World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
68
Citations
16878
World Ranking
2750
National Ranking
1285

Research.com Recognitions

  • 1975 - Fellow of John Simon Guggenheim Memorial Foundation
  • 1951 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Richard E. Frye is affiliated with the Barrow Neurological Institute in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine, contributing substantially to each with a focus on Cognitive Neuroscience, Genetics, Psychiatry and Mental Health, Molecular Biology, and Clinical Psychology.

The scientist's work covers a broad range of topics related to neurodevelopmental and genetic disorders. Key areas of research include Autism Spectrum Disorder, Genetics and Neurodevelopmental Disorders, Child Nutrition and Feeding Issues, Family and Disability Support, Attention Deficit Hyperactivity Disorder, Genomics and Rare Diseases, and RNA modifications related to cancer.

Richard E. Frye has published extensively, with notable papers including:

  • Mitochondrial Dysfunction in Autism Spectrum Disorder: Unique Abnormalities and Targeted Treatments, 2020, Seminars in Pediatric Neurology
  • The lifetime social cost of autism: 1990-2029, 2020, Research in Autism Spectrum Disorders
  • Early Detection and Diagnosis of Autism Spectrum Disorder: Why Is It So Difficult?, 2020, Seminars in Pediatric Neurology
  • Editorial: Comorbidity and Autism Spectrum Disorder, 2020, Frontiers in Psychiatry
  • Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development, 2023, Nature Genetics

The frequent co-authors in their publications include Daniel A. Rossignol, Shannon Rose, Patrick J. McCarty, Indrapal N. Singh, and Adrienne C. Scheck. Collaboration with these researchers indicates ongoing multi-disciplinary work across molecular biology, clinical studies, and genetics.

Richard E. Frye's research has appeared most often in journals such as the Journal of Personalized Medicine, Preprints.org, Seminars in Pediatric Neurology, International Journal of Molecular Sciences, and Genes. The consistent presence in these publication venues reflects contributions to both clinical neurology and personalized medicine.

The scientist's recognition includes being named a Fellow of the John Simon Guggenheim Memorial Foundation in both 1951 and 1975. These honors underscore a longstanding engagement with pioneering research and scientific contribution over multiple decades.

Best Publications

  • Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

    D A Rossignol;R E Frye

  • A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures.

    D A Rossignol;R E Frye

  • Melatonin in autism spectrum disorders: a systematic review and meta-analysis.

    Daniel A Rossignol;Richard E Frye

  • Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain

    S S Rose;S Melnyk;O Pavliv;S Bai

  • Environmental toxicants and autism spectrum disorders: a systematic review

    D A Rossignol;S J Genuis;R E Frye

  • Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review

    Deepmala;Deepmala;John Slattery;Nihit Kumar;Leanna Delhey

  • High Rate of Recurrent De Novo Mutations in Developmental and Epileptic Encephalopathies

    Fadi F. Hamdan;Candace T. Myers;Patrick Cossette;Philippe Lemay

  • Dose-Related Effects of Cigarette Smoking on Olfactory Function

    Richard E. Frye;Brian S. Schwartz;Richard L. Doty

  • Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism.

    Daniel A. Rossignol;Richard E. Frye

  • Internal consistency reliability of the fractionated and whole University of Pennsylvania Smell Identification Test.

    Richard L. Doty;Richard E. Frye;Udayan Agrawal

  • Cerebral folate receptor autoantibodies in autism spectrum disorder

    R E Frye;J M Sequeira;E V Quadros;S J James

  • Patient care standards for primary mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society

    Sumit Parikh;Amy Goldstein;Amel Karaa;Mary Kay Koenig

  • Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder

    R E Frye;S Melnyk;D F MacFabe

  • Olfactory sensitivity, nasal resistance, and autonomic function in patients with multiple chemical sensitivities.

    Richard L. Doty;Daniel A. Deems;Richard E. Frye;Robert Pelberg

  • Touch, Sound and Vision in Human Superior Temporal Sulcus

    Michael S. Beauchamp;Nafi E. Yasar;Nafi E. Yasar;Richard E. Frye;Tony Ro

  • Mitochondrial Dysfunction Can Connect the Diverse Medical Symptoms Associated With Autism Spectrum Disorders

    Richard E Frye;Daniel A Rossignol

  • Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of Distinction for Diagnosis and Treatment.

    Dmitriy M. Niyazov;Stephan G. Kahler;Richard E. Frye

  • Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder.

    Shannon Rose;Dmitriy M. Niyazov;Daniel A. Rossignol;Michael Goldenthal

  • Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial

    R E Frye;R E Frye;J Slattery;L Delhey;B Furgerson

  • Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism.

    Shannon Rose;Sirish C. Bennuri;Jakeira E. Davis;Rebecca Wynne

  • Developmental Regression and Mitochondrial Dysfunction in a Child With Autism

    Jon S. Poling;Richard E. Frye;John Shoffner;Andrew W. Zimmerman

  • Oxidative Stress Induces Mitochondrial Dysfunction in a Subset of Autism Lymphoblastoid Cell Lines in a Well-Matched Case Control Cohort

    Shannon Rose;Richard E. Frye;John Slattery;Rebecca Wynne

  • Transcranial Magnetic Stimulation in Child Neurology: Current and Future Directions

    Richard E. Frye;Alexander Rotenberg;Molliann Ousley;Alvaro Pascual-Leone

  • Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome.

    Richard E. Frye;Shannon Rose;John Slattery;Derrick F. MacFabe

  • Redox metabolism abnormalities in autistic children associated with mitochondrial disease

    R E Frye;R DeLaTorre;H Taylor;J Slattery;J Slattery

Frequent Co-Authors

Richard L. Doty
Richard L. Doty University of Pennsylvania
Andrew W. Zimmerman
Andrew W. Zimmerman University of Massachusetts Chan Medical School
Paul R. Swank
Paul R. Swank The University of Texas Health Science Center at Houston
Manuel F. Casanova
Manuel F. Casanova University of South Carolina
Susan H. Landry
Susan H. Landry The University of Texas Health Science Center at Houston
George Zouridakis
George Zouridakis University of Houston
Ingrid E. Scheffer
Ingrid E. Scheffer University of Melbourne
Michael S. Beauchamp
Michael S. Beauchamp University of Pennsylvania
Patrick F. Chinnery
Patrick F. Chinnery University of Cambridge
John Christodoulou
John Christodoulou University of Melbourne

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