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D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
18662
World Ranking
6622
National Ranking
3082

Overview

Scott B. Ficarro is affiliated with Harvard University in the United States. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology and Oncology, alongside contributions to Spectroscopy, Organic Chemistry, and Immunology.

The scientist's primary research topics include Peptidase Inhibition and Analysis, Ubiquitin and proteasome pathways, Protein Degradation and Inhibitors, Click Chemistry and Applications, Advanced Proteomics Techniques and Applications, Mass Spectrometry Techniques and Applications, and Hippo pathway signaling and YAP/TAZ.

Notable recent publications authored or co-authored by Scott B. Ficarro are:

  • Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway (2020, Cancer Cell)
  • Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo (2021, Nature Chemical Biology)
  • Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism (2020, Scientific Reports)
  • Development of a covalent inhibitor of gut bacterial bile salt hydrolases (2020, Nature Chemical Biology)
  • Epitope editing enables targeted immunotherapy of acute myeloid leukaemia (2023, Nature)

Frequent collaborators in the scientist's work include Jarrod A. Marto, Nathanael S. Gray, Tinghu Zhang, Sirano Dhe-Paganon, and Hyuk-Soo Seo.

The main venues for the scientist's publications include bioRxiv (Cold Spring Harbor Laboratory), Journal of Medicinal Chemistry, Nature Chemical Biology, ACS Medicinal Chemistry Letters, and Nature Communications.

Best Publications

  • Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae

    Scott B Ficarro;Mark L McCleland;P Todd Stukenberg;Daniel J Burke

  • Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

    Nicholas Kwiatkowski;Tinghu Zhang;Peter B. Rahl;Brian J Abraham

  • Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation.

    Scott Ficarro;Olga Chertihin;V. Anne Westbrook;Forest White

  • Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma.

    Pilar Caro;Amar U. Kishan;Amar U. Kishan;Erik Norberg;Illana A. Stanley

  • Androgen Receptor Phosphorylation REGULATION AND IDENTIFICATION OF THE PHOSPHORYLATION SITES

    Daniel Gioeli;Scott B. Ficarro;Jesse J. Kwiek;David Aaronson

  • Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

    Orit Rozenblatt-Rosen;Rahul C Deo;Rahul C Deo;Megha Padi;Guillaume Adelmant

  • Exploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain.

    Nelly Khidekel;Scott B. Ficarro;Eric C. Peters;Linda C. Hsieh-Wilson

  • Probing the dynamics of O -GlcNAc glycosylation in the brain using quantitative proteomics

    Nelly Khidekel;Scott B Ficarro;Peter M Clark;Marian C Bryan

  • Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

    Arthur R. Salomon;Scott B. Ficarro;Laurence M. Brill;Achim Brinker

  • Discovery of Potent and Selective Covalent Inhibitors of JNK

    Tinghu Zhang;Francisco Inesta-Vaquera;Mario Niepel;Jianming Zhang

  • Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway.

    Kari J. Kurppa;Yao Liu;Ciric To;Tinghu Zhang

  • Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor†

    Sang Min Lim;Kenneth D. Westover;Scott B. Ficarro;Rane A. Harrison

  • LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.

    Jin Zhang;Sutheera Ratanasirintrawoot;Sutheera Ratanasirintrawoot;Sriram Chandrasekaran;Zhaoting Wu

  • Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

    Tinghu Zhang;Nicholas Kwiatkowski;Nicholas Kwiatkowski;Calla M Olson;Sarah E Dixon-Clarke

  • Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

    Edward C. Twomey;Zhejian Ji;Thomas E. Wales;Nicholas O. Bodnar

  • Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

    Laurence M Brill;Arthur R Salomon;Scott B Ficarro;Mridul Mukherji

  • Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.

    Eunyoung Park;Shaun Rawson;Kunhua Li;Byeong-Won Kim

  • cAMP-dependent tyrosine phosphorylation of subunit I inhibits cytochrome c oxidase activity.

    Icksoo Lee;Arthur R. Salomon;Scott Ficarro;Isabella Mathes

  • In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.

    John C. Hunter;Deepak Gurbani;Scott B. Ficarro;Martin A. Carrasco

  • Phosphorylated peptides are naturally processed and presented by major histocompatibility complex class I molecules in vivo.

    Angela L. Zarling;Scott B. Ficarro;Forest M. White;Jeffrey Shabanowitz

Frequent Co-Authors

Jarrod A. Marto
Jarrod A. Marto Harvard University
Nathanael S. Gray
Nathanael S. Gray Stanford University
Tinghu Zhang
Tinghu Zhang Stanford University
Eric C. Peters
Eric C. Peters Genomics Institute of the Novartis Research Foundation
Sirano Dhe-Paganon
Sirano Dhe-Paganon Harvard University
Stephen Buratowski
Stephen Buratowski Harvard University
Donald F. Hunt
Donald F. Hunt University of Virginia
Michael J. Eck
Michael J. Eck Harvard University
Rameen Beroukhim
Rameen Beroukhim Harvard University

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