World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
15475
World Ranking
11816
National Ranking
5082

Overview

Darrel W. Stafford is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research spans multiple key fields, primarily focusing on Biochemistry, Genetics and Molecular Biology, Medicine, and Nursing. These areas encompass a broad interdisciplinary approach to studying molecular mechanisms and clinical applications.

The scientist's work is concentrated in specific subfields such as Nutrition and Dietetics, Molecular Biology, Hematology, Cell Biology, and Genetics. These subfields represent the technical and thematic foundations underpinning their research output.

The main topics addressed by their research include:

  • Vitamin K Research Studies
  • Biotin and Related Studies
  • Hemophilia Treatment and Research
  • Hormonal Regulation and Hypertension
  • Enzyme function and inhibition
  • Platelet Disorders and Treatments
  • Pharmacogenetics and Drug Metabolism

Throughout their career, Darrel W. Stafford has contributed to academic literature published in several venues, with their most frequent publication platforms being:

  • UNC Libraries
  • Blood
  • Haemophilia
  • Journal of Thrombosis and Haemostasis
  • OPAL (Open@LaTrobe) (La Trobe University)

Selected recent publications illustrating their research include:

  • A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase, 2023, Nature Communications
  • γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K-dependent proteins, 2020, Blood
  • The Function of extravascular coagulation factor IX in haemostasis, 2021, Haemophilia
  • International consensus recommendations on the management of people with haemophilia B, 2022, Therapeutic Advances in Hematology
  • A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase, 2020, Journal of Thrombosis and Haemostasis

The scientist collaborates regularly with several frequent co-authors, reflecting a collaborative approach to their research field. These include:

  • Jian-Ke Tie
  • Da-Yun Jin
  • Xuejie Chen
  • David L. Straight
  • Da Yun Jin

Best Publications

  • A general method for isolation of high molecular weight DNA from eukaryotes

    Nikolaus Blin;Darrel W. Stafford

  • Identification of the gene for vitamin K epoxide reductase

    Tao Li;Chun Yun Chang;Da Yun Jin;Pen Jen Lin

  • Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors

    Richard O. Snyder;Carol Miao;Leonard Meuse;Julie Tubb

  • The vitamin K cycle

    D. W. Stafford

  • A Coagulation Factor IX-Deficient Mouse Model for Human Hemophilia B

    Hui Feng Lin;Nobuyo Maeda;Oliver Smithies;David L. Straight

  • Cloning and expression of the cDNA for human γ-glutamyl carboxylase

    Sheue Mei Wu;Wing Fai Cheung;Dan Frazier;Darrel W. Stafford

  • Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family.

    Neil F. Rebbe;Jerry Ware;Rogier M. Bertina;Paul Modrich

  • Nucleotide Sequence and Deduced Primary Structure of Cellobiohydrolase II from Trichoderma Reesei

    Chung Mong Chen;Mikelina Gritzali;Darrel W. Stafford

  • A Missense Mutation in γ-Glutamyl Carboxylase Gene Causes Combined Deficiency of All Vitamin K-Dependent Blood Coagulation Factors

    Benjamin Brenner;Beatriz Sánchez-Vega;Beatriz Sánchez-Vega;Sheue Mei Wu;Sheue Mei Wu;Naomi Lanir;Naomi Lanir

  • Conformational analysis of membrane proteins in phospholipid bilayer nanodiscs by hydrogen exchange mass spectrometry.

    Christine M. Hebling;Christopher R. Morgan;Darrel W. Stafford;James W. Jorgenson

  • Human Factor IX Corrects the Bleeding Diathesis of Mice With Hemophilia B

    Szu Hao Kung;J. N. Hagstrom;Darrell Cass;Shing Jen Tai

  • The Propeptides of the Vitamin K-dependent Proteins Possess Different Affinities for the Vitamin K-dependent Carboxylase

    Thomas B. Stanley;Da Yun Jin;Pen Jen Lin;Darrel W Stafford

  • Membrane Topology Mapping of Vitamin K Epoxide Reductase by in Vitro Translation/Cotranslocation

    Jian-Ke Tie;Christopher V. Nicchitta;Gunnar von Heijne;Darrel W. Stafford

  • Employing a Gain-of-Function Factor IX Variant R338L to Advance the Efficacy and Safety of Hemophilia B Human Gene Therapy: Preclinical Evaluation Supporting an Ongoing Adeno-Associated Virus Clinical Trial

    Paul E Monahan;Junjiang Sun;Tong Gui;Genlin Hu

  • Enhanced gamma-carboxylation of recombinant factor X using a chimeric construct containing the prothrombin propeptide.

    Rodney M. Camire;Peter J. Larson;Darrel W. Stafford;Katherine A. High

  • Changing Residue 338 in Human Factor IX from Arginine to Alanine Causes an Increase in Catalytic Activity

    Jinli Chang;Jianping Jin;Pete Lollar;Wolfram Bode

  • A mutation in the propeptide of Factor IX leads to warfarin sensitivity by a novel mechanism.

    Kirk Chu;Sheue Mei Wu;Tom Stanley;Darrel W. Stafford

  • Processive Post-translational Modification VITAMIN K-DEPENDENT CARBOXYLATION OF A PEPTIDE SUBSTRATE

    Daniel P. Morris;Robert D. Stevens;David J. Wright;Darrel W. Stafford

  • Evidence for a prevalent dimorphism in the activation peptide of human coagulation factor IX.

    R A McGraw;L M Davis;C M Noyes;R L Lundblad

  • Identification and purification to near homogeneity of the vitamin K-dependent carboxylase.

    Sheue Mei Wu;Daniel P. Morris;Darrel W. Stafford

Frequent Co-Authors

Lee G. Pedersen
Lee G. Pedersen University of North Carolina at Chapel Hill
Katherine A. High
Katherine A. High Children's Hospital of Philadelphia
Cees Vermeer
Cees Vermeer Maastricht University
Jerry Ware
Jerry Ware University of Arkansas for Medical Sciences
Dougald M. Monroe
Dougald M. Monroe University of North Carolina at Chapel Hill
Heyu Ni
Heyu Ni University of Toronto
James W. Jorgenson
James W. Jorgenson University of North Carolina at Chapel Hill
Lalith Perera
Lalith Perera National Institutes of Health
John R. Engen
John R. Engen Northeastern University
Yoshihide Kanaoka
Yoshihide Kanaoka Brigham and Women's Hospital

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