World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
12524
World Ranking
16020
National Ranking
6649

Overview

Stepan Melnyk is affiliated with the University of Arkansas for Medical Sciences in the United States. Their research spans multiple disciplines, including biochemistry, genetics, molecular biology, medicine, and engineering. Within these broad fields, they have contributed notably to molecular biology, biomedical engineering, mechanical engineering, physiology, and organic chemistry.

Their publication record shows a focus on several scientific topics. These include:

  • Biodiesel Production and Applications
  • Enzyme Catalysis and Immobilization
  • Epigenetics and DNA Methylation
  • Child Nutrition and Feeding Issues
  • Diet and Metabolism Studies
  • Adipose Tissue and Metabolism
  • Process Optimization and Integration

Stepan Melnyk's recent scholarly articles feature diverse themes in biomedical and physiological research. Notable recent papers are:

  • Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder, 2021, Molecular Autism
  • Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology, 2020, Molecular Psychiatry
  • Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome, 2020, American Journal of Physiology-Gastrointestinal and Liver Physiology
  • Redox Imbalance and Methylation Disturbances in Early Childhood Obesity, 2021, Oxidative Medicine and Cellular Longevity
  • Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation, 2020, International Journal of Radiation Oncology*Biology*Physics

Their collaboration network includes frequent co-authors such as Yurii Melnyk, Halyna Mahorivska, Igor Koturbash, S. Jill James, and Rupak Pathak, indicating interdisciplinary teamwork in their research projects.

Stepan Melnyk has published extensively in a range of scientific venues. These include:

  • Bulletin of the National Technical University "KhPI" Series New solutions in modern technologies
  • Scientific news of Dahl university
  • UNC Libraries
  • Voprosy Khimii i Khimicheskoi Tekhnologii
  • Chemistry & Chemical Technology

The diversity of publication venues and co-authorship patterns highlights a multifaceted research approach, combining experimental, clinical, and engineering perspectives. This cross-disciplinary engagement is consistent with their work in biomedical engineering and related fields.

Best Publications

  • Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism

    S Jill James;Paul Cutler;Stepan Melnyk;Stefanie Jernigan

  • Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation*

    Ping Yi;Stepan Melnyk;Marta Pogribna;Igor P. Pogribny

  • Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

    Zhoutao Chen;Andrew C. Karaplis;Susan L. Ackerman;Igor P. Pogribny

  • Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism

    S. Jill James;Stepan Melnyk;Stefanie Jernigan;Mario A. Cleves

  • Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome

    S Jill James;Marta Pogribna;Igor P Pogribny;Stepan Melnyk

  • Elevation in S-Adenosylhomocysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology

    S. Jill James;Stepan Melnyk;Marta Pogribna;Igor P. Pogribny

  • Intracellular S-Adenosylhomocysteine Concentrations Predict Global DNA Hypomethylation in Tissues of Methyl-Deficient Cystathionine β-Synthase Heterozygous Mice

    Marie A. Caudill;Jennie C. Wang;Stepan Melnyk;Igor P. Pogribny

  • Homocysteine Metabolism in Children with Down Syndrome: In Vitro Modulation

    Marta Pogribna;Stepan Melnyk;Igor Pogribny;Abalo Chango

  • Measurement of Plasma and Intracellular S–Adenosylmethionine and S–Adenosylhomocysteine Utilizing Coulometric Electrochemical Detection: Alterations with Plasma Homocysteine and Pyridoxal 5'–Phosphate. Concentrations

    Stepan Melnyk;Marta Pogribna;Igor P. Pogribny;Ping Yi

  • Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder

    R E Frye;S Melnyk;D F MacFabe

  • Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism

    S. Jill James;Shannon Rose;Stepan Melnyk;Stefanie Jernigan

  • Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism

    Stepan Melnyk;Stepan Melnyk;George J. Fuchs;George J. Fuchs;Eldon Schulz;Eldon Schulz;Maya Lopez;Maya Lopez

  • Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors

    S. J. James;William Slikker;Stepan Melnyk;Elizabeth New

  • A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection.

    S Melnyk;M Pogribna;I Pogribny;R J Hine

  • Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig.

    Charles H. Halsted;Jesus A. Villanueva;Angela M. Devlin;Onni Niemelä

  • Mechanisms of DNA Damage, DNA Hypomethylation, and Tumor Progression in the Folate/Methyl-Deficient Rat Model of Hepatocarcinogenesis

    S. Jill James;Igor P. Pogribny;Marta Pogribna;Barbara J. Miller

  • Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism

    Charlotte A Hobbs;Mario A Cleves;Stepan Melnyk;Weizhi Zhao

  • Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet.

    Igor P. Pogribny;Volodymyr P. Tryndyak;Tetyana V. Bagnyukova;Stepan Melnyk

  • Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.

    Ann M. Winter-Vann;Barton A. Kamen;Martin O. Bergo;Stephen G. Young

  • Letter to the Editor Metabolic Endophenotype and Related Genotypes are Associated With Oxidative Stress in Children With Autism

    S. Jill James;Stepan Melnyk;Stefanie Jernigan;Mario A. Cleves

Frequent Co-Authors

Igor P. Pogribny
Igor P. Pogribny National Center for Toxicological Research
Richard E. Frye
Richard E. Frye Barrow Neurological Institute
Ivan Rusyn
Ivan Rusyn Texas A&M University
Frederick A. Beland
Frederick A. Beland National Center for Toxicological Research
Rima Rozen
Rima Rozen McGill University
Rosalia C. M. Simmen
Rosalia C. M. Simmen University of Arkansas for Medical Sciences
Juergen Hahn
Juergen Hahn Rensselaer Polytechnic Institute
Richard H. Finnell
Richard H. Finnell Baylor College of Medicine
Jacob Selhub
Jacob Selhub Tufts University
Jack A. Hinson
Jack A. Hinson University of Arkansas for Medical Sciences

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