World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
93
Citations
29868
World Ranking
2120
National Ranking
1149

Research.com Recognitions

  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Isaac N. Pessah is affiliated with the University of California, Davis, in the United States. Their research spans multiple interconnected fields with a primary focus on biochemistry, genetics, and molecular biology, as well as neuroscience.

The scientist's main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Within these fields, their work dives into several subfields such as molecular biology, genetics, cellular and molecular neuroscience, physiology, and cognitive neuroscience.

Key topics addressed in their research cover:

  • Ion channel regulation and function
  • Neuroscience and neuropharmacology research
  • Autism spectrum disorder research
  • Genetics and neurodevelopmental disorders
  • Genomic variations and chromosomal abnormalities
  • Erythrocyte function and pathophysiology
  • Cardiac electrophysiology and arrhythmias

The scientist has published in several venues with repeated contributions to some:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Toxicological Sciences
  • Frontiers in Neuroscience
  • Frontiers in Molecular Biosciences
  • Nature Genetics

Frequent collaborators include Pamela J. Lein, Wei Feng, Shane Antrobus, Irva Hertz-Picciotto, and Jack Fu.

Recent papers authored or co-authored by Isaac N. Pessah highlight various aspects of genetics, neurodevelopment, and neuroscience:

  • Rare coding variation provides insight into the genetic architecture and phenotypic context of autism (2022, Nature Genetics)
  • Rare coding variation illuminates the allelic architecture, risk genes, cellular expression patterns, and phenotypic context of autism (2021, bioRxiv (Cold Spring Harbor Laboratory))
  • Developmental Exposure to a Human-Relevant Polychlorinated Biphenyl Mixture Causes Behavioral Phenotypes That Vary by Sex and Genotype in Juvenile Mice Expressing Human Mutations That Modulate Neuronal Calcium (2021, Frontiers in Neuroscience)
  • The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell (2024, Nature Communications)
  • Sex and Genotype Modulate the Dendritic Effects of Developmental Exposure to a Human-Relevant Polychlorinated Biphenyls Mixture in the Juvenile Mouse (2021, Frontiers in Neuroscience)

Isaac N. Pessah was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2018.

Best Publications

  • Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

    F. Kyle Satterstrom;F. Kyle Satterstrom;Jack A. Kosmicki;Jiebiao Wang;Michael S. Breen

  • Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome.

    Paul Ashwood;Paula Krakowiak;Irva Hertz-Picciotto;Robin L Hansen

  • Functional interaction between InsP3 receptors and store-operated Htrp3 channels.

    Kirill Kiselyov;Xin Xu;Galina Mozhayeva;Tuan Kuo

  • Xestospongins: Potent Membrane Permeable Blockers of the Inositol 1,4,5-Trisphosphate Receptor

    Juliette Gafni;Julia A Munsch;Tien H Lam;Michelle C Catlin

  • Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

    F. Kyle Satterstrom;Jack A. Kosmicki;Jiebiao Wang;Michael S Breen;Michael S Breen

  • The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism.

    Irva Hertz-Picciotto;Lisa A. Croen;Robin L Hansen;Carrie R. Jones

  • Mitochondrial Dysfunction in Autism

    Cecilia R Giulivi;Yi Fan Zhang;Alicja Omanska-Klusek;Catherine Ross-Inta

  • Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor.

    Junichi Nakai;Junichi Nakai;Robert T. Dirksen;Hanh T. Nguyen;Isaac N. Pessah

  • In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens.

    Ki Chang Ahn;Bin Zhao;Jiangang Chen;Gennady Cherednichenko

  • Ca2+-activated ryanodine binding: mechanisms of sensitivity and intensity modulation by Mg2+, caffeine, and adenine nucleotides.

    Isaac N Pessah;R. A. Stambuk;J. E. Casida

  • The calcium-ryanodine receptor complex of skeletal and cardiac muscle.

    Isaac N. Pessah;Andrew L. Waterhouse;John E. Casida

  • Autism: maternally derived antibodies specific for fetal brain proteins.

    Daniel Braunschweig;Paul Ashwood;Paula Krakowiak;Irva Hertz-Picciotto

  • Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders.

    Paul Ashwood;Paula Krakowiak;Irva Hertz-Picciotto;Robin L Hansen

  • Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase

    Christoph F.A. Vogel;Samuel R. Goth;Bin Dong;Isaac N. Pessah;Isaac N. Pessah

  • Autism-specific maternal autoantibodies recognize critical proteins in developing brain

    D Braunschweig;P Krakowiak;P Duncanson;R Boyce

  • Altered T cell responses in children with autism.

    Paul Ashwood;Paula Krakowiak;Irva Hertz-Picciotto;Robin L Hansen

  • DECREASED TRANSFORMING GROWTH FACTOR BETA1 IN AUTISM: A POTENTIAL LINK BETWEEN IMMUNE DYSREGULATION AND IMPAIRMENT IN CLINICAL BEHAVIORAL OUTCOMES

    Paul Ashwood;Amanda Enstrom;Paula Krakowiak;Irva Hertz-Picciotto

  • Altered gene expression and function of peripheral blood natural killer cells in children with autism.

    Amanda M. Enstrom;Lisa Lit;Charity E. Onore;Jeffrey Gregg

  • Calcium-ryanodine receptor complex. Solubilization and partial characterization from skeletal muscle junctional sarcoplasmic reticulum vesicles.

    Isaac N Pessah;A. O. Francini;D. J. Scales;A. L. Waterhouse

  • Symposium overview : Toxicity of non-coplanar PCBs

    Lawrence J. Fischer;Richard F. Seegal;Patricia E. Ganey;Isaac N. Pessah

Frequent Co-Authors

Paul D. Allen
Paul D. Allen St James's University Hospital
Irva Hertz-Picciotto
Irva Hertz-Picciotto University of California, Davis
Pamela J. Lein
Pamela J. Lein University of California, Davis
Robin L Hansen
Robin L Hansen University of California, Davis
Tadeusz F. Molinski
Tadeusz F. Molinski University of California, San Diego
Paul J. Hagerman
Paul J. Hagerman University of California, Davis
Judith A Van de Water
Judith A Van de Water University of California, Davis
Robert F. Berman
Robert F. Berman University of California, Davis
Flora Tassone
Flora Tassone University of California, Davis
Kurt G. Beam
Kurt G. Beam University of Colorado Denver

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