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Molecular Biology

D-Index
78
Citations
24313
World Ranking
1071
National Ranking
558

Overview

Thomas Gridley is a researcher affiliated with the University of Maine in the United States. Their work primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with additional contributions to Medicine. Their expertise covers several subfields such as Molecular Biology, Genetics, Developmental Neuroscience, Surgery, and Immunology and Allergy.

The scientist's research has focused on topics including Neurogenesis and neuroplasticity mechanisms, Developmental Biology and Gene Regulation, Epigenetics and DNA Methylation, Cell Adhesion Molecules Research, Ubiquitin and proteasome pathways, RNA Research and Splicing, and Thyroid Disorders and Treatments.

Recent publications by Thomas Gridley include:

  • Mouse mutagenesis and phenotyping to generate models of development and disease, 2022, published in Current Topics in Developmental Biology
  • DIO3 protects against thyrotoxicosis-derived cranio-encephalic and cardiac congenital abnormalities, 2022, published in JCI Insight
  • Notch1 and Notch2 collaboratively maintain radial glial cells in mouse neurogenesis, 2020, published in Neuroscience Research
  • Stromal SNAI2 Is Required for ERBB2 Breast Cancer Progression, 2020, published in Cancer Research
  • Notch Dosage: Jagged1 Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice, 2020, published in Frontiers in Cell and Developmental Biology

Thomas Gridley frequently publishes in venues such as:

  • Current Topics in Developmental Biology
  • Neuroscience Research
  • Cancer Research
  • JCI Insight
  • Frontiers in Cell and Developmental Biology

The scientist has collaborated often with several coauthors, including Ilka Pinz, Shun Mase, Atsunori Shitamukai, Quan Wu, and Mitsuru Morimoto.

Best Publications

  • Notch signaling is essential for vascular morphogenesis in mice.

    Luke T. Krebs;Yingzi Xue;Christine R. Norton;John R. Shutter

  • Embryonic Lethality and Vascular Defects in Mice Lacking the Notch Ligand Jagged1

    Yingzi Xue;Xiang Gao;Claire E. Lindsell;Christine R. Norton

  • The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition.

    Ethan A. Carver;Rulang Jiang;Yu Lan;Kathleen F. Oram

  • Roles for Nkx3.1 in prostate development and cancer

    Rajula Bhatia-Gaur;Annemarie A. Donjacour;Peter J. Sciavolino;Peter J. Sciavolino;Minjung Kim;Minjung Kim

  • Notch signalling pathway mediates hair cell development in mammalian cochlea.

    Pamela J. Lanford;Yu Lan;Rulang Jiang;Claire Lindsell

  • Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

    Luke T. Krebs;John R. Shutter;Kenji Tanigaki;Tasuku Honjo

  • A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency.

    Brent McCright;Julie Lozier;Thomas Gridley

  • Notch3 is required for arterial identity and maturation of vascular smooth muscle cells

    Valérie Domenga;Peggy Fardoux;Pierre Lacombe;Marie Monet

  • Defects in somite formation in lunatic fringe -deficient mice

    Nian Zhang;Thomas Gridley

  • Notch signaling in vascular development and physiology

    Thomas Gridley

  • Direct Regulation of Gata3 Expression Determines the T Helper Differentiation Potential of Notch

    Derk Amsen;Andrey Antov;Dragana Jankovic;Alan Sher

  • Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

    Rulang Jiang;Yu Lan;Harry D. Chapman;Carrie Shawber

  • Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation.

    Brent McCright;Xiang Gao;Liya Shen;Julie Lozier

  • Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer.

    Verónica Rodilla;Alberto Villanueva;Antonia Obrador-Hevia;Àlex Robert-Moreno

  • gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis.

    Yonghua Pan;Meei-Hua Lin;Xiaolin Tian;Hui-Teng Cheng

  • Notch signaling and inherited disease syndromes

    Thomas Gridley

  • The slug gene is not essential for mesoderm or neural crest development in mice

    Rulang Jiang;Yu Lan;Christine R. Norton;John P. Sundberg

  • Notch signaling in the vasculature.

    Thomas Gridley

  • Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes.

    Pierre Savagner;Donna Frances Kusewitt;Ethan A. Carver;Fabrice Magnino

  • The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear.

    Amy E Kiernan;Jingxia Xu;Thomas Gridley

Frequent Co-Authors

Rulang Jiang
Rulang Jiang Cincinnati Children's Hospital Medical Center
Yu Lan
Yu Lan Cincinnati Children's Hospital Medical Center
Freddy Radtke
Freddy Radtke École Polytechnique Fédérale de Lausanne
Lucy Liaw
Lucy Liaw Maine Medical Center
Calvin P.H. Vary
Calvin P.H. Vary Maine Medical Center
Raphael Kopan
Raphael Kopan Cincinnati Children's Hospital Medical Center
Gerry Weinmaster
Gerry Weinmaster University of California, Los Angeles
Debra J. Gilbert
Debra J. Gilbert National Institutes of Health
Neal G. Copeland
Neal G. Copeland The University of Texas MD Anderson Cancer Center
Nancy A. Jenkins
Nancy A. Jenkins The University of Texas MD Anderson Cancer Center

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