World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
140
Citations
76896
World Ranking
271
National Ranking
185

Medicine

D-Index
140
Citations
76862
World Ranking
1687
National Ranking
975

Overview

William C. Sessa is affiliated with Pfizer in the United States and has contributed extensively to biochemistry, genetics, molecular biology, and medicine. Their research spans multiple specialized fields including molecular biology, cell biology, surgery, cancer research, and physiology.

Their notable scientific contributions cover a diverse range of topics with emphasis on:

  • Cancer, Hypoxia, and Metabolism
  • Nitric Oxide and Endothelin Effects
  • Angiogenesis and VEGF in Cancer
  • Caveolin-1 and cellular processes
  • Peroxisome Proliferator-Activated Receptors
  • Cholesterol and Lipid Metabolism
  • Congenital heart defects research

William C. Sessa has published frequently in several key venues relevant to vascular biology and molecular medicine, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Arteriosclerosis Thrombosis and Vascular Biology
  • Circulation
  • Proceedings of the National Academy of Sciences
  • eLife

Among their recent papers are:

  • "Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis" (2020, Arteriosclerosis Thrombosis and Vascular Biology)
  • "Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia" (2021, Circulation)
  • "Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity" (2022, Circulation)
  • "Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling" (2022, Circulation)
  • "Acetate controls endothelial-to-mesenchymal transition" (2023, Cell Metabolism)

Their frequent collaborators include Nabil E. Boutagy, Joseph W. Fowler, Rong Zhang, Carlos Fernández-Hernando, and Sungwoon Lee, reflecting ongoing cooperation across multiple research projects.

Best Publications

  • Nitric oxide synthases: regulation and function.

    Ulrich Förstermann;William C. Sessa

  • Regulation of endothelium-derived nitric oxide production by the protein kinase Akt.

    David Fulton;Jean Philippe Gratton;Timothy J. McCabe;Jason Fontana

  • Evolving functions of endothelial cells in inflammation

    Jordan S. Pober;William C. Sessa

  • Biological Action of Leptin as an Angiogenic Factor

    M. Rocı́o Sierra-Honigmann;Anjali K. Nath;Chiaki Murakami;Guillermo Garcı́a-Cardeña

  • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

    Yasuko Kureishi;Zhengyu Luo;Ichiro Shiojima;Ann Bialik

  • Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

    Andreas Papapetropoulos;Guillermo García-Cardeña;Joseph A. Madri;William C. Sessa

  • Caveolins, liquid-ordered domains, and signal transduction.

    Eric J. Smart;Gregory A. Graf;Mark A. McNiven;William C. Sessa

  • Dynamic activation of endothelial nitric oxide synthase by Hsp90

    Guillermo García-Cardeña;Guillermo García-Cardeña;Roger Fan;Vijay Shah;Raffaella Sorrentino

  • Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.

    W. C. Sessa;K. Pritchard;Nahid Seyedi;Jie Wang

  • Elevated blood pressures in mice lacking endothelial nitric oxide synthase

    Edward G. Shesely;Nobuyo Maeda;H.-S. Kim;Kaushik M. Desai

  • Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.

    Radu Daniel Rudic;Edward G. Shesely;Nobuyo Maeda;Oliver Smithies

  • Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo

    Guillermo Garcı́a-Cardeña;Pavel Martasek;Bettie Sue Siler Masters;Phillip M. Skidd

  • Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway

    Andreas Papapetropoulos;David Fulton;Keyvan Mahboubi;Robert G. Kalb

  • Dicer Dependent MicroRNAs Regulate Gene Expression and Functions in Human Endothelial Cells

    Yajaira Suárez;Carlos Fernández-Hernando;Jordan S. Pober;William C. Sessa

  • TARGETING OF NITRIC OXIDE SYNTHASE TO ENDOTHELIAL CELL CAVEOLAE VIA PALMITOYLATION : IMPLICATIONS FOR NITRIC OXIDE SIGNALING

    Guillermo Garcia-Cardena;Phil Oh;Jianwei Liu;Jan E. Schnitzer

  • eNOS at a glance

    William C. Sessa

  • Endothelial Nitric Oxide Synthase Is Regulated by Tyrosine Phosphorylation and Interacts with Caveolin-1

    Guillermo García-Cardeña;Roger Fan;David F. Stern;Jianwei Liu

  • 17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization.

    Teresa Caulin-Glaser;G. García-Cardeña;Phillip Sarrel;William C. Sessa

  • In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation

    Mariarosaria Bucci;Jean Philippe Gratton;Radu Daniel Rudic;Lisette Acevedo

  • Membrane Estrogen Receptor Engagement Activates Endothelial Nitric Oxide Synthase via the PI3-Kinase–Akt Pathway in Human Endothelial Cells

    M. Page Haynes;Diviya Sinha;Kerry Strong Russell;Mark Collinge

Frequent Co-Authors

Jun Yu
Jun Yu Chinese University of Hong Kong
David Fulton
David Fulton Augusta University
Roberto J. Groszmann
Roberto J. Groszmann Yale University
Andreas Papapetropoulos
Andreas Papapetropoulos National and Kapodistrian University of Athens
Guillermo García-Cardeña
Guillermo García-Cardeña Brigham and Women's Hospital
Frank J. Giordano
Frank J. Giordano Yale University
Yajaira Suárez
Yajaira Suárez Yale University
Kenneth Walsh
Kenneth Walsh University of Virginia
Themis R. Kyriakides
Themis R. Kyriakides Yale University

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