World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
116
Citations
42137
World Ranking
768
National Ranking
483

Medicine

D-Index
116
Citations
43611
World Ranking
4399
National Ranking
2403

Research.com Recognitions

  • 2008 - Member of the National Academy of Medicine (NAM)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Jonathan A. Epstein is affiliated with the University of Pennsylvania in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology. The scientist's work notably intersects with molecular biology, cardiology and cardiovascular medicine, surgery, oncology, and genetics.

Their research topics include:

  • Cardiac Fibrosis and Remodeling
  • Genomics and Chromatin Dynamics
  • Epigenetics and DNA Methylation
  • CAR-T Cell Therapy Research
  • Viral Infections and Immunology Research
  • Cardiac Structural Anomalies and Repair
  • Tissue Engineering and Regenerative Medicine

Jonathan A. Epstein has contributed to several recent publications, including:

  • CAR T therapy beyond cancer: the evolution of a living drug, 2023, Nature
  • β-Hydroxybutyrate suppresses colorectal cancer, 2022, Nature
  • Immune Cells and Immunotherapy for Cardiac Injury and Repair, 2021, Circulation Research
  • SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry, 2022, Nature
  • CAR-based therapies: opportunities for immuno-medicine beyond cancer, 2022, Nature Metabolism

The scientist frequently publishes in these venues:

  • Nature
  • UNC Libraries
  • Circulation Research
  • Science Advances
  • Developmental Biology

Frequent co-authors of Jonathan A. Epstein include:

  • Yemin Lan
  • Andrey Poleshko
  • Joel G. Rurik
  • Anna A. Kiseleva
  • Cheryl L. Smith

In addition to research contributions, Jonathan A. Epstein has been recognized by professional organizations. The scientist was made a member of the National Academy of Medicine (NAM) in 2008 and is a member of the Association of American Physicians.

Best Publications

  • Highly Efficient miRNA-Mediated Reprogramming of Mouse and Human Somatic Cells to Pluripotency

    Frederick Anokye-Danso;Chinmay M. Trivedi;Denise Juhr;Mudit Gupta

  • TBX1 Is Responsible for Cardiovascular Defects in Velo-Cardio-Facial/DiGeorge Syndrome

    Sandra Merscher;Birgit Funke;Jonathan A. Epstein;Joerg Heyer

  • Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.

    Brigid L.M. Hogan;Christina E. Barkauskas;Harold A. Chapman;Jonathan A. Epstein

  • Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

    Norifumi Takeda;Rajan Jain;Matthew R. LeBoeuf;Qiaohong Wang

  • A review of guidelines for cross-cultural adaptation of questionnaires could not bring out a consensus

    Jonathan Epstein;Ruth Miyuki Santo;Francis Guillemin

  • Getting your Pax straight: Pax proteins in development and disease.

    Neil Chi;Jonathan A Epstein

  • Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.

    Chinmay M Trivedi;Yang Luo;Yang Luo;Zhan Yin;Zhan Yin;Maozhen Zhang;Maozhen Zhang

  • Targeting cardiac fibrosis with engineered T cells.

    Haig Aghajanian;Toru Kimura;Joel G. Rurik;Aidan S. Hancock

  • Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding.

    H. E. Xu;M. A. Rould;Wenqing Xu;J. A. Epstein

  • A Microfabricated Platform to Measure and Manipulate the Mechanics of Engineered Cardiac Microtissues

    Thomas Boudou;Wesley R. Legant;Anbin Mu;Michael A. Borochin

  • Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

    Toshiyuki Araki;M Golam Mohi;Fraz A Ismat;Roderick T Bronson

  • Cardiovascular disease in neurofibromatosis 1: report of the NF1 Cardiovascular Task Force.

    J M Friedman;Jack Arbiser;Jonathan A Epstein;David H Gutmann

  • Pax3 functions at a nodal point in melanocyte stem cell differentiation

    Deborah Lang;Min Min Lu;Li Huang;Kurt A. Engleka

  • Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types

    Kyle M. Loh;Angela Chen;Pang Wei Koh;Tianda Z. Deng

  • Pax3 modulates expression of the c-Met receptor during limb muscle development.

    Jonathan A. Epstein;David N. Shapiro;Jane Cheng;Paula Y. P. Lam

  • Semaphorin-plexin signaling guides patterning of the developing vasculature.

    Jesús Torres-Vázquez;Aaron D Gitler;Sherri D Fraser;Jason D Berk

  • Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing.

    Jonathan A. Epstein;Thomas M Glaser;Jiexing Cai;Lisa Jepeal

  • Inhibition of Histone Deacetylation Blocks Cardiac Hypertrophy Induced by Angiotensin II Infusion and Aortic Banding

    Hae Jin Kee;Il Suk Sohn;Kwang Il Nam;Jong Eun Park

  • PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.

    Aaron D Gitler;Min Min Lu;Jonathan A Epstein

  • Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes.

    Jonathan Epstein;Jiexing Cai;Thomas M Glaser;Lisa Jepeal

Frequent Co-Authors

Min Min Lu
Min Min Lu University of Pennsylvania
Francis Guillemin
Francis Guillemin University of Lorraine
Aaron D. Gitler
Aaron D. Gitler Stanford University
Clayton A. Buck
Clayton A. Buck The Wistar Institute
Edward E. Morrisey
Edward E. Morrisey University of Pennsylvania
Michael S. Parmacek
Michael S. Parmacek University of Pennsylvania
A. Thomas Look
A. Thomas Look Harvard University
Kenneth B. Margulies
Kenneth B. Margulies University of Pennsylvania
Richard L. Maas
Richard L. Maas Brigham and Women's Hospital
Bernice E. Morrow
Bernice E. Morrow Albert Einstein College of Medicine

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