifer O'Neil;Jonathan Grim;Peter Strack;Sudhir Rao

  • Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.

    Bruce E. Clurman;Robert J. Sheaff;Kenneth Thress;Mark Groudine

  • Cyclin E in normal and neoplastic cell cycles

    Harry C Hwang;Bruce E Clurman;Bruce E Clurman

  • Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade

    Bodo Levkau;Hidenori Koyama;Elaine W. Raines;Bruce E. Clurman

  • Proteasomal Turnover of p21Cip1 Does Not Require p21Cip1 Ubiquitination

    Robert J Sheaff;Robert J Sheaff;Jeffrey D Singer;Jherek Swanger;Matthew Smitherman

  • Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

    Jeffrey D. Singer;Mark Gurian-West;Bruce Clurman;James M. Roberts

  • Multisite Phosphorylation by Cdk2 and GSK3 Controls Cyclin E Degradation.

    Markus Welcker;Jeffrey Singer;Keith R. Loeb;Jonathan Grim

  • A Nucleolar Isoform of the Fbw7 Ubiquitin Ligase Regulates c-Myc and Cell Size

    Markus Welcker;Amir Orian;Jonathan A. Grim;Jonathan A. Grim;Robert N. Eisenman

  • Ubiquitin-Independent Degradation of Cell-Cycle Inhibitors by the REGγ Proteasome

    Xueyan Chen;Lance F. Barton;Yong Chi;Bruce E. Clurman

  • Tumor Suppression by the Fbw7 Ubiquitin Ligase: Mechanisms and Opportunities

    Ryan J. Davis;Markus Welcker;Bruce E. Clurman

  • Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins

    Nathan W. Pierce;J. Eugene Lee;Xing Liu;Michael J. Sweredoski

  • Notch Activation Induces Endothelial Cell Cycle Arrest and Participates in Contact Inhibition: Role of p21Cip1 Repression

    Michela Noseda;Linda Chang;Graeme McLean;Jonathan E. Grim

  • Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

    David M. Thomas;Sandra A. Johnson;Natalie A. Sims;Melanie K. Trivett

  • Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype

    Arnaud Besson;Harry C. Hwang;Samantha Cicero;Stacy L. Donovan

  • Werner syndrome protein limits MYC-induced cellular senescence.

    Carla Grandori;Kou Juey Wu;Paula Fernandez;Celine Ngouenet

  • Kinase-independent function of cyclin E.

    Yan Geng;Young Mi Lee;Markus Welcker;Jherek Swanger

Frequent Co-Authors

James M. Roberts
James M. Roberts Lumen Bioscience
Mark Groudine
Mark Groudine Fred Hutchinson Cancer Research Center
Denise A. Galloway
Denise A. Galloway Fred Hutchinson Cancer Research Center
James M. Olson
James M. Olson Fred Hutchinson Cancer Research Center
Robert N. Eisenman
Robert N. Eisenman Fred Hutchinson Cancer Research Center
Steven M. Pollard
Steven M. Pollard University of Edinburgh
Jeongwu Lee
Jeongwu Lee Case Western Reserve University
J. Wade Harper
J. Wade Harper Harvard Medical School
Frederick R. Appelbaum
Frederick R. Appelbaum Fred Hutchinson Cancer Research Center

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