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Microbiology

D-Index
67
Citations
18716
World Ranking
2250
National Ranking
192

Overview

Alasdair P. MacGowan is affiliated with North Bristol NHS Trust in the United Kingdom. Their research spans multiple fields related to medicine, including biochemistry, genetics, and molecular biology, with a particular emphasis on applied microbiology and biotechnology, infectious diseases, pharmacology, and epidemiology.

MacGowan has contributed extensively to the understanding of antimicrobial resistance, antibiotic pharmacokinetics, and the efficacy of antibiotics. Their work also addresses bacterial identification and susceptibility testing, pneumonia and respiratory infections, and clinical research related to COVID-19.

Some of the recent papers authored or co-authored by MacGowan include:

  • Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study, 2023, published in PLoS Medicine
  • Clinical features of 95 sequential hospitalised patients with novel coronavirus 2019 disease (COVID-19), the first UK cohort, 2020, published in Journal of Infection
  • Daptomycin in the treatment of enterococcal bloodstream infections and endocarditis: a EUCAST position paper, 2020, published in Clinical Microbiology and Infection
  • Predicting outcomes of COVID-19 from admission biomarkers: a prospective UK cohort study, 2021, published in Emergency Medicine Journal
  • Clinical and cost effectiveness of single stage compared with two stage revision for hip prosthetic joint infection (INFORM): pragmatic, parallel group, open label, randomised controlled trial, 2022, published in BMJ

Frequent co-authors who have collaborated with MacGowan include:

  • Marie Attwood
  • Fergus Hamilton
  • Alan Noel
  • Karen E. Bowker
  • David Arnold

The main publication venues for their research are:

  • Journal of Antimicrobial Chemotherapy
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical Microbiology and Infection
  • Journal of Infection
  • Medicine

The major fields of study associated with MacGowan's work are:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Subfields within these areas where MacGowan has multiple publications include:

  • Epidemiology
  • Pharmacology
  • Molecular Medicine
  • Infectious Diseases
  • Applied Microbiology and Biotechnology

Key topics in MacGowan's research cover:

  • Antibiotics Pharmacokinetics and Efficacy
  • Antibiotic Resistance in Bacteria
  • Antibiotic Use and Resistance
  • Bacterial Identification and Susceptibility Testing
  • Pneumonia and Respiratory Infections
  • Antimicrobial Resistance in Staphylococcus
  • COVID-19 Clinical Research Studies

Best Publications

  • The global threat of antimicrobial resistance: science for intervention

    Ignasi Roca;Murat Akova;F. Baquero;Jean Carlet

  • Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines

    Kenneth N. Agwuh;Alasdair MacGowan

  • EUCAST expert rules in antimicrobial susceptibility testing

    R. Leclercq;R. Cantón;D.F.J. Brown;C.G. Giske

  • Development of the quinolones.

    Monique I. Andersson;Alasdair P. MacGowan

  • The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria : report from the EUCAST Subcommittee

    M J Ellington;O Ekelund;Frank Møller Aarestrup;R Canton

  • A modified population analysis profile (PAP) method to detect hetero-resistance to vancomycin in Staphylococcus aureus in a UK hospital

    M Wootton;R A Howe;R Hillman;T R Walsh

  • European harmonization of MIC breakpoints for antimicrobial susceptibility testing of bacteria

    Gunnar Kahlmeter;Derek F. J. Brown;Fred W. Goldstein;Alasdair P. MacGowan

  • Evaluation of current methods for detection of staphylococci with reduced susceptibility to glycopeptides.

    Timothy R. Walsh;Anne Bolmström;Anette Qwärnström;Phion Ho

  • Antibiotic treatment of gram-positive bone and joint infections.

    Elizabeth S. R. Darley;Alasdair P. MacGowan

  • Pharmacokinetic and pharmacodynamic profile of linezolid in healthy volunteers and patients with Gram-positive infections

    Alasdair P MacGowan

  • The role of pharmacokinetics/pharmacodynamics in setting clinical MIC breakpoints: the EUCAST approach

    J.W. Mouton;D.F.J. Brown;P. Apfalter;R. Cantón

  • European Committee on Antimicrobial Susceptibility Testing (EUCAST) Technical Notes on antimicrobial susceptibility testing

    G Kahlmeter;Dfj Brown;FW Goldstein;AP MacGowan

  • Establishing MIC breakpoints and the interpretation of in vitro susceptibility tests

    Alasdair P. MacGowan;Richard Wise

  • Conserving antibiotics for the future: New ways to use old and new drugs from a pharmacokinetic and pharmacodynamic perspective

    Johan W Mouton;Paul G Ambrose;Rafael Canton;George L Drusano

  • Vancomycin-resistant Staphylococcus aureus

    Unknown

  • Penetration of linezolid into bone, fat, muscle and haematoma of patients undergoing routine hip replacement

    A. M. Lovering;J. Zhang;G. C. Bannister;B. J. A. Lankester

  • Sequence analysis of the L1 metallo-β-lactamase from Xanthomonas maltophilia

    Timothy R. Walsh;Len Hall;Stephen J. Assinder;Wright W. Nichols

  • The occurrence and seasonal changes in the isolation of Listeria spp. in shop bought food stuffs, human faeces, sewage and soil from urban sources

    Alasdair P. MacGowan;Karen Bowker;James McLauchlin;Peter M. Bennett

  • Antimicrobial susceptibility of the pathogens of bacteraemia in the UK and Ireland 2001–2002: the BSAC Bacteraemia Resistance Surveillance Programme

    Rosy Reynolds;Nicola Potz;Melissa Colman;Andrea Williams

  • Continuous Infusion of β-Lactam Antibiotics

    Alasdair P. MacGowan;Karen E. Bowker

  • Sequence analysis and enzyme kinetics of the L2 serine beta-lactamase from Stenotrophomonas maltophilia.

    T R Walsh;A P MacGowan;P M Bennett

  • Why monitor peak vancomycin concentrations?

    Unknown

Frequent Co-Authors

Timothy R. Walsh
Timothy R. Walsh University of Oxford
Peter M. Bennett
Peter M. Bennett University of Bristol
Jonathan A C Sterne
Jonathan A C Sterne University of Bristol
Paul Little
Paul Little University of Southampton
Michael T. Lawton
Michael T. Lawton Barrow Neurological Institute
Leonard Leibovici
Leonard Leibovici Tel Aviv University
Gunnar Kahlmeter
Gunnar Kahlmeter Uppsala University
Christian G. Giske
Christian G. Giske Karolinska University Hospital
Rafael Cantón
Rafael Cantón Instituto Ramón y Cajal de Investigación Sanitaria
Johan W. Mouton
Johan W. Mouton Radboud University Medical Center

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