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Biology and Biochemistry

D-Index
73
Citations
19489
World Ranking
5922
National Ranking
2802

Research.com Recognitions

  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Jean C. Shih is affiliated with the University of Southern California in the United States. Their research spans several fields including medicine, biochemistry, genetics and molecular biology, and neuroscience. Within these areas, their work emphasizes molecular biology, psychiatry and mental health, cellular and molecular neuroscience, cardiology and cardiovascular medicine, and pulmonary and respiratory medicine.

Their recent research output includes several publications focused on cancer biology and treatment, neurotransmitter signaling, and glioma therapies. Notable recent papers include:

  • Phase 2 trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer (2020, Prostate Cancer and Prostatic Diseases)
  • Breast cancer and neurotransmitters: emerging insights on mechanisms and therapeutic directions (2023, Oncogene)
  • Neurotransmitter signaling: a new frontier in colorectal cancer biology and treatment (2022, Oncogene)
  • N-Methylpropargylamine-Conjugated Hydroxamic Acids as Dual Inhibitors of Monoamine Oxidase A and Histone Deacetylase for Glioma Treatment (2022, Journal of Medicinal Chemistry)
  • Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma (2023, European Journal of Medicinal Chemistry)

Their research topics concentrate on several areas including cancer, stress, anesthesia, and immune response; cardiac electrophysiology and arrhythmias; ion channel regulation and function; prostate cancer treatment and research; receptor mechanisms and signaling; T-cell and B-cell immunology; and neuroinflammation and neurodegeneration mechanisms.

Jean C. Shih frequently collaborates with several co-authors, including Francesca Battaglin, Joshua Millstein, Priya Jayachandran, Sandra Algaze, and Shivani Soni.

Their work has appeared in various scientific venues, with frequent publications in:

  • Oncogene
  • Pharmaceutical Research
  • Cancer Research
  • Prostate Cancer and Prostatic Diseases
  • Journal of Medicinal Chemistry

In 2007, Jean C. Shih was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

    Olivier Cases;Isabelle Seif;Joseph Grimsby;Patricia Gaspar

  • Monoamine oxidase: from genes to behavior.

    J. C. Shih;K. Chen;M. J. Ridd

  • cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.

    Alfred W. J. Bach;Nancy C. Lan;Deborah L. Johnson;Creed W. Abell

  • Monoamine oxidase inactivation: from pathophysiology to therapeutics.

    Marco Bortolato;Kevin Chen;Jean C Shih

  • A transient placental source of serotonin for the fetal forebrain

    Alexandre Bonnin;Nick Goeden;Kevin Chen;Melissa L. Wilson

  • The mouse cortico-striatal projectome.

    Houri Hintiryan;Nicholas N Foster;Ian Bowman;Maxwell Bay

  • Structure and functional expression of cloned rat serotonin 5HT-2 receptor.

    D. B. Pritchett;A. W. J. Bach;M. Wozny;O. Taleb

  • Human monoamine oxidase A and B genes exhibit identical exon-intron organization.

    Joseph Grimsby;Kevin Chen;Li-Jia Wang;Nancy C. Lan

  • Increased stress response and β–phenylethylamine in MAOB –deficient mice

    Joseph Grimsby;Miklos Toth;Kevin Chen;Takeshi Kumazawa

  • Monoamine oxidase in neuropsychiatry and behavior.

    J.C. Shih;R.F. Thompson

  • The metabolism of tyramine by monoamine oxidase A/B causes oxidative damage to mitochondrial DNA

    Nils Hauptmann;Joseph Grimsby;Jean C. Shih;Enrique Cadenas

  • Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia.

    Jeanette Erdmann;Daphne Shimron-Abarbanell;Marcella Rietschel;Margot Albus

  • Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease.

    Nancy C. Lan;Camilla Heinzmann;Andreas Gal;Ivana Klisak

  • Monoamine Oxidase A–Mediated Enhanced Catabolism of Norepinephrine Contributes to Adverse Remodeling and Pump Failure in Hearts With Pressure Overload

    Nina Kaludercic;Eiki Takimoto;Takahiro Nagayama;Ning Feng

  • The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity.

    Guang Guo;Xiao Ming Ou;Michael Roettger;Jean C. Shih

  • Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis

    Jason Boyang Wu;Chen Shao;Xiangyan Li;Qinlong Li

  • Substrate and Inhibitor Specificities for Human Monoamine Oxidase A and B Are Influenced by a Single Amino Acid

    Rani Maurice Geha;Igor Rebrin;Kevin Chen;Jean Chen Shih

  • Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway

    Xiao-Ming Ou;Kevin Chen;Jean C. Shih

  • Glucocorticoid and Androgen Activation of Monoamine Oxidase A Is Regulated Differently by R1 and Sp1

    Xiao-Ming Ou;Kevin Chen;Jean C. Shih

  • Contributions of the DAT1 and DRD2 genes to serious and violent delinquency among adolescents and young adults

    Guang Guo;Michael E. Roettger;Jean C. Shih

Frequent Co-Authors

Marco Bortolato
Marco Bortolato University of Florida
Isabelle Seif
Isabelle Seif University of Paris-Saclay
David A. Kass
David A. Kass Johns Hopkins University School of Medicine
Karel Pacak
Karel Pacak National Institutes of Health
Fabio Di Lisa
Fabio Di Lisa University of Padua
Paul Greengard
Paul Greengard Rockefeller University
Moussa B.H. Youdim
Moussa B.H. Youdim Technion – Israel Institute of Technology
Lars Oreland
Lars Oreland Uppsala University
Stephanie J. London
Stephanie J. London National Institutes of Health
Robert S. Sparkes
Robert S. Sparkes University of California, Los Angeles

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