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Ian E. Alexander

Ian E. Alexander

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
15735
World Ranking
15398
National Ranking
423

Research.com Recognitions

  • 2015 - Fellow of the Australian Academy of Health and Medical Science

Overview

Ian E. Alexander is primarily affiliated with the University of Sydney in Australia. Their research spans biochemistry, genetics, and molecular biology, with significant contributions to medicine. Their work covers numerous subfields such as molecular biology, genetics, cardiology and cardiovascular medicine, immunology, and infectious diseases.

The scientist's main research topics include virus-based gene therapy research, CRISPR and genetic engineering, viral infections and immunology research, viral gastroenteritis research and epidemiology, RNA interference and gene delivery, viral infectious diseases and gene expression in insects, and neurogenetic and muscular disorders research.

Notable recent papers by Ian E. Alexander include:

  • The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis (2020) published in Gastroenterology
  • The diagnostic utility of genome sequencing in a pediatric cohort with suspected mitochondrial disease (2020) published in Genetics in Medicine
  • High-Throughput In Vitro, Ex Vivo, and In Vivo Screen of Adeno-Associated Virus Vectors Based on Physical and Functional Transduction (2020) published in Human Gene Therapy
  • Onasemnogene abeparvovec in spinal muscular atrophy: an Australian experience of safety and efficacy (2022) published in Annals of Clinical and Translational Neurology
  • Restoring the natural tropism of AAV2 vectors for human liver (2020) published in Science Translational Medicine

Frequent coauthors with Ian E. Alexander include:

  • Leszek Lisowski
  • Erhua Zhu
  • Renina Gale Navarro
  • Grant J. Logan
  • Adrian Westhaus

The scientist has published extensively in several journals. The most frequent publication venues are Molecular Therapy - Methods & Clinical Development, Human Gene Therapy, Molecular Therapy, bioRxiv (Cold Spring Harbor Laboratory), and The Journal of Gene Medicine.

Ian E. Alexander was recognized as a Fellow of the Australian Academy of Health and Medical Science in 2015.

Best Publications

  • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

    S. Hacein-Bey-Abina;C. Von Kalle;C. Von Kalle;M. Schmidt;M. P. McCormack

  • Gene therapy clinical trials worldwide to 2012 - an update

    Samantha L. Ginn;Ian E. Alexander;Ian E. Alexander;Michael L. Edelstein;Mohammad R. Abedi

  • Gene therapy clinical trials worldwide to 2017: An update

    Samantha L. Ginn;Anais K. Amaya;Ian E. Alexander;Ian E. Alexander;Michael Edelstein

  • Selection and evaluation of clinically relevant AAV variants in a xenograft liver model

    Leszek Lisowski;Allison P. Dane;Kirk Chu;Yue Zhang

  • Adeno-associated virus vectors preferentially transduce cells in S phase

    D W Russell;A D Miller;I E Alexander

  • Fibroblasts Can Be Genetically Modified to Produce Excitable Cells Capable of Electrical Coupling

    Eddy Kizana;Samantha L. Ginn;David G. Allen;David L. Ross

  • Persistent Expression of Human Clotting Factor IX from Mouse Liver after Intravenous Injection of Adeno-Associated Virus Vectors

    Dwight D. Koeberl;Ian E. Alexander;Christine L. Halbert;David W. Russell

  • Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration.

    C L Halbert;T A Standaert;M L Aitken;I E Alexander

  • The Transcriptional and Functional Properties of Mouse Epiblast Stem Cells Resemble the Anterior Primitive Streak

    Yoji Kojima;Keren Kaufman-Francis;Joshua B. Studdert;Kirsten A. Steiner

  • Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

    Annette Deichmann;Salima Hacein-Bey-Abina;Manfred Schmidt;Manfred Schmidt;Alexandrine Garrigue

  • Gene delivery to the juvenile mouse liver using AAV2/8 vectors.

    Sharon C Cunningham;Allison P Dane;Afroditi Spinoulas;Ian E Alexander;Ian E Alexander

  • Expression and Regulation of Retinoic Acid Receptors in Human Breast Cancer Cells

    Shaun D. Roman;Christine L. Clarke;Rosemary E. Hall;Ian E. Alexander

  • Effects of gamma irradiation on the transduction of dividing and nondividing cells in brain and muscle of rats by adeno-associated virus vectors.

    Ian E. Alexander;David W. Russell;Alexander M. Spence;A. Dusty Miller

  • C2C12 Co‐culture on a fibroblast substratum enables sustained survival of contractile, highly differentiated myotubes with peripheral nuclei and adult fast myosin expression

    S.T. Cooper;A.L. Maxwell;E. Kizana;E. Kizana;M. Ghoddusi

  • AAV2/8-mediated Correction of OTC Deficiency Is Robust in Adult but Not Neonatal Spfash Mice

    Sharon C Cunningham;Afroditi Spinoulas;Kevin H Carpenter;Kevin H Carpenter;Bridget Wilcken;Bridget Wilcken

  • Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity.

    Nicole K. Paulk;Katja Pekrun;Erhua Zhu;Sean Nygaard

  • Progestin inhibition of progesterone receptor gene expression in human breast cancer cells.

    Ian E. Alexander;Christine L. Clarke;John Shine;Robert L. Sutherland

  • Adeno-associated virus serotypes for gene therapeutics

    Leszek Lisowski;Szun Szun Tay;Ian Edward Alexander;Ian Edward Alexander

  • The implementation of newborn screening for spinal muscular atrophy: the Australian experience.

    Didu S. T. Kariyawasam;Didu S. T. Kariyawasam;Jacqueline S. Russell;Veronica Wiley;Veronica Wiley;Ian E. Alexander;Ian E. Alexander

  • Potential of AAV vectors in the treatment of metabolic disease

    I E Alexander;I E Alexander;I E Alexander;S C Cunningham;G J Logan;J Christodoulou;J Christodoulou

Frequent Co-Authors

David Bowen
David Bowen Royal Prince Alfred Hospital
Patrick Bertolino
Patrick Bertolino Centenary Institute of Cancer Medicine and Cell Biology
Stephen I. Alexander
Stephen I. Alexander Children's Hospital at Westmead
Adrian J. Thrasher
Adrian J. Thrasher University College London
Geoffrey W. McCaughan
Geoffrey W. McCaughan University of Sydney
Paul Gissen
Paul Gissen University College London
John Christodoulou
John Christodoulou University of Melbourne
Peter W. Gunning
Peter W. Gunning University of New South Wales
Kathryn N. North
Kathryn N. North University of Melbourne
Simon N. Waddington
Simon N. Waddington University College London

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