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D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
57750
World Ranking
4666
National Ranking
2260

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Dimitri Krainc is affiliated with Northwestern University in the United States and has an extensive publication record centered on biochemistry, genetics, and molecular biology, with a significant focus on neurology. Their research addresses key areas within these disciplines, particularly emphasizing Parkinson's disease mechanisms and treatments, cellular transport and secretion, and lysosomal storage disorders.

The main fields of study for their work include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broad fields, their subfields of study encompass:

  • Neurology
  • Molecular Biology
  • Genetics
  • Cell Biology
  • Physiology

The primary research topics covered by Dimitri Krainc's work include:

  • Parkinson's Disease Mechanisms and Treatments
  • Cellular transport and secretion
  • Lysosomal Storage Disorders Research
  • RNA regulation and disease
  • Neurological diseases and metabolism
  • Genetics and Neurodevelopmental Disorders
  • Mitochondrial Function and Pathology

Their frequent coauthors include Steven Lubbe, Bernabé I. Bustos, Niccolò E. Mencacci, Lena F. Burbulla, and Andrew Singleton. These collaborations have contributed to the depth and scope of their scientific output.

Selected recent papers illustrate the focus and impact of their work:

  • "Mitochondria-lysosome contacts regulate mitochondrial Ca2+ dynamics via lysosomal TRPML1," 2020, Proceedings of the National Academy of Sciences
  • "Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson's disease," 2021, Nature Communications
  • "Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation," 2020, Journal of Neuroscience
  • "The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson's Disease," 2020, Frontiers in Cell and Developmental Biology
  • "Dysregulation of organelle membrane contact sites in neurological diseases," 2022, Neuron

Frequent publication venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Movement Disorders
  • Neurology
  • Annals of Neurology
  • Proceedings of the National Academy of Sciences

Dimitri Krainc is recognized as a member of the Association of American Physicians. This association reflects their involvement in professional medical research communities.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

    Emanuela Bonfoco;Dimitri Krainc;Maria Ankarcrona;Pierluigi Nicotera

  • Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice

    Jiandie Lin;Pei Hsuan Wu;Paul T. Tarr;Katrin S. Lindenberg

  • Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

    Joseph R. Mazzulli;You Hai Xu;You Hai Xu;Ying Sun;Ying Sun;Adam L. Knight

  • A call for transparent reporting to optimize the predictive value of preclinical research

    Story C. Landis;Susan G. Amara;Khusru Asadullah;Chris P. Austin

  • Transcriptional repression of PGC-1α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration

    Libin Cui;Hyunkyung Jeong;Fran Borovecki;Christopher N. Parkhurst

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

    Lena F. Burbulla;Lena F. Burbulla;Pingping Song;Joseph R. Mazzulli;Joseph R. Mazzulli;Enrico Zampese

  • Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington's Disease

    Anthone W. Dunah;Hyunkyung Jeong;April Griffin;Yong Man Kim

  • Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

    Justine D. Miller;Yosif M. Ganat;Sarah Kishinevsky;Robert L. Bowman

  • α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

    Yvette C Wong;Dimitri Krainc

  • Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

    Yvette C. Wong;Daniel Ysselstein;Dimitri Krainc

  • Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration

    Patrick Weydt;Victor V. Pineda;Anne E. Torrence;Randell T. Libby

  • Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease

    Oliver Cooper;Hyemyung Seo;Shaida Andrabi;Cristina Guardia-Laguarta

  • Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons

    Chee Yeun Chung;Vikram Khurana;Vikram Khurana;Pavan K. Auluck;Pavan K. Auluck;Daniel F. Tardiff

  • Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease

    F. Borovecki;L. Lovrecic;J. Zhou;H. Jeong

  • Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

    Hyunkyung Jeong;Florian Then;Thomas J. Melia;Joseph R. Mazzulli

  • Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

    Ruth Luthi-Carter;Sarah A. Hanson;Andrew D. Strand;Donald A. Bergstrom

Frequent Co-Authors

Christine Klein
Christine Klein University of Lübeck
Richard B. Silverman
Richard B. Silverman Northwestern University
Sergio Lavandero
Sergio Lavandero University of Chile
Rejko Krüger
Rejko Krüger University of Luxembourg
Evelina Gatti
Evelina Gatti Aix-Marseille University
Guy A. Caldwell
Guy A. Caldwell University of Alabama
Steven Finkbeiner
Steven Finkbeiner University of California, San Francisco
Paul Saftig
Paul Saftig Kiel University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Shazib Pervaiz
Shazib Pervaiz National University of Singapore

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