Guy A. Caldwell

Overview

Best Publications

• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

  Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  10661
  Citations

• α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models

  Antony A. Cooper;Aaron D. Gitler;Anil Cashikar;Cole M. Haynes

  1640
  Citations

• Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

  Joseph R. Mazzulli;You Hai Xu;You Hai Xu;Ying Sun;Ying Sun;Adam L. Knight

  1353
  Citations

• The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

  Aaron D. Gitler;Brooke J. Bevis;James Shorter;Katherine E. Strathearn

  628
  Citations

• Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.

  Aaron D Gitler;Alessandra Chesi;Melissa L Geddie;Katherine E Strathearn

  602
  Citations

• Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast

  Sebastian Treusch;Shusei Hamamichi;Shusei Hamamichi;Jessica L. Goodman;Kent E. S. Matlack

  429
  Citations

• Lysosomal impairment in Parkinson's disease.

  Benjamin Dehay;Marta Martinez-Vicente;Guy A. Caldwell;Kim A. Caldwell

  381
  Citations

• Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model.

  Shusei Hamamichi;Renee N. Rivas;Adam L. Knight;Songsong Cao

  347
  Citations

• Torsin-Mediated Protection from Cellular Stress in the Dopaminergic Neurons of Caenorhabditis elegans

  Songsong Cao;Christopher C Gelwix;Kim A Caldwell;Guy A Caldwell

  329
  Citations

• Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

  Daniel F. Tardiff;Nathan T. Jui;Vikram Khurana;Vikram Khurana;Mitali A. Tambe

  284
  Citations

• Potentiated Hsp104 Variants Antagonize Diverse Proteotoxic Misfolding Events

  Meredith E. Jackrel;Morgan E. DeSantis;Bryan A. Martinez;Laura M. Castellano

  281
  Citations

• Deletion of the Ubiquitin Ligase CHIP Leads to the Accumulation, But Not the Aggregation, of Both Endogenous Phospho- and Caspase-3-Cleaved Tau Species

  Chad A. Dickey;Mei Yue;Wen Lang Lin;Dennis W. Dickson

  277
  Citations

• Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

  Liyan Qiao;Shusei Hamamichi;Kim A Caldwell;Guy A Caldwell

  267
  Citations

• Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration.

  Danielle Emille Mor;Elpida Tsika;Joseph R Mazzulli;Neal S Gould

  243
  Citations

• Using Caenorhabditis elegans to probe toxicity of 1-alkyl-3-methylimidazolium chloride based ionic liquids

  Richard P. Swatloski;John D. Holbrey;Shermeen B. Memon;Guy A. Caldwell

  239
  Citations

• Compounds from an Unbiased Chemical Screen Reverse Both Er-to-Golgi Trafficking Defects and Mitochondrial Dysfunction in Parkinson's Disease Models

  Linhui Julie Su;Linhui Julie Su;Pavan K. Auluck;Pavan K. Auluck;Tiago Fleming Outeiro;Tiago Fleming Outeiro;Esti Yeger-Lotem;Esti Yeger-Lotem

  220
  Citations

• Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity

  Kent E. S. Matlack;Daniel F. Tardiff;Priyanka Narayan;Shusei Hamamichi

  180
  Citations

• Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene.

  R Ben-Yaacov;S Knoller;G A Caldwell;J M Becker

  175
  Citations

• Yeast Reveal a ‘Druggable’ Rsp5/Nedd4 Network That Ameliorates α-Synuclein Toxicity in Neurons

  Nathan T. Jui;Stephen Leffler Buchwald;Susan Lindquist;Daniel F. Tardiff

  1
  Citations

• Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

  J. M. Shulman;A. Parrado;M. Lindhagen-Persson;E. M. Reiman

  0
  Citations