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Jeremy R. Knowles

Jeremy R. Knowles

D-Index & Metrics

Chemistry

D-Index
78
Citations
19468
World Ranking
3861
National Ranking
1232

Research.com Recognitions

  • 2003 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1999 - Nakanishi Prize, Chemical Society of Japan and the American Chemical Society.
  • 1995 - Welch Award in Chemistry, Robert A. Welch Foundation
  • 1991 - Davy Medal, Royal Society of London (UK) In recognition of his contributions to mechanistic chemistry integrated with enzymology, particularly the application of chemical methods to solve fundamental biological problems of recognition and catalysis
  • 1988 - Member of the National Academy of Sciences

Overview

Jeremy R. Knowles was affiliated with Harvard University in the United States during their academic career. Their work focused on the intersection of chemistry and enzymology, particularly in the area of mechanistic chemistry applied to biological systems.

Throughout their career, Knowles received several notable awards recognizing their contributions. These included becoming a Fellow of the American Association for the Advancement of Science in 2003 and receiving the Nakanishi Prize from the Chemical Society of Japan and the American Chemical Society in 1999.

Earlier honors included the Welch Award in Chemistry from the Robert A. Welch Foundation in 1995 and the Davy Medal from the Royal Society of London in 1991. The citation for the Davy Medal noted recognition for contributions to mechanistic chemistry integrated with enzymology, especially the use of chemical methods to address fundamental biological problems related to recognition and catalysis.

Knowles was also a member of the National Academy of Sciences, elected in 1988, reflecting their standing in the scientific community.

Their research contributed to fundamental understanding in the field of enzymology and chemical mechanisms, integrating chemical techniques to explore biological catalysis at a detailed level.

Best Publications

  • Enzyme catalysis: not different, just better.

    Jeremy R. Knowles

  • [8] Photoaffinity labeling

    Hagan Bayley;Jeremy R Knowles

  • The Mechanism of Biotin-Dependent Enzymes

    Jeremy R. Knowles

  • Evolution of enzyme function and the development of catalytic efficiency.

    Unknown

  • Perfection in enzyme catalysis: the energetics of triosephosphate isomerase

    Jeremy R. Knowles;W. John Albery

  • Tinkering with enzymes: what are we learning?

    Jeremy R. Knowles

  • Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomerase.

    David L. Pompliano;Anusch Peyman;Jeremy R. Knowles

  • Penicillin resistance: the chemistry of .beta.-lactamase inhibition

    Jeremy R. Knowles

  • Kinetic studies on the inactivation of Escherichia coli RTEM beta-lactamase by clavulanic acid.

    Robert L. Charnas;Jed Fisher;Jeremy R. Knowles

  • beta-Lactamase proceeds via an acyl-enzyme intermediate. Interaction of the Escherichia coli RTEM enzyme with cefoxitin.

    Jed Fisher;Joel G. Belasco;Sundeep Khosla;Jeremy R. Knowles

  • Reduction of aryl azides by thiols: implications for the use of photoaffinity reagents.

    James V. Staros;Hagan Bayley;David N. Standring;Jeremy R. Knowles

  • Searching sequence space by definably random mutagenesis: improving the catalytic potency of an enzyme.

    Jeffrey D. Hermes;Stephen C. Blacklow;Jeremy R. Knowles

  • The conformational equilibrium of chorismate in solution: implications for the mechanism of the non-enzymic and the enzyme-catalyzed rearrangement of chorismate to prephenate

    Shelley D. Copley;Jeremy R. Knowles

  • PROPANE-1,3-DITHIOL: A SELECTIVE REAGENT FOR THE EFFICIENT REDUCTION OF ALKYL AND ARYL AZIDES TO AMINES.

    Hagan Bayley;David N. Standring;Jeremy R. Knowles

  • Triosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by 31P NMR.

    Stephen C. Blacklow;Ronald T. Raines;Wendell A. Lim;Philip D. Zamore

  • Efficiency and evolution of enzyme catalysis.

    W. John Albery;Jeremy R. Knowles

  • Evolutionary optimization of the catalytic effectiveness of an enzyme

    Jonathan J. Burbaum;Ronald T. Raines;W. John Albery;Jeremy R. Knowles

  • Neutral imidazole is the electrophile in the reaction catalyzed by triosephosphate isomerase: structural origins and catalytic implications.

    Patricia J. Lodi;Jeremy R. Knowles

  • A reliable method for random mutagenesis: the generation of mutant libraries using spiked oligodeoxyribonucleotide primers.

    Jeffrey D. Hermes;Shirish M. Parekh;Stephen C. Blacklow;Hubert Koster

  • Secretion of beta-lactamase into the periplasm of Escherichia coli: evidence for a distinct release step associated with a conformational change.

    Abraham Minsky;Richard G. Summers;Jeremy R. Knowles

  • The role of the beta-lactamase signal sequence in the secretion of proteins by Escherichia coli.

    J T Kadonaga;A E Gautier;D R Straus;A D Charles

Frequent Co-Authors

W. John Albery
W. John Albery Imperial College London
Joel G. Belasco
Joel G. Belasco New York University
Stephen C. Blacklow
Stephen C. Blacklow Harvard University
Hagan Bayley
Hagan Bayley University of Oxford
James T. Kadonaga
James T. Kadonaga University of California, San Diego
Gregory A. Petsko
Gregory A. Petsko Cornell University
Gary D. Glick
Gary D. Glick University of Michigan–Ann Arbor
Walter Gilbert
Walter Gilbert Harvard University

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