What is he best known for?
The fields of study he is best known for:
Darrel W. Stafford mainly focuses on Biochemistry, Factor IX, Molecular biology, Vitamin K epoxide reductase and Gamma-glutamyl carboxylase.
Enzyme, Alanine, Peptide sequence, Peptide and Integral membrane protein are among the areas of Biochemistry where the researcher is concentrating his efforts.
His Factor IX study incorporates themes from Recombinant DNA, Immunology, Genetic enhancement, Gene targeting and Binding site.
His Molecular biology study integrates concerns from other disciplines, such as Complementary DNA, Molecular mass, Factor X and Ultracentrifuge.
His Vitamin K epoxide reductase research incorporates themes from Vitamin K Epoxide Reductase Complex Subunit 1 and VKORC1.
The study incorporates disciplines such as Missense mutation, Genetics, Mutation, Point mutation and Allele in addition to Pyruvate carboxylase.
His most cited work include:
- A general method for isolation of high molecular weight DNA from eukaryotes (2314 citations)
- Identification of the gene for vitamin K epoxide reductase (623 citations)
- Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors (411 citations)
What are the main themes of his work throughout his whole career to date?
His main research concerns Biochemistry, Factor IX, Molecular biology, Vitamin K epoxide reductase and Pyruvate carboxylase.
In his study, he carries out multidisciplinary Biochemistry and Gamma-glutamyl carboxylase research.
His Factor IX research is multidisciplinary, incorporating elements of Gla domain, Factor VII, Coagulation, Genetic enhancement and Antibody.
His Molecular biology study combines topics in areas such as Complementary DNA, Mutant, Gene, Recombinant DNA and Lytechinus variegatus.
He works mostly in the field of Pyruvate carboxylase, limiting it down to topics relating to Transmembrane domain and, in certain cases, Endoplasmic reticulum.
His work deals with themes such as Peptide sequence and Peptide, which intersect with Protein precursor.
He most often published in these fields:
- Biochemistry (52.30%)
- Factor IX (30.46%)
- Molecular biology (28.16%)
What were the highlights of his more recent work (between 2011-2021)?
- Biochemistry (52.30%)
- Vitamin K epoxide reductase (20.69%)
- Factor IX (30.46%)
In recent papers he was focusing on the following fields of study:
The scientist’s investigation covers issues in Biochemistry, Vitamin K epoxide reductase, Factor IX, Vitamin and Enzyme.
His Biochemistry research includes elements of Vitamin k and Function.
Darrel W. Stafford combines subjects such as Missense mutation, Blood coagulation factors, Molecular biology and Glutamyl carboxylase with his study of Vitamin k.
His Factor IX research integrates issues from Hemostasis, Surgery, Gla domain, Wild type and Bone remodeling.
The various areas that he examines in his Vitamin study include Anticoagulant, Drug resistance and Antithrombotic.
His Enzyme research includes elements of Gamma-glutamyl carboxylase and Warfarin resistance.
Between 2011 and 2021, his most popular works were:
- Employing a Gain-of-Function Factor IX Variant R338L to Advance the Efficacy and Safety of Hemophilia B Human Gene Therapy: Preclinical Evaluation Supporting an Ongoing Adeno-Associated Virus Clinical Trial (79 citations)
- Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells. (50 citations)
- Structural and functional insights into enzymes of the vitamin K cycle. (43 citations)
In his most recent research, the most cited papers focused on:
Biochemistry, Vitamin K epoxide reductase, Factor IX, Enzyme and Vitamin are his primary areas of study.
His study in Integral membrane protein, Nanodisc, Effector and Protein carboxylation falls within the category of Biochemistry.
His work carried out in the field of Factor IX brings together such families of science as Hemostasis, Surgery, Endocrinology and Mechanism of action.
His Endocrinology study combines topics from a wide range of disciplines, such as Phenotype, Factor VII, Mutant and Gla domain.
His work on NAD+ kinase, Quinone oxidoreductase and Active site as part of general Enzyme research is often related to Gamma-glutamyl carboxylase, thus linking different fields of science.
His biological study spans a wide range of topics, including Mutation, Bleeding diathesis and Coagulation.
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