World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
76
Citations
31114
World Ranking
1800
National Ranking
826

Research.com Recognitions

  • 2019 - Sheila Essey Award for ALS Research, American Academy of Neurology

Overview

Aaron D. Gitler is affiliated with Stanford University in the United States. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine, with significant focus on molecular biology, neurology, genetics, cellular and molecular neuroscience, and physiology.

The scientist's work addresses several core topics, including:

  • Amyotrophic Lateral Sclerosis Research
  • RNA Research and Splicing
  • Neurogenetic and Muscular Disorders Research
  • Genetic Neurodegenerative Diseases
  • RNA and protein synthesis mechanisms
  • Mitochondrial Function and Pathology
  • Alzheimer's disease research and treatments

Recent publications authored or co-authored by Aaron D. Gitler demonstrate a focus on neurodegenerative conditions and cellular mechanisms. Key papers include:

  • "Neurotoxic reactive astrocytes induce cell death via saturated lipids" (2021, Nature)
  • "TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A" (2022, Nature)
  • "ALS Genetics: Gains, Losses, and Implications for Future Therapies" (2020, Neuron)
  • "Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model" (2020, Nature Communications)
  • "Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons" (2021, Nature Neuroscience)

Frequent collaborators in their work include:

  • Jacob A. Blum
  • Steven Boeynaems
  • Garam Kım
  • Leonard Petrucelli
  • Tetsuya Akiyama

The scientist's research outputs are published extensively in several venues with multiple contributions, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Neuron
  • SSRN Electronic Journal
  • Nature

Aaron D. Gitler received the Sheila Essey Award for ALS Research from the American Academy of Neurology in 2019. The award recognizes contributions relevant to amyotrophic lateral sclerosis, reflecting the scientist's engagement with this research area.

Best Publications

  • α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models

    Antony A. Cooper;Aaron D. Gitler;Anil Cashikar;Cole M. Haynes

  • Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

    Hong Joo Kim;Nam Chul Kim;Yong Dong Wang;Emily A. Scarborough

  • Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

    Andrew C. Elden;Hyung Jun Kim;Michael P. Hart;Alice S. Chen-Plotkin

  • Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

    Elizabeth T. Cirulli;Brittany N Lasseigne;Slave Petrovski;Peter C Sapp

  • Stress granules as crucibles of ALS pathogenesis

    Yun R. Li;Yun R. Li;Oliver D. King;James Shorter;Aaron D. Gitler

  • TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity

    Brian S. Johnson;David Snead;Jonathan J. Lee;J. Michael McCaffery

  • The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

    Oliver D. King;Aaron D. Gitler;James Shorter

  • Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Alan E. Renton;Nicola Ticozzi

  • Neurodegenerative disease: models, mechanisms, and a new hope.

    Aaron D. Gitler;Paraminder Dhillon;James Shorter

  • Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

    Ana Jovičić;Jerome Mertens;Steven Boeynaems;Steven Boeynaems;Elke Bogaert;Elke Bogaert

  • The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

    Aaron D. Gitler;Brooke J. Bevis;James Shorter;Katherine E. Strathearn

  • Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.

    Aaron D Gitler;Alessandra Chesi;Melissa L Geddie;Katherine E Strathearn

  • Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

    Lindsay A. Becker;Brenda Huang;Gregor Bieri;Rosanna Ma

  • A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae.

    Simon Alberti;Aaron D. Gitler;Susan Lindquist;Susan Lindquist

  • Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS

    Zhihui Sun;Zamia Diaz;Xiaodong Fang;Michael P. Hart

  • Defects in trafficking bridge Parkinson's disease pathology and genetics.

    Asa Abeliovich;Aaron D. Gitler

  • A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

    Brian S. Johnson;J. Michael McCaffery;Susan Lindquist;Aaron D. Gitler

  • A yeast functional screen predicts new candidate ALS disease genes

    Julien Couthouis;Michael P. Hart;James Shorter;Mariely DeJesus-Hernandez

  • Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties.

    Steven Boeynaems;Alex S. Holehouse;Venera Weinhardt;Venera Weinhardt;Denes Kovacs

  • Semaphorin-plexin signaling guides patterning of the developing vasculature.

    Jesús Torres-Vázquez;Aaron D Gitler;Sherri D Fraser;Jason D Berk

Frequent Co-Authors

James Shorter
James Shorter University of Pennsylvania
Nancy M. Bonini
Nancy M. Bonini University of Pennsylvania
Jonathan A. Epstein
Jonathan A. Epstein University of Pennsylvania
Oliver D. King
Oliver D. King University of Massachusetts Chan Medical School
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Guy A. Rouleau
Guy A. Rouleau Montreal Neurological Institute and Hospital
Rosa Rademakers
Rosa Rademakers University of Antwerp
J. Paul Taylor
J. Paul Taylor St. Jude Children's Research Hospital
Peter M Andersen
Peter M Andersen Umeå University

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