Junichi Azuma

Best Publications

• Treatment of rheumatoid arthritis with humanized anti–interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial

  Norihiro Nishimoto;Kazuyuki Yoshizaki;Nobuyuki Miyasaka;Kazuhiko Yamamoto

  1177
  Citations

• A pilot randomized Trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease

  Hiroaki Ito;Masakazu Takazoe;Yoshihiro Fukuda;Toshifumi Hibi

  952
  Citations

• Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production

  Chian Ju Jong;Junichi Azuma;Stephen Schaffer

  500
  Citations

• Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy

  Norihiro Nishimoto;Nobuyuki Miyasaka;Kazuhiko Yamamoto;Shinichi Kawai

  497
  Citations

• Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study

  Norihiro Nishimoto;Nobuyuki Miyasaka;Kazuhiko Yamamoto;Shinichi Kawai

  451
  Citations

• Hypoxic stress induces cardiac myocyte-derived interleukin-6

  Keiko Yamauchi-Takihara;Yoshiji Ihara;Atsushi Ogata;Kazuyuki Yoshizaki

  423
  Citations

• Physiological roles of taurine in heart and muscle

  Stephen W Schaffer;Chian Ju Jong;Ramila Kc;Junichi Azuma

  395
  Citations

• Role of antioxidant activity of taurine in diabetes.

  Stephen W. SchafferS.W. Schaffer;Stephen W. SchafferS.W. Schaffer;Stephen W. SchafferS.W. Schaffer;Junichi AzumaJ. Azuma;Junichi AzumaJ. Azuma;Junichi AzumaJ. Azuma;Mahmood MozaffariM. Mozaffari;Mahmood MozaffariM. Mozaffari;Mahmood MozaffariM. Mozaffari

  389
  Citations

• Role of osmoregulation in the actions of taurine.

  S Schaffer;K Takahashi;J Azuma

  349
  Citations

• Pharmacokinetics/genotype associations for major cytochrome P450 enzymes in native and first- and third-generation Japanese populations: comparison with Korean, Chinese, and Caucasian populations.

  SP Myrand;K Sekiguchi;MZ Man;X Lin

  296
  Citations

• NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: A randomized controlled trial for pharmacogenetics-based therapy

  Junichi Azuma;Masako Ohno;Masako Ohno;Ryuji Kubota;Soichiro Yokota

  282
  Citations

• Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy

  Takashi Ito;Yasushi Kimura;Yoriko Uozumi;Mika Takai

  270
  Citations

• Analysis of Functional Group Sited on Multi-Wall Carbon Nanotube Surface

  Rike Yudianti;Holia Onggo;Sudirman;Yukie Saito

  245
  Citations

• The potential usefulness of taurine on diabetes mellitus and its complications.

  Takashi Ito;Stephen W. Schaffer;Junichi Azuma

  237
  Citations

• Therapeutic Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-11 Ameliorates Cardiac Fibrosis After Myocardial Infarction

  Masanori Obana;Makiko Maeda;Koji Takeda;Akiko Hayama

  228
  Citations

• STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart

  Yuichi Oshima;Yasushi Fujio;Tsuyoshi Nakanishi;Norio Itoh

  207
  Citations

• Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients.

  Masaki Kato;Tsuyoshi Fukuda;Masataka Wakeno;Kazuhiro Fukuda

  201
  Citations

• Why is taurine cytoprotective

  Stephen Schaffer;Junichi Azuma;Kyoko Takahashi;Mahmood S Mozaffari

  199
  Citations

• Usefulness of taurine in chronic congestive heart failure and its prospective application.

  Junichi Azuma;Akihiko Sawamura;Nobuhisa Awata

  193
  Citations

• Taurine inhibits apoptosis by preventing formation of the Apaf-1/caspase-9 apoptosome

  Tomoka Takatani;Kyoko Takahashi;Yoriko Uozumi;Eriko Shikata

  185
  Citations