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Medicine

D-Index
142
Citations
69683
World Ranking
1571
National Ranking
917

Overview

Jacob Selhub is affiliated with Tufts University in the United States and has contributed extensively to research in Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans topics in Folate and B Vitamins Research, Metabolism and Genetic Disorders, Iron Metabolism and Disorders, Genetics and Neurodevelopmental Disorders, Nuclear Structure and Function, Renal Transplantation Outcomes and Treatments, and Nutritional Studies and Diet.

Selhub has published in several notable venues, with a frequent presence in:

  • UNC Libraries
  • American Journal of Clinical Nutrition
  • Nature Communications
  • Food and Nutrition Bulletin
  • Advances in Nutrition

The research outputs include papers addressing complex metabolic interactions, clinical nutritional impacts, and disease risk factors. Key publications authored or coauthored by Selhub include:

  • Perspective: The High-Folate-Low-Vitamin B-12 Interaction Is a Novel Cause of Vitamin B-12 Depletion with a Specific Etiology-A Hypothesis, 2021, Advances in Nutrition
  • Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop, 2020, American Journal of Clinical Nutrition
  • A prospective birth cohort study on cord blood folate subtypes and risk of autism spectrum disorder, 2020, American Journal of Clinical Nutrition
  • Excess Folic Acid and Vitamin B12 Deficiency: Clinical Implications?, 2024, Food and Nutrition Bulletin
  • Homocysteine-Lowering and Cardiovascular Disease Outcomes in Kidney Transplant Recipients: Primary Results From the Folic Acid for Vascular Outcome Reduction in Transplantation Trial, 2020, UNC Libraries

Selhub's collaborative network includes frequent coauthors such as:

  • Paul F. Jacques
  • Joel B. Mason
  • Joshua W. Miller
  • Aron M. Troen

In their specialized research areas, Selhub addresses the biochemical and clinical relationships underlying folate metabolism and vitamin B-12 status. Their involvement includes studies concerning metabolic and genetic disorders, with a notable focus on rheumatology, molecular biology, public health, hematology, and clinical biochemistry as subfields.

Overall, their scientific contributions emphasize the intersections of nutrition, genetics, and disease outcomes, particularly in relation to folate and vitamin B complex metabolism and impacts on conditions such as autism spectrum disorder and transplant-related cardiovascular outcomes.

Best Publications

  • Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease

    Sudha Seshadri;Alexa Beiser;Jacob Selhub;Paul F Jacques

  • Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

    Jacob Selhub;Paul F. Jacques;Peter W. F. Wilson;David Rush

  • Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis

    R. Clarke;R. Collins;S. Lewington;A. Donald

  • Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

    P. F. Jacques;A. G. Bostom;R. R. Williams;R. C. Ellison

  • Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis

    Jacob Selhub;Paul F. Jacques;Andrew G. Bostom;Ralph B. D'Agostino

  • Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death

    Thomas J. Wang;Philimon Gona;Philimon Gona;Martin G. Larson;Martin G. Larson;Geoffrey H. Tofler

  • The Effect of Folic Acid Fortification on Plasma Folate and Total Homocysteine Concentrations

    Paul F. Jacques;Jacob Selhub;Andrew G. Bostom;Peter W.F. Wilson

  • A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status

    Simonetta Friso;Sang-Woon Choi;Domenico Girelli;Joel B. Mason

  • Methylenetetrahydrofolate Reductase Polymorphism, Dietary Interactions, and Risk of Colorectal Cancer

    Jing Ma;Meir J. Stampfer;Edward Giovannucci;Carmen Artigas

  • Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort

    Paul F Jacques;Andrew G Bostom;Peter Wf Wilson;Sharron Rich

  • Homocysteine as a Predictive Factor for Hip Fracture in Older Persons

    Robert R McLean;Paul F Jacques;Jacob Selhub;Katherine L Tucker

  • Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

    Zhoutao Chen;Andrew C. Karaplis;Susan L. Ackerman;Igor P. Pogribny

  • Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification.

    Martha Savaria Morris;Paul F Jacques;Irwin H Rosenberg;Jacob Selhub

  • The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine.

    Jacob Selhub;Joshua W. Miller

  • Methylenetetrahydrofolate Reductase Polymorphism, Plasma Folate, Homocysteine, and Risk of Myocardial Infarction in US Physicians

    J. Ma;Meir Stampfer;C. H. Hennekens;P. Frosst

  • B vitamins, homocysteine, and neurocognitive function in the elderly

    Jacob Selhub;Laura C Bagley;Joshua Miller;Irwin H Rosenberg

  • Homocysteine and thrombotic disease

    Armando D'Angelo;Jacob Selhub

  • Nonfasting Plasma Total Homocysteine Levels and Stroke Incidence in Elderly Persons: The Framingham Study

    Andrew G. Bostom;Irwin H. Rosenberg;Halit Silbershatz;Paul F. Jacques

  • Unmetabolized Folic Acid in Plasma Is Associated with Reduced Natural Killer Cell Cytotoxicity among Postmenopausal Women

    Aron M. Troen;Breeana Mitchell;Breeana Mitchell;Bess Sorensen;Mark H. Wener

  • Genomic DNA Hypomethylation, a Characteristic of Most Cancers, Is Present in Peripheral Leukocytes of Individuals Who Are Homozygous for the C677T Polymorphism in the Methylenetetrahydrofolate Reductase Gene

    Lori Lathrop Stern;Joel B. Mason;Jacob Selhub;Sang-Woon Choi

Frequent Co-Authors

Paul F. Jacques
Paul F. Jacques Tufts University
Irwin H. Rosenberg
Irwin H. Rosenberg Tufts University
Peter W.F. Wilson
Peter W.F. Wilson Emory University
Walter C. Willett
Walter C. Willett Harvard University
Ralph B. D'Agostino
Ralph B. D'Agostino Wake Forest University
Ramachandran S. Vasan
Ramachandran S. Vasan The University of Texas Health Science Center at San Antonio
David J. Hunter
David J. Hunter Harvard University
Katherine L. Tucker
Katherine L. Tucker University of Massachusetts Lowell
Meir J. Stampfer
Meir J. Stampfer Harvard University
Emelia J. Benjamin
Emelia J. Benjamin Boston University

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