World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
132
Citations
65400
World Ranking
381
National Ranking
251

Medicine

D-Index
133
Citations
66195
World Ranking
2229
National Ranking
1258

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

A. Thomas Look is affiliated with Harvard University in the United States. Their research spans the fields of biochemistry, genetics, and molecular biology, with significant contributions also in medicine. The scientist's work predominantly focuses on molecular biology and neurology, along with notable involvements in genetics, cancer research, and hematology.

The main topics explored throughout Look's career include:

  • Neuroblastoma research and treatments
  • Protein degradation and inhibitors
  • Ubiquitin and proteasome pathways
  • Epigenetics and DNA methylation
  • Acute myeloid leukemia research
  • Cancer, hypoxia, and metabolism
  • Lymphoma diagnosis and treatment

Look has published extensively, with frequent contributions to several scientific journals. The most common venues include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Advances
  • Leukemia
  • Blood

Some of the recent papers authored or coauthored by A. Thomas Look reflect ongoing investigations in cancer biology and molecular mechanisms:

  • "EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma," 2021, published in Cancer Discovery
  • "Discovery of a Selective Inhibitor of Doublecortin Like Kinase 1," 2020, published in Nature Chemical Biology
  • "ARID1A Loss in Neuroblastoma Promotes the Adrenergic-to-Mesenchymal Transition by Regulating Enhancer-Mediated Gene Expression," 2020, published in Science Advances
  • "RETRACTED: Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2," 2020, published in Cell
  • "Discovery of Regulatory Noncoding Variants in Individual Cancer Genomes by Using cis-X," 2020, published in Nature Genetics

Frequent coauthors collaborating with Look on scientific publications include:

  • Mark W. Zimmerman
  • Brian J. Abraham
  • Adam D. Durbin
  • Shuning He
  • Alla Berezovskaya

A. Thomas Look received recognition as a Fellow of the American Association for the Advancement of Science (AAAS) in 2012.

Best Publications

  • Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

    Andrew P. Weng;Andrew P. Weng;Adolfo A. Ferrando;Adolfo A. Ferrando;Woojoong Lee;Woojoong Lee;John P. Morris;John P. Morris

  • Acute lymphoblastic leukaemia

    Ching-Hon Pui;Leslie L Robison;A Thomas Look

  • The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

    Charles J. Sherr;Carl W. Rettenmier;Rosalba Sacca;Martine F Roussel

  • A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

    Philipp Niethammer;Clemens Grabher;Clemens Grabher;A. Thomas Look;Timothy J. Mitchison

  • Oncogenic Transcription Factors in the Human Acute Leukemias

    A. Thomas Look

  • Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

    Adolfo A Ferrando;Donna S Neuberg;Jane Staunton;Mignon L Loh

  • Human aminopeptidase N is a receptor for human coronavirus 229E

    C L Yeager;R A Ashmun;R K Williams;C B Cardellichio

  • NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

    Teresa Palomero;Wei Keat Lim;Duncan T. Odom;Maria Luisa Sulis

  • Activating mutations in ALK provide a therapeutic target in neuroblastoma

    Rani E. George;Takaomi Sanda;Megan C. Hanna;Stefan Fröhling

  • Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

    Nicholas Kwiatkowski;Tinghu Zhang;Peter B. Rahl;Brian J Abraham

  • An Oncogenic Super-Enhancer Formed Through Somatic Mutation of a Noncoding Intergenic Element

    Marc R. Mansour;Marc R. Mansour;Brian J. Abraham;Lars Anders;Alla Berezovskaya

  • FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

    Jennifer O'Neil;Jonathan Grim;Peter Strack;Sudhir Rao

  • BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma

    E.Elizabeth Patton;Hans R. Widlund;Jeffery L. Kutok;Kamden R. Kopani;Kamden R. Kopani

  • Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study.

    A T Look;F A Hayes;J J Shuster;E C Douglass

  • The use of zebrafish to understand immunity

    Nikolaus S Trede;David M Langenau;David Traver;A.Thomas Look

  • Chromosome 1p and 11q deletions and outcome in neuroblastoma.

    Edward F. Attiyeh;Wendy B. London;Yael P. Mossé;Qun Wang

  • tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

    Stéphane Berghmans;Ryan D. Murphey;Erno Wienholds;Donna Neuberg

  • Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

    Clemens Grabher;Harald von Boehmer;A. Thomas Look

  • Myc-induced T cell leukemia in transgenic zebrafish.

    David M. Langenau;David Traver;Adolfo A. Ferrando;Jeffery L. Kutok

  • Evidence for an Age Cutoff Greater Than 365 Days for Neuroblastoma Risk Group Stratification in the Children's Oncology Group

    W.B. London;R.P. Castleberry;K.K. Matthay;A.T. Look

Frequent Co-Authors

Donna Neuberg
Donna Neuberg Harvard University
John M. Maris
John M. Maris Children's Hospital of Philadelphia
Leonard I. Zon
Leonard I. Zon Harvard University
David M. Langenau
David M. Langenau Harvard University
Lewis B. Silverman
Lewis B. Silverman Harvard University
Jon C. Aster
Jon C. Aster Harvard Medical School
Jeffery L. Kutok
Jeffery L. Kutok Epizyme (United States)
Susan L. Cohn
Susan L. Cohn University of Chicago
Stephen E. Sallan
Stephen E. Sallan Harvard University

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