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Richard B. Silverman

Richard B. Silverman

D-Index & Metrics

Chemistry

D-Index
67
Citations
19693
World Ranking
6794
National Ranking
2036

Research.com Recognitions

  • 2014 - Fellow, National Academy of Inventors
  • 2014 - Fellow of the American Academy of Arts and Sciences
  • 2013 - Centenary Prize, Royal Society of Chemistry (UK)
  • 2011 - Fellow of the American Chemical Society
  • 2009 - Perkin Medal, Society of Chemical Industry, American Section
  • 1990 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1981 - Fellow of Alfred P. Sloan Foundation

Overview

Richard B. Silverman is affiliated with Northwestern University in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Subfields of particular interest include Molecular Biology, Physiology, Organic Chemistry, Biochemistry, and Neurology.

The scientist's work covers a range of topics that intersect enzymology, metabolism, and neuropharmacology. Main topics include:

  • Amino Acid Enzymes and Metabolism
  • Polyamine Metabolism and Applications
  • Nitric Oxide and Endothelin Effects
  • Neuroscience and Neuropharmacology Research
  • Enzyme Structure and Function
  • Amyotrophic Lateral Sclerosis Research
  • Metal-Catalyzed Oxygenation Mechanisms

Recent published papers illustrate the diversity and scope of their research. Some examples include:

  • "Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP-43 pathology", 2021, Clinical and Translational Medicine
  • "A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid", 2020, Journal of the American Chemical Society
  • "First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate", 2020, Journal of Medicinal Chemistry
  • "Physiological involvement of presynaptic L-type voltage-dependent calcium channels in GABA release of cerebellar molecular layer interneurons", 2020, Journal of Neurochemistry
  • "Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS)", 2022, Scientific Reports

Frequent co-authors in their research include Neil L. Kelleher, Dali Liu, Pathum M. Weerawarna, Peter F. Doubleday, and Arseniy Butrin, indicating a collaborative research environment with repeated partnerships.

The primary venues where this scientist publishes include:

  • ACS Chemical Biology
  • Journal of the American Chemical Society
  • ACS Medicinal Chemistry Letters
  • Journal of Medicinal Chemistry
  • Scientific Reports

Richard B. Silverman has received several awards and recognitions throughout their career, highlighting long-term contributions to the field. These include:

  • Fellow, National Academy of Inventors (2014)
  • Fellow of the American Academy of Arts and Sciences (2014)
  • Centenary Prize, Royal Society of Chemistry (UK) (2013)
  • Fellow of the American Chemical Society (2011)
  • Perkin Medal, Society of Chemical Industry, American Section (2009)
  • Fellow of the American Association for the Advancement of Science (AAAS) (1990)
  • Fellow of Alfred P. Sloan Foundation (1981)

Best Publications

  • The Organic Chemistry of Drug Design and Drug Action

    Richard B. Silverman

  • Inducible Nitric Oxide Synthase: Regulation, Structure, and Inhibition

    Maris A. Cinelli;Ha T. Do;Galen P. Miley;Richard B. Silverman

  • Mechanism-based enzyme inactivators.

    Richard B. Silverman

  • Celastrols as inducers of the heat shock response and cytoprotection.

    Sandy D. Westerheide;Joshua D. Bosman;Bessie N.A. Mbadugha;Tiara L.A. Kawahara

  • Radical Ideas about Monoamine Oxidase

    Richard B. Silverman

  • The organic chemistry of enzyme-catalyzed reactions

    Richard B. Silverman

  • Mechanism-based enzyme inactivation : chemistry and enzymology

    Richard B. Silverman

  • GABA and L-glutamic acid analogs for antiseizure treatment

    Richard B. Silverman;Ryszard Andruszkiewicz;Po-Wai Yuen;Denis Martin Sobieray

  • Potent and selective inhibition of neuronal nitric oxide synthase by N(ω)-propyl-L-arginine

    Henry Q. Zhang;Walter Fast;Michael A. Marletta;Pavel Martasek

  • Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule

    Amy Trott;James D. West;Lada Klaić;Sandy D. Westerheide

  • Design, Synthesis, and Biological Activity of a Difluoro-Substituted, Conformationally Rigid Vigabatrin Analogue as a Potent γ-Aminobutyric Acid Aminotransferase Inhibitor

    Yue Pan;Jian Qiu;Richard B. Silverman

  • The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models

    Vanita Chopra;Luisa Quinti;Jinho Kim;Lorraine Vollor

  • Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin.

    Paola Storici;Daniela De Biase;Francesco Bossa;Stefano Bruno

  • From Basic Science to Blockbuster Drug: The Discovery of Lyrica

    Richard B. Silverman

  • CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease.

    Soosung Kang;Garry Cooper;Sara F. Dunne;Brendon Dusel

  • Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases.

    Richard B. Silverman

  • Target- and Mechanism-Based Therapeutics for Neurodegenerative Diseases: Strength in Numbers

    Paul C. Trippier;Kristin Jansen Labby;Dustin D. Hawker;Jan J. Mataka

  • Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.

    Paramita Mukherjee;Maris A. Cinelli;Soosung Kang;Richard B. Silverman

  • A mechanism for mitochondrial monoamine oxidase catalyzed amine oxidation

    Richard B. Silverman;Stephen J. Hoffman;William B. Catus

  • Syntheses of (S)-5:Substituted 4-Aminopentanoic Acids: A New Class of γ-Aminobutyric Acid Transaminase Inactivators

    Richard B. Silverman;Mark A. Levy

  • The Organic Chemistry of Drug Design and Drug Action: Third Edition

    Richard B. Silverman;Mark W. Holladay

Frequent Co-Authors

Pavel Martásek
Pavel Martásek Charles University
Thomas L. Poulos
Thomas L. Poulos University of California, Irvine
Huiying Li
Huiying Li University of California, Irvine
Richard I. Morimoto
Richard I. Morimoto Northwestern University
David Dolphin
David Dolphin University of British Columbia
Neil L. Kelleher
Neil L. Kelleher Northwestern University
Dimitri Krainc
Dimitri Krainc Northwestern University
Richard B. van Breemen
Richard B. van Breemen Oregon State University
Robert J. Ferrante
Robert J. Ferrante Boston University

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