Valder R. Arruda

Overview

Best Publications

• Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

  Albert M. Maguire;Francesca Simonelli;Eric A. Pierce;Edward N. Pugh

  2593
  Citations

• Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

  Manno Cs;Pierce Gf;Arruda Vr;Glader B

  2495
  Citations

• Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector

  Mark A. Kay;Catherine S. Manno;Catherine S. Manno;Margaret V. Ragni;Peter J. Larson;Peter J. Larson

  1325
  Citations

• Geographic Distribution of the 20210 G to A Prothrombin Variant

  F.R. Rosendaal;Catharina Jacoba Maria Doggen;A. Zivelin;V.R. Arruda

  965
  Citations

• AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.

  Catherine S. Manno;Amy J. Chew;Sylvia Hutchison;Peter J. Larson

  934
  Citations

• Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.

  Lindsey A. George;Spencer K. Sullivan;Adam Giermasz;John E.J. Rasko;John E.J. Rasko

  784
  Citations

• Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer

  Federico Mingozzi;Yi-Lin Liu;Eric Dobrzynski;Antje Kaufhold

  570
  Citations

• Sustained phenotypic correction of hemophilia B dogs with a factor IX null mutation by liver-directed gene therapy.

  Jane D. Mount;Roland W. Herzog;D. Michael Tillson;Susan A. Goodman

  524
  Citations

• Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism - Pooled analysis of 8 case-control studies including 2310 cases and 3204 controls

  Joseph Emmerich;Frits R. Rosendaal;Marco Cattaneo;Maurizio Margaglione

  489
  Citations

• Long-term correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy.

  Glenn P. Niemeyer;Glenn P. Niemeyer;Roland W. Herzog;Jane Mount;Valder R. Arruda

  379
  Citations

• Reversal of Blindness in Animal Models of Leber Congenital Amaurosis Using Optimized AAV2-mediated Gene Transfer

  Jeannette Bennicelli;John Fraser Wright;John Fraser Wright;Andras Komaromy;Jonathan B Jacobs

  329
  Citations

• Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver

  Federico Mingozzi;Nicole C. Hasbrouck;Etiena Basner-Tschakarjan;Shyrie A. Edmonson;Shyrie A. Edmonson

  281
  Citations

• Assessing the potential for AAV vector genotoxicity in a murine model

  Hojun Li;Nirav Malani;Shari R. Hamilton;Alexander Schlachterman

  275
  Citations

• Muscle-Directed Gene Transfer and Transient Immune Suppression Result in Sustained Partial Correction of Canine Hemophilia B Caused by a Null Mutation

  Roland W. Herzog;Jane D. Mount;Valder R. Arruda;Katherine A. High

  264
  Citations

• Evidence of multiyear factor IX expression by AAV-mediated gene transfer to skeletal muscle in an individual with severe hemophilia B.

  Haiyan Jiang;Glenn F. Pierce;Margareth C. Ozelo;Erich V. de Paula

  256
  Citations

• Lack of germline transmission of vector sequences following systemic administration of recombinant AAV-2 vector in males.

  Valder R. Arruda;Paul A. Fields;Ross Milner;Luanne Wainwright

  213
  Citations

• Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy

  Jonathan D. Finn;Margareth C. Ozelo;Denise E. Sabatino;Helen W. G. Franck

  210
  Citations

• Influence of vector dose on factor IX-specific T and B cell responses in muscle-directed gene therapy

  Roland W. Herzog;Paul A. Fields;Valder R. Arruda;Jeff O. Brubaker

  205
  Citations

• Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1

  Valder R. Arruda;Joerg Schuettrumpf;Roland W. Herzog;Timothy C. Nichols

  205
  Citations

• Role of vector in activation of T cell subsets in immune responses against the secreted transgene product factor IX.

  Paul A. Fields;Dariusz W. Kowalczyk;Valder R. Arruda;Elina Armstrong

  196
  Citations