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Stephen C. Blacklow

Stephen C. Blacklow

D-Index & Metrics

Molecular Biology

D-Index
85
Citations
28333
World Ranking
848
National Ranking
447

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Stephen C. Blacklow is affiliated with Harvard University in the United States and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with a substantial focus on medicine. Their research spans several subfields including molecular biology, cell biology, immunology, radiology, nuclear medicine and imaging, as well as oncology.

The scientist's work addresses a variety of topics, among them:

  • Developmental Biology and Gene Regulation
  • Monoclonal and Polyclonal Antibodies Research
  • Cell Adhesion Molecules Research
  • Epigenetics and DNA Methylation
  • Peptidase Inhibition and Analysis
  • Genomics and Chromatin Dynamics
  • Receptor Mechanisms and Signaling

Frequent publication venues for Stephen C. Blacklow include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biopolymers
  • eLife
  • Nature
  • Nature Chemical Biology

Selected recent papers authored include:

  • "Biophysics of Notch Signaling," 2021, Annual Review of Biophysics
  • "Design of biologically active binary protein 2D materials," 2021, Nature
  • "Development of a covalent inhibitor of gut bacterial bile salt hydrolases," 2020, Nature Chemical Biology
  • "Pharmacological disruption of the Notch transcription factor complex," 2020, Proceedings of the National Academy of Sciences
  • "Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81," 2021, Science

Stephen C. Blacklow has collaborated frequently with a number of researchers, including:

  • Jon C. Aster
  • Julia M. Rogers
  • Emily D. Egan
  • Andrew C. Kruse
  • Colin H. Lipper

Stephen C. Blacklow is recognized as a member of the Association of American Physicians, an acknowledgment of professional achievement.

Best Publications

  • Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

    Andrew P. Weng;Andrew P. Weng;Adolfo A. Ferrando;Adolfo A. Ferrando;Woojoong Lee;Woojoong Lee;John P. Morris;John P. Morris

  • A trimeric structural domain of the HIV-1 transmembrane glycoprotein.

    Min Lu;Stephen C. Blacklow;Stephen C. Blacklow;Peter S. Kim

  • c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

    Andrew P. Weng;John M. Millholland;Yumi Yashiro-Ohtani;Marie Laure Arcangeli

  • Direct inhibition of the NOTCH transcription factor complex

    Raymond E. Moellering;Raymond E. Moellering;Melanie Cornejo;Tina N. Davis;Cristina Del Bianco

  • MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.

    Lizi Wu;Jon C. Aster;Stephen C. Blacklow;Robert Lake

  • The Varied Roles of Notch in Cancer

    Jon C. Aster;Warren S. Pear;Stephen C. Blacklow

  • Calcium depletion dissociates and activates heterodimeric notch receptors.

    Matthew D. Rand;Lisa M. Grimm;Spyros Artavanis-Tsakonas;Vytas Patriub

  • Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

    Yunsun Nam;Piotr Sliz;Luyan Song;Jon C. Aster

  • Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.

    Andrew P. Weng;Yunsun Nam;Michael S. Wolfe;Warren S. Pear

  • Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.

    Nicholas J. Wang;Zachary Sanborn;Kelly L. Arnett;Laura J. Bayston

  • Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module.

    Deborah Fass;Stephen Blacklow;Stephen Blacklow;Peter S. Kim;James M. Berger

  • Structural basis for autoinhibition of Notch

    Wendy R Gordon;Didem Vardar-Ulu;Didem Vardar-Ulu;Gavin Histen;Cheryll Sanchez-Irizarry

  • Notch Directly Regulates Gata3 Expression during T Helper 2 Cell Differentiation

    Terry C. Fang;Yumi Yashiro-Ohtani;Cristina Del Bianco;Dawson M. Knoblock

  • STRUCTURE AND PHYSIOLOGIC FUNCTION OF THE LOW-DENSITY LIPOPROTEIN RECEPTOR

    Hyesung Jeon;Stephen C. Blacklow

  • Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation.

    Natalia Beglova;Stephen C. Blacklow;Junichi Takagi;Timothy A. Springer

  • Notch signaling in leukemia.

    Jon C. Aster;Warren S. Pear;Stephen C. Blacklow

  • Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.

    Wendy R. Gordon;Brandon Zimmerman;Li He;Laura J. Miles

  • Programming peptidomimetic syntheses by translating genetic codes designed de novo

    Anthony C. Forster;Zhongping Tan;Madhavi N. L. Nalam;Hening Lin

  • The molecular logic of Notch signaling – a structural and biochemical perspective

    Wendy R. Gordon;Kelly L. Arnett;Stephen C. Blacklow

  • A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.

    Peter W. Kim;Zhen-Yu J. Sun;Zhen-Yu J. Sun;Stephen C. Blacklow;Stephen C. Blacklow;Gerhard Wagner;Gerhard Wagner

Frequent Co-Authors

Jon C. Aster
Jon C. Aster Harvard Medical School
Warren S. Pear
Warren S. Pear University of Pennsylvania
Jarrod A. Marto
Jarrod A. Marto Harvard University
James E. Bradner
James E. Bradner Amgen (United States)
Jeremy R. Knowles
Jeremy R. Knowles Harvard University
Andrew C. Kruse
Andrew C. Kruse Harvard University
James J. De Yoreo
James J. De Yoreo Pacific Northwest National Laboratory
Scott B. Ficarro
Scott B. Ficarro Harvard University
Andrew L. Kung
Andrew L. Kung Memorial Sloan Kettering Cancer Center
Elliott Kieff
Elliott Kieff Harvard University

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