D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 62 Citations 16,644 479 World Ranking 5595 National Ranking 1813

Research.com Recognitions

Awards & Achievements

2014 - Fellow of the American Academy of Arts and Sciences

2014 - Fellow, National Academy of Inventors

2013 - Centenary Prize, Royal Society of Chemistry (UK)

2011 - Fellow of the American Chemical Society

2009 - Perkin Medal, Society of Chemical Industry, American Section

1990 - Fellow of the American Association for the Advancement of Science (AAAS)

1981 - Fellow of Alfred P. Sloan Foundation

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Organic chemistry
  • Biochemistry

His primary areas of study are Stereochemistry, Enzyme, Biochemistry, Nitric oxide synthase and Pharmacology. His Stereochemistry research includes elements of Stereoisomerism, Monoamine oxidase B, Active site, Selectivity and Enzyme inhibitor. His work carried out in the field of Enzyme brings together such families of science as Drug, Aminobutyric acid and Vigabatrin.

His Nitric oxide synthase research incorporates elements of Cytoprotective Agent and Heme. His Pharmacology study combines topics in areas such as SIRT2, Sirtuin, Neurodegeneration and Epilepsy. His Drug action study incorporates themes from Prodrug, Virtual screening and Organic chemistry, Drug delivery.

His most cited work include:

  • The Organic Chemistry of Drug Design and Drug Action (1371 citations)
  • Celastrols as inducers of the heat shock response and cytoprotection. (351 citations)
  • Mechanism-based enzyme inactivators. (279 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Stereochemistry, Biochemistry, Enzyme, Nitric oxide synthase and Organic chemistry. The concepts of his Stereochemistry study are interwoven with issues in Monoamine oxidase B, Monoamine oxidase, Active site, Aminobutyric acid and Enzyme inhibitor. He has researched Enzyme inhibitor in several fields, including Biological activity and Chemical synthesis.

His research on Biochemistry often connects related topics like Pharmacology. His Enzyme study integrates concerns from other disciplines, such as Adduct, Vigabatrin and Mechanism of action. The various areas that he examines in his Nitric oxide synthase study include Dipeptide, Arginine, Isozyme and Heme.

He most often published in these fields:

  • Stereochemistry (41.86%)
  • Biochemistry (32.18%)
  • Enzyme (24.86%)

What were the highlights of his more recent work (between 2012-2021)?

  • Biochemistry (32.18%)
  • Stereochemistry (41.86%)
  • Enzyme (24.86%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Biochemistry, Stereochemistry, Enzyme, Nitric oxide synthase and Pharmacology. Structure–activity relationship, Enos, Oxidoreductase, Neuronal Nitric Oxide Synthase and Active site are the core of his Biochemistry study. His research integrates issues of Protein structure and Selectivity in his study of Stereochemistry.

His Enzyme research is multidisciplinary, relying on both Aminobutyric acid, Ornithine aminotransferase and Vigabatrin. His research in Nitric oxide synthase intersects with topics in Bacillus anthracis, Microbiology and Heme. His Pharmacology research focuses on Neurodegeneration and how it relates to Animal studies.

Between 2012 and 2021, his most popular works were:

  • Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain. (90 citations)
  • Target- and Mechanism-Based Therapeutics for Neurodegenerative Diseases: Strength in Numbers (89 citations)
  • The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. (73 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Organic chemistry
  • Biochemistry

His scientific interests lie mostly in Biochemistry, Pharmacology, Nitric oxide synthase, Structure–activity relationship and Nitric oxide. His Biochemistry study frequently draws connections to adjacent fields such as Stereochemistry. His Stereochemistry research incorporates themes from Protein structure and Oxazoline.

His studies in Pharmacology integrate themes in fields like SIRT2, Nucleus accumbens, Dopamine, Neuroscience and Neurodegeneration. His biological study spans a wide range of topics, including Bacillus anthracis, Microbiology, Binding site and Heme. His study in Enzyme is interdisciplinary in nature, drawing from both Cancer, Aminobutyric acid and Vigabatrin.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The Organic Chemistry of Drug Design and Drug Action

Richard B. Silverman.
(1992)

2228 Citations

Mechanism-based enzyme inactivators.

Richard B. Silverman.
Methods in Enzymology (1995)

462 Citations

Celastrols as inducers of the heat shock response and cytoprotection.

Sandy D. Westerheide;Joshua D. Bosman;Bessie N.A. Mbadugha;Tiara L.A. Kawahara.
Journal of Biological Chemistry (2004)

452 Citations

Radical Ideas about Monoamine Oxidase

Richard B. Silverman.
Accounts of Chemical Research (1995)

329 Citations

Mechanism-based enzyme inactivation : chemistry and enzymology

Richard B. Silverman.
(1988)

329 Citations

The organic chemistry of enzyme-catalyzed reactions

Richard B. Silverman.
(2002)

312 Citations

GABA and L-glutamic acid analogs for antiseizure treatment

Richard B. Silverman;Ryszard Andruszkiewicz;Po-Wai Yuen;Denis Martin Sobieray.
(1999)

291 Citations

Potent and selective inhibition of neuronal nitric oxide synthase by N(ω)-propyl-L-arginine

Henry Q. Zhang;Walter Fast;Michael A. Marletta;Pavel Martasek.
Journal of Medicinal Chemistry (1997)

273 Citations

Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule

Amy Trott;James D. West;Lada Klaić;Sandy D. Westerheide.
Molecular Biology of the Cell (2007)

250 Citations

Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin.

Paola Storici;Daniela De Biase;Francesco Bossa;Stefano Bruno.
Journal of Biological Chemistry (2004)

179 Citations

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