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Immunology

D-Index
63
Citations
11468
World Ranking
3071
National Ranking
71

Overview

Heyu Ni is affiliated with the University of Toronto in Canada and has contributed extensively to the field of medicine, focusing primarily on hematology. Their research spans multiple subfields including molecular biology, surgery, immunology, and genetics.

Ni's work encompasses key topics such as platelet disorders and treatments, blood coagulation and thrombosis mechanisms, antiplatelet therapy related to cardiovascular diseases, cell adhesion molecules research, blood groups and transfusion, venous thromboembolism diagnosis and management, and the properties of blood and coagulation.

The scientist has published papers in multiple venues, with frequent contributions to:

  • Blood
  • Journal of Thrombosis and Haemostasis
  • Research and Practice in Thrombosis and Haemostasis
  • SSRN Electronic Journal
  • Journal of Thoracic Oncology

Among recent papers, the following are notable:

  • "Crosstalk Between Platelets and Microbial Pathogens" (2020) published in Frontiers in Immunology
  • "Hypoxia and low temperature upregulate transferrin to induce hypercoagulability at high altitude" (2022) published in Blood
  • "The 14-3-3ζ-c-Src-integrin-β3 complex is vital for platelet activation" (2020) published in Blood
  • "In vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbα" (2021) published in Scientific Reports
  • "Novel contact-kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke" (2022) published in Cellular and Molecular Life Sciences

Heyu Ni frequently collaborates with a number of researchers, including:

  • Chuanbin Shen
  • Daniel Thomas MacKeigan
  • Danielle Karakas
  • Xi Lei
  • Miguel A. D. Neves

Best Publications

  • Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-α production in vivo

    Rukhsana Aslam;Edwin R. Speck;Michael Kim;Andrew R. Crow

  • Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

    Heyu Ni;Cécile V. Denis;Sangeetha Subbarao;Jay L. Degen

  • Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia

    June Li;Dianne E. van der Wal;Guangheng Zhu;Miao Xu

  • Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond

    Xiaohong Ruby Xu;Dan Zhang;Brigitta Elaine Oswald;Naadiya Carrim

  • Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents.

    Xiaohong Ruby Xu;Xiaohong Ruby Xu;Xiaohong Ruby Xu;George M. Yousef;George M. Yousef;Heyu Ni

  • Plasma fibronectin promotes thrombus growth and stability in injured arterioles

    Heyu Ni;Peter S. T. Yuen;Jessie M. Papalia;Jane E. Trevithick

  • N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice

    Junmei Chen;Adili Reheman;Francisca C. Gushiken;Leticia Nolasco

  • A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell–mediated responses that are differentially sensitive to therapy

    Leola Chow;Leola Chow;Rukhsana Aslam;Rukhsana Aslam;Edwin R. Speck;Edwin R. Speck;Michael Kim

  • Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPARα

    Sanjeev Sethi;Ouliana Ziouzenkova;Heyu Ni;Denisa D. Wagner

  • Platelets in hemostasis and thrombosis: role of integrins and their ligands.

    Heyu Ni;John Freedman

  • Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis.

    Yan Hou;Naadiya Carrim;Naadiya Carrim;Naadiya Carrim;Yiming Wang;Yiming Wang;Yiming Wang;Reid C. Gallant;Reid C. Gallant

  • Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis

    Andrew J Murphy;Nora Bijl;Laurent Yvan-Charvet;Carrie B Welch

  • Plasma fibronectin supports hemostasis and regulates thrombosis

    Yiming Wang;Adili Reheman;Christopher M. Spring;Jalil Kalantari

  • Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies.

    Xiaohong Ruby Xu;Naadiya Carrim;Miguel Antonio Dias Neves;Thomas McKeown

  • Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by antiplatelet GPIIbIIIa versus GPIbα antibodies

    Michelle Lee Webster;Ebrahim Sayeh;Min Crow;Pingguo Chen

  • Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries

    Conglei Li;June Li;Yan-Yan Li;Yan-Yan Li;Sean Lang;Sean Lang

  • Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin α-chain crosslinking

    James R. Byrnes;Cédric Duval;Yiming Wang;Caroline E. Hansen;Caroline E. Hansen

  • Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis

    Xi Lei;Adili Reheman;Yan Hou;Hui Zhou

  • Association of autoantibody specificity and response to intravenous immunoglobulin G therapy in immune thrombocytopenia: a multicenter cohort study

    J. Peng;S.-H. Ma;J. Liu;Y. Hou

  • Integrin Activation by Dithiothreitol or Mn2+ Induces a Ligand-occupied Conformation and Exposure of a Novel NH2-terminal Regulatory Site on the β1Integrin Chain

    Heyu Ni;Anli Li;Neil Simonsen;John A. Wilkins

Frequent Co-Authors

John Freedman
John Freedman University of Toronto
John W. Semple
John W. Semple Lund University
Hong Yang
Hong Yang University of Illinois at Urbana-Champaign
Denisa D. Wagner
Denisa D. Wagner Boston Children's Hospital
Zaverio M. Ruggeri
Zaverio M. Ruggeri Scripps Research Institute
Jane E. Freedman
Jane E. Freedman Vanderbilt University Medical Center
Cheng Zhu
Cheng Zhu Georgia Institute of Technology
Jerry Ware
Jerry Ware University of Arkansas for Medical Sciences
Patrick Tso
Patrick Tso University of Cincinnati

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