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Biology and Biochemistry

D-Index
53
Citations
13190
World Ranking
15997
National Ranking
1121

Overview

Hartmut Kleinert is affiliated with Johannes Gutenberg University of Mainz in Germany. Their research spans multiple topics primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. The scientist's work significantly covers areas such as Noise Effects and Management, Nitric Oxide and Endothelin Effects, and Eicosanoids and Hypertension Pharmacology. Other notable topics include Climate Change and Health Impacts, RNA Research and Splicing, Neutrophil, Myeloperoxidase and Oxidative Mechanisms, as well as Atherosclerosis and Cardiovascular Diseases.

Their publication record includes frequent contributions to several scientific journals, with multiple publications in Free Radical Biology and Medicine, Cells, and the European Journal of Preventive Cardiology. Other venues where their research appears include Frontiers in Bioscience-Landmark and Redox Biology.

Some recent papers authored or co-authored by Kleinert cover a range of cardiovascular and molecular biology topics:

  • Regulation of NOS expression in vascular diseases, 2021, Frontiers in Bioscience-Landmark
  • Co-exposure to urban particulate matter and aircraft noise adversely impacts the cerebro-pulmonary-cardiovascular axis in mice, 2022, Redox Biology
  • The Role of KH-Type Splicing Regulatory Protein (KSRP) for Immune Functions and Tumorigenesis, 2022, Cells
  • Mitigation of aircraft noise-induced vascular dysfunction and oxidative stress by exercise, fasting, and pharmacological α1AMPK activation: molecular proof of a protective key role of endothelial α1AMPK against environmental noise exposure, 2023, European Journal of Preventive Cardiology
  • Aircraft noise exposure induces pro-inflammatory vascular conditioning and amplifies vascular dysfunction and impairment of cardiac function after myocardial infarction, 2023, Cardiovascular Research

Kleinert has collaborated frequently with several researchers. Notable co-authors include Andreas Daiber, Matthias Oelze, Thomas Münzel, Marin Kuntić, and Omar Hahad. These collaborations often indicate interdisciplinary and multi-institutional research efforts.

Their work addresses complex interactions in physiological and pathological conditions related to vascular functions, oxidative stress, and environmental impacts like noise and pollution. These research interests align with the subfields of Speech and Hearing, Molecular Biology, Immunology, Physiology, and Biochemistry.

Best Publications

  • Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.

    U Förstermann;E I Closs;J S Pollock;M Nakane

  • Regulation of the expression of inducible nitric oxide synthase.

    Hartmut Kleinert;Andrea Pautz;Katrin Linker;Petra M. Schwarz

  • Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III).

    Ulrich Förstermann;Jean-paul Boissel;Hartmut Kleinert

  • Nitric oxide synthase: expression and expressional control of the three isoforms

    Ulrich Förstermann;Hartmut Kleinert

  • Regulation of the expression of inducible nitric oxide synthase

    Andrea Pautz;Julia Art;Susanne Hahn;Sebastian Nowag

  • Regulation of the Expression of Inducible Nitric Oxide Synthase

    Hartmut Kleinert;Petra M Schwarz;Ulrich Förstermann

  • Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control.

    Ulrich Förstermann;Ingolf Gath;Petra Schwarz;Ellen I. Closs

  • Down-regulation of the expression of endothelial NO synthase is likely to contribute to glucocorticoid-mediated hypertension.

    Thomas Wallerath;Klaus Witte;Stephan C. Schäfer;Petra M. Schwarz

  • Estrogens increase transcription of the human endothelial NO synthase gene: analysis of the transcription factors involved.

    Hartmut Kleinert;Thomas Wallerath;Christian Euchenhofer;Irmgard Ihrig-Biedert

  • Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B.

    H Kleinert;C Euchenhofer;I Ihrig-Biedert;U Förstermann

  • Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR.

    Katrin Linker;Andrea Pautz;Marcel Fechir;Thomas Hubrich

  • Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR.

    El-Sayed Akool;Hartmut Kleinert;Farid M. A. Hamada;Mohamed H. Abdelwahab

  • Complex Contribution of the 3′-Untranslated Region to the Expressional Regulation of the Human Inducible Nitric-oxide Synthase Gene INVOLVEMENT OF THE RNA-BINDING PROTEIN HuR

    Fernando Rodriguez-Pascual;Michael Hausding;Irmgard Ihrig-Biedert;Henry Furneaux

  • Activation of Protein Kinase Cα and/or ε Enhances Transcription of the Human Endothelial Nitric Oxide Synthase Gene

    Huige Li;Silke A. Oehrlein;Thomas Wallerath;Irmgard Ihrig-Biedert

  • Cytokine induction of NO synthase II in human DLD‐1 cells: roles of the JAK‐STAT, AP‐1 and NF‐κB‐signaling pathways

    Hartmut Kleinert;Thomas Wallerath;Gerhard Fritz;Irmgard Ihrig-Biedert

  • Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol.

    Ning Xia;Susanne Strand;Frank Schlufter;Daniel Siuda

  • In murine 3T3 fibroblasts, different second messenger pathways resulting in the induction of NO synthase II (iNOS) converge in the activation of transcription factor NF-kappaB.

    Hartmut Kleinert;Christian Euchenhofer;Irmgard Ihrig-Biedert;Ulrich Förstermann

  • Green Tea Inhibits Human Inducible Nitric-Oxide Synthase Expression by Down-Regulating Signal Transducer and Activator of Transcription-1α Activation

    Elisa Tedeschi;Marta Menegazzi;Ying Yao;Hisanori Suzuki

  • Lovastatin inhibits Rho-regulated expression of E-selectin by TNF-α and attenuates tumor cell adhesion

    Tobias Nübel;Wolfgang Dippold;Hartmut Kleinert;Bernd Kaina

  • The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells.

    Elisabeth Ziesché;Malte Bachmann;Hartmut Kleinert;Josef Pfeilschifter

Frequent Co-Authors

Ulrich Förstermann
Ulrich Förstermann Johannes Gutenberg University of Mainz
Andreas Daiber
Andreas Daiber Johannes Gutenberg University of Mainz
Thomas Münzel
Thomas Münzel Johannes Gutenberg University of Mainz
Victoria Kolb-Bachofen
Victoria Kolb-Bachofen Heinrich Heine University Düsseldorf
Josef Pfeilschifter
Josef Pfeilschifter Goethe University Frankfurt
Gerhard Fritz
Gerhard Fritz Johannes Gutenberg University of Mainz
Bernd Kaina
Bernd Kaina Johannes Gutenberg University of Mainz
Carsten Carlberg
Carsten Carlberg University of Eastern Finland
Hisanori Suzuki
Hisanori Suzuki University of Verona
Verena M. Dirsch
Verena M. Dirsch University of Vienna

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