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Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas

D-Index & Metrics

Molecular Biology

D-Index
96
Citations
47872
World Ranking
602
National Ranking
332

Research.com Recognitions

  • 1996 - Fellow of the American Academy of Arts and Sciences

Overview

Spyros Artavanis-Tsakonas is affiliated with Harvard University in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with additional contributions to medicine. More specifically, the scientist's work involves molecular biology, neurology, pharmacology, and physiology.

The main topics explored in their research include:

  • Amyotrophic Lateral Sclerosis Research
  • Cholinesterase and Neurodegenerative Diseases
  • Bioinformatics and Genomic Networks
  • Alzheimer's Disease Research and Treatments
  • Phosphodiesterase Function and Regulation
  • Microbial Metabolic Engineering and Bioproduction
  • Gene Regulatory Network Analysis

Spyros Artavanis-Tsakonas has contributed to several papers, among them:

  • Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target, 2020, published in Genetics
  • cAMP/PKA signaling regulates TDP-43 aggregation and mislocalization, 2024, published in Proceedings of the National Academy of Sciences
  • Protein domain-based structural interfaces help interpret biologically-relevant interactions in the human interaction network, 2020, published in bioRxiv (Cold Spring Harbor Laboratory)
  • Next-Generation Drosophila Protein Interactome Map and Its Functional Implications, 2023, published in SSRN Electronic Journal
  • Notch: A Signaling Protein That Helps Cells Make Big Decisions, 2025, published in Frontiers for Young Minds

The scientist frequently collaborates with several co-authors, including:

  • Marina Theodorou
  • Diana M. Ho
  • Krishna Praneeth Kilambi
  • Kejie Li
  • Mark W. Kankel

Publication venues where Spyros Artavanis-Tsakonas has appeared include:

  • Genetics
  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • Frontiers for Young Minds

In recognition of their contributions, Spyros Artavanis-Tsakonas was named a Fellow of the American Academy of Arts and Sciences in 1996.

Best Publications

  • Notch Signaling: Cell Fate Control and Signal Integration in Development

    Spyros Artavanis-Tsakonas;Matthew D. Rand;Robert J. Lake

  • Notch signaling : Signal transduction

    S. Artavanis-Tsakonas;K. Matsuno;M. E. Fortini

  • Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

    Kristi A. Wharton;Kristen M. Johansen;Tian Xu;Spyros Artavanis-Tsakonas

  • The BioPlex Network: A Systematic Exploration of the Human Interactome

    Edward L. Huttlin;Lily Ting;Raphael J. Bruckner;Fana Gebreab

  • Architecture of the human interactome defines protein communities and disease networks

    Edward L. Huttlin;Raphael J. Bruckner;Joao A. Paulo;Joe R. Cannon

  • Notch signalling in vertebrate neural development

    Angeliki Louvi;Spyros Artavanis-Tsakonas;Spyros Artavanis-Tsakonas

  • Notch signals control the fate of immature progenitor cells in the intestine

    Silvia Fre;Mathilde Huyghe;Philippos Mourikis;Philippos Mourikis;Sylvie Robine

  • Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

    Ilaria Rebay;Robert J. Fleming;Richard G. Fehon;Lucy Cherbas

  • Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

    Richard G. Fehon;Pamela J. Kooh;Ilaria Rebay;Cathy L. Regan

  • Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

    Christine M Blaumueller;Huilin Qi;Panayiotis Zagouras;Spyros Artavanis-Tsakonas

  • The Notch signalling system: recent insights into the complexity of a conserved pathway.

    K. G. Guruharsha;Mark W. Kankel;Spyros Artavanis-Tsakonas

  • THE SUPPRESSOR OF HAIRLESS PROTEIN PARTICIPATES IN NOTCH RECEPTOR SIGNALING

    Mark E. Fortini;Spyros Artavanis-Tsakonas

  • slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.

    J M Rothberg;J R Jacobs;C S Goodman;S Artavanis-Tsakonas

  • A Protein Complex Network of Drosophila melanogaster

    K.G. Guruharsha;Jean-François Rual;Bo Zhai;Julian Mintseris

  • MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.

    Lizi Wu;Jon C. Aster;Stephen C. Blacklow;Robert Lake

  • Contact-dependent inhibition of cortical neurite growth mediated by notch signaling.

    Nenad Šestan;Spyros Artavanis-Tsakonas;Pasko Rakic

  • Notch signaling at a glance

    Kazuya Hori;Anindya Sen;Spyros Artavanis-Tsakonas

  • Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.

    Ilaria Rebay;Richard G. Fehon;Spyros Artavanis-Tsakonas

  • Calcium depletion dissociates and activates heterodimeric notch receptors.

    Matthew D. Rand;Lisa M. Grimm;Spyros Artavanis-Tsakonas;Vytas Patriub

  • Alterations in Notch signaling in neoplastic lesions of the human cervix

    Panayiotis Zagouras;Stefano Stifani;Christine M. Blaumueller;Maria L. Carcangiu

Frequent Co-Authors

Tian Xu
Tian Xu Westlake University
Angeliki Louvi
Angeliki Louvi Yale University
Richard G. Fehon
Richard G. Fehon University of Chicago
Marc A. T. Muskavitch
Marc A. T. Muskavitch Biogen (United States)
Thomas Walz
Thomas Walz Rockefeller University
Steven P. Gygi
Steven P. Gygi Harvard University
David Van Vactor
David Van Vactor Harvard University
Daniel Louvard
Daniel Louvard Institute Curie
Walter J. Gehring
Walter J. Gehring University of Basel
Susan E. Celniker
Susan E. Celniker Lawrence Berkeley National Laboratory

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