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Michael J. Eck

D-Index & Metrics

Biology and Biochemistry

D-Index
94
Citations
58846
World Ranking
1954
National Ranking
1070

Michael J. Eck publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Michael J. Eck sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 280 publications — 74th percentile

74% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Michael J. Eck D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Michael J. Eck sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 94 D-Index — 90th percentile

90% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Michael J. Eck is affiliated with Harvard University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a total of 88 publications in the former and 52 in the latter. The scientist's work further narrows into key subfields such as Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, Organic Chemistry, and Cell Biology.

Their research topics focus predominantly on lung cancer treatments and mutations, cancer therapeutics and mechanisms, melanoma and MAPK pathways, HER2/EGFR in cancer research, protein kinase regulation and GTPase signaling, protein degradation and inhibitors, as well as quinazolinone synthesis and applications.

Frequent co-authors in their publications include Tyler S. Beyett with 23 collaborations, David E. Heppner with 17, Pasi A. Jänne with 14, Hyesung Jeon with 13, and Eunyoung Park with 12.

The scientist has published regularly in venues such as bioRxiv (Cold Spring Harbor Laboratory) with 7 papers, Nature Communications with 6, Journal of Medicinal Chemistry with 5, Journal of Biological Chemistry with 3, and Neuro-Oncology with 3 publications.

Examples of recent papers include:

  • An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer, 2022, Nature Cancer
  • Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations, 2020, Angewandte Chemie International Edition
  • Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors, 2022, Nature Communications
  • Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation, 2021, Proceedings of the National Academy of Sciences
  • Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors, 2020, Journal of Medicinal Chemistry

Best Publications

  • EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

    J. Guillermo Paez;Pasi A. Jänne;Pasi A. Jänne;Jeffrey C. Lee;Sean Tracy

  • EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

    Susumu Kobayashi;Titus J. Boggon;Tajhal Dayaram;Pasi A. Jänne

  • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.

    Ross L. Levine;Ross L. Levine;Martha Wadleigh;Jan Cools;Benjamin L. Ebert;Benjamin L. Ebert

  • The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

    Cai-Hong Yun;Kristen E. Mengwasser;Angela V. Toms;Michele S. Woo

  • Three-dimensional structure of the tyrosine kinase c-Src

    Wenqing Xu;Stephen C. Harrison;Michael J. Eck

  • Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

    Wenjun Zhou;Dalia Ercan;Liang Chen;Cai-Hong Yun

  • Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity

    Cai-Hong Yun;Titus J. Boggon;Yiqun Li;Michele S. Woo

  • Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

    Zhou Songyang;Zhou Songyang;Kermit L. Carraway;Michael J. Eck;Stephen C. Harrison

  • Crystal Structure of the Tyrosine Phosphatase SHP-2

    Peter Hof;Scott Pluskey;Sirano Dhe-Paganon;Michael J Eck

  • Crystal structures of c-Src reveal features of its autoinhibitory mechanism.

    Wenqing Xu;Amish Doshi;Ming Lei;Michael J Eck

  • Mechanism and Function of Formins in the Control of Actin Assembly

    Bruce L. Goode;Michael J. Eck

  • Structure and regulation of Src family kinases.

    Titus J Boggon;Michael J Eck

  • The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.

    M J Eck;S R Sprang

  • Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

    Yong Jia;Cai-Hong Yun;Eunyoung Park;Dalia Ercan

  • Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

    Michael J. Eck;Steven E. Shoelson;Stephen C. Harrison;Stephen C. Harrison

  • A Novel ALK Secondary Mutation and EGFR Signaling Cause Resistance to ALK Kinase Inhibitors

    Takaaki Sasaki;Jussi Koivunen;Atsuko Ogino;Masahiko Yanagita

  • Structure of PAK1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch

    Ming Lei;Wange Lu;Wuyi Meng;Maria-Carla Parrini

  • Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.

    Andrew L. Kung;Sonya D. Zabludoff;Sonya D. Zabludoff;Steven J. Freedman;Steven J. Freedman

  • Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.

    Steven J. Freedman;Zhen-Yu J. Sun;Florence Poy;Andrew L. Kung

  • Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

    Peter S. Hammerman;Martin L. Sos;Alex H. Ramos;Chunxiao Xu

Frequent Co-Authors

Pasi A. Jänne
Pasi A. Jänne Harvard University
Matthew Meyerson
Matthew Meyerson Harvard University
Nathanael S. Gray
Nathanael S. Gray Stanford University
Heidi Greulich
Heidi Greulich Broad Institute
Kwok-Kin Wong
Kwok-Kin Wong New York University
Stephen C. Harrison
Stephen C. Harrison Harvard University
Titus J. Boggon
Titus J. Boggon Yale University
Steven E. Shoelson
Steven E. Shoelson Harvard University
Jarrod A. Marto
Jarrod A. Marto Harvard University
Scott B. Ficarro
Scott B. Ficarro Harvard University

External Links

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Best Scientists Citing Michael J. Eck

Pasi A. Jänne

Pasi A. Jänne

Harvard University

Publications: 211

Matthew Meyerson

Matthew Meyerson

Harvard University

Publications: 140

William Pao

William Pao

Roche (United States)

Publications: 124

Ross L. Levine

Ross L. Levine

Memorial Sloan Kettering Cancer Center

Publications: 113

Tetsuya Mitsudomi

Tetsuya Mitsudomi

Kindai University

Publications: 110

Nathanael S. Gray

Nathanael S. Gray

Stanford University

Publications: 106

Srdan Verstovsek

Srdan Verstovsek

The University of Texas MD Anderson Cancer Center

Publications: 104

Mark G. Kris

Mark G. Kris

Memorial Sloan Kettering Cancer Center

Publications: 99

Kwok-Kin Wong

Kwok-Kin Wong

New York University

Publications: 98

Ayalew Tefferi

Ayalew Tefferi

Mayo Clinic

Publications: 94

Vincent A. Miller

Vincent A. Miller

EQRx

Publications: 93

Tony Pawson

Tony Pawson

University of Toronto

Publications: 92

Gregory J. Riely

Gregory J. Riely

Memorial Sloan Kettering Cancer Center

Publications: 87

John Kuriyan

John Kuriyan

Vanderbilt University

Publications: 86

Jeffrey A. Engelman

Jeffrey A. Engelman

Novartis Institutes for BioMedical Research (NIBR)

Publications: 86

Stefan N. Constantinescu

Stefan N. Constantinescu

Ludwig Cancer Research

Publications: 85

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