World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
105
Citations
51337
World Ranking
984
National Ranking
392

Biology and Biochemistry

D-Index
105
Citations
51575
World Ranking
1178
National Ranking
699

Overview

Dennis J. Stuehr is affiliated with the Cleveland Clinic Lerner College of Medicine in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a significant focus on Molecular Biology, Physiology, Cell Biology, Immunology, and Clinical Biochemistry.

Their work concentrates on topics related to Nitric Oxide and Endothelin Effects, Hemoglobin structure and function, Heme Oxygenase-1 and Carbon Monoxide, Neutrophil, Myeloperoxidase and Oxidative Mechanisms, Metabolism and Genetic Disorders, Tryptophan and brain disorders, and Neuroinflammation and Neurodegeneration Mechanisms.

Frequent publication venues for their research include:

  • Journal of Biological Chemistry
  • Redox Biology
  • Free Radical Biology and Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences

Some recent papers authored or co-authored by Dennis J. Stuehr are:

  • GAPDH delivers heme to soluble guanylyl cyclase, 2020, Journal of Biological Chemistry
  • Maturation, inactivation, and recovery mechanisms of soluble guanylyl cyclase, 2021, Journal of Biological Chemistry
  • NO rapidly mobilizes cellular heme to trigger assembly of its own receptor, 2022, Proceedings of the National Academy of Sciences
  • Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase, 2020, Proceedings of the National Academy of Sciences
  • Specific O-GlcNAc modification at Ser-615 modulates eNOS function, 2020, Redox Biology

The scientist has collaborated frequently with co-authors such as:

  • Yue Dai
  • Arnab Ghosh
  • Pranjal Biswas
  • Elizabeth A. Sweeny
  • Dhanya T. Jayaram

Best Publications

  • Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

    A. H. Ding;C. F. Nathan;Dennis J Stuehr

  • Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells

    D J Stuehr;C F Nathan

  • Nitric Oxide Synthases: Properties and Catalytic Mechanism

    O W Griffith;D J Stuehr

  • Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

    Dennis J. Stuehr;Michael A. Marletta

  • Mammalian nitric oxide synthases.

    Dennis J Stuehr

  • Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein

    Dennis J. Stuehr;Hearn J. Cho;Nyoun Soo Kwon;Mary F. Weise

  • Function of Mitochondrial Stat3 in Cellular Respiration

    Joanna Wegrzyn;Ramesh Potla;Yong Joon Chwae;Naresh B.V. Sepuri

  • Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

    Radha Iyengar;Dennis J. Stuehr;Michael A. Marletta

  • Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

    D J Stuehr;M A Marletta

  • Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.

    Brian R. Crane;Brian R. Crane;Andrew S. Arvai;Dipak K. Ghosh;Chaoqun Wu

  • N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

    Dennis J Stuehr;Nyoun Soo Kwon;Carl F. Nathan;Owen W. Griffith

  • STRUCTURE-FUNCTION ASPECTS IN THE NITRIC OXIDE SYNTHASES

    Dennis J. Stuehr

  • Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages

    Nyoun Soo Kwon;C. F. Nathan;D. J. Stuehr

  • Mammalian nitric oxide synthases.

    D J Stuehr;O W Griffith

  • Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo

    F. H. Guo;H. R. De Raeve;T. W. Rice;D. J. Stuehr

  • Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

    Aihao Ding;Carl F. Nathan;Jeannette Graycar;Rik Derynck

  • Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer

    Husam M. Abu-Soud;Dennis J. Stuehr

  • Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.

    D J Stuehr;S S Gross;I Sakuma;R Levi

  • Update on mechanism and catalytic regulation in the NO synthases.

    Dennis J. Stuehr;Jerome Santolini;Zhi Qiang Wang;Chin Chuan Wei

  • Identification of arginine as a precursor of endothelium-derived relaxing factor

    Ichiro Sakuma;Dennis J. Stuehr;Steven S. Gross;Carl Nathan

Frequent Co-Authors

Elizabeth D. Getzoff
Elizabeth D. Getzoff Scripps Research Institute
Carl Nathan
Carl Nathan Cornell University
Brian R. Crane
Brian R. Crane Cornell University
Serpil C. Erzurum
Serpil C. Erzurum Cleveland Clinic Lerner College of Medicine
Denis L. Rousseau
Denis L. Rousseau Albert Einstein College of Medicine
John A. Tainer
John A. Tainer The University of Texas MD Anderson Cancer Center
Russ Hille
Russ Hille University of California, Riverside
John W. Crabb
John W. Crabb Cleveland Clinic
Michael A. Marletta
Michael A. Marletta University of California, Berkeley
Andrew S. Arvai
Andrew S. Arvai Scripps Research Institute

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