What is he best known for?
The fields of study he is best known for:
The scientist’s investigation covers issues in Cell biology, Biochemistry, Caenorhabditis elegans, Alpha-synuclein and Neurodegeneration.
His work carried out in the field of Cell biology brings together such families of science as Endocytic cycle, Parkinson's disease and Yeast.
His research in Caenorhabditis elegans intersects with topics in Mutation and Combinatorial chemistry.
Guy A. Caldwell is interested in Synucleinopathies, which is a field of Alpha-synuclein.
Guy A. Caldwell focuses mostly in the field of Neurodegeneration, narrowing it down to matters related to Neuroprotection and, in some cases, Lewy body, Cathepsin D, Downregulation and upregulation, Neuronal ceroid lipofuscinosis and Dopaminergic.
In the subject of general Glucocerebrosidase, his work in Glucosylceramidase is often linked to Glucosylceramides, thereby combining diverse domains of study.
His most cited work include:
- α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models (1102 citations)
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies (782 citations)
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies (782 citations)
What are the main themes of his work throughout his whole career to date?
Guy A. Caldwell spends much of his time researching Cell biology, Neurodegeneration, Caenorhabditis elegans, Biochemistry and Neuroscience.
His Cell biology research is multidisciplinary, incorporating elements of PINK1 and Alpha-synuclein.
His studies deal with areas such as Proteotoxicity and Amyloid as well as Alpha-synuclein.
His biological study spans a wide range of topics, including Neurotoxicity, Dopaminergic, Parkinson's disease, Neuroprotection and Proteostasis.
His studies in Caenorhabditis elegans integrate themes in fields like RNA interference, Movement disorders, Disease and Transgene.
The Neuroscience study combines topics in areas such as GABAergic and Identification.
He most often published in these fields:
- Cell biology (66.85%)
- Neurodegeneration (53.93%)
- Caenorhabditis elegans (51.12%)
What were the highlights of his more recent work (between 2015-2021)?
- Neurodegeneration (53.93%)
- Cell biology (66.85%)
- Caenorhabditis elegans (51.12%)
In recent papers he was focusing on the following fields of study:
Guy A. Caldwell focuses on Neurodegeneration, Cell biology, Caenorhabditis elegans, Dopaminergic and Neuroscience.
His work deals with themes such as Neurotoxicity, Transgene, Parkinson's disease, Alpha-synuclein and Endocytic cycle, which intersect with Neurodegeneration.
His Cell biology research includes elements of Substantia nigra and Neuroprotection.
Guy A. Caldwell has included themes like Fibril, Biophysics, Small molecule and Nordihydroguaiaretic acid in his Caenorhabditis elegans study.
His Dopaminergic research is multidisciplinary, incorporating elements of Neurotoxin, Toxicant, Gfp reporter and Proteasome.
His Neuroscience research incorporates elements of RNA interference, Genetically modified mouse, Disease and Proteostasis.
Between 2015 and 2021, his most popular works were:
- Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration. (92 citations)
- Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease (44 citations)
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) (38 citations)
In his most recent research, the most cited papers focused on:
Guy A. Caldwell mainly investigates Neurodegeneration, Caenorhabditis elegans, Cell biology, Neuroscience and Dopaminergic.
In Neurodegeneration, Guy A. Caldwell works on issues like Mitochondrion, which are connected to Neurotoxicity, PINK1, Unfolded protein response and Proteostasis.
His work in the fields of Cell biology, such as Retromer, overlaps with other areas such as Ferroportin.
His Neuroscience research is multidisciplinary, incorporating perspectives in Organism, RNA interference, Human disease and Alpha-synuclein.
His Alpha-synuclein study combines topics in areas such as Phenotype, Mitochondrial unfolded protein response, Transgene and Mitophagy.
Guy A. Caldwell works mostly in the field of Dopaminergic, limiting it down to topics relating to Parkinson's disease and, in certain cases, Bioinformatics, Genomics and Nematode caenorhabditis elegans, as a part of the same area of interest.
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