World's Best Scientists 2026 revealed!
John Christodoulou

John Christodoulou

D-Index & Metrics

Genetics

D-Index
81
Citations
21858
World Ranking
1533
National Ranking
51

Medicine

D-Index
81
Citations
21962
World Ranking
16739
National Ranking
557

Overview

John Christodoulou is affiliated with the University of Melbourne in Australia and works primarily within the field of Biochemistry, Genetics and Molecular Biology. Their research focuses extensively on molecular biology and genetics, with additional contributions in physiology, oncology, and materials chemistry.

The scientist's main topics of study include:

  • RNA and protein synthesis mechanisms
  • Protein Structure and Dynamics
  • RNA modifications and cancer
  • Peptidase Inhibition and Analysis
  • Enzyme Structure and Function
  • Genomics and Rare Diseases
  • Alzheimer's disease research and treatments

John Christodoulou's recent publications illustrate engagement with co-translational protein folding, ribosome function, and related biochemical processes. Some notable recent papers include:

  • "How Does the Ribosome Fold the Proteome?" (2020) published in Annual Review of Biochemistry
  • "Spontaneous assembly of redox-active iron-sulfur clusters at low concentrations of cysteine" (2021) in Nature Communications
  • "Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein" (2021) in Nature Communications
  • "Interactions between nascent proteins and the ribosome surface inhibit co-translational folding" (2021) in Nature Chemistry
  • "Modulating co-translational protein folding by rational design and ribosome engineering" (2022) in Nature Communications

The scientist collaborates frequently with several co-authors, including:

  • Christopher A. Waudby
  • Lisa D. Cabrita
  • Julian O. Streit
  • Sammy H. S. Chan
  • Tomasz Włodarski

John Christodoulou's work has been published in multiple scientific venues, with the most frequent ones being:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature Chemistry
  • Genetics in Medicine
  • Science Advances

Best Publications

  • Rett syndrome: Revised diagnostic criteria and nomenclature

    Jeffrey L. Neul;Walter E. Kaufmann;Daniel G. Glaze;John Christodoulou

  • Leigh syndrome: Clinical features and biochemical and DNA abnormalities

    Shamima Rahman;R. B. Blok;H. H. M. Dahl;David M. Danks

  • Heteroplasmic mtDNA mutation (T----G) at 8993 can cause Leigh disease when the percentage of abnormal mtDNA is high.

    Y Tatuch;J Christodoulou;A Feigenbaum;J T Clarke

  • Mutations of CDKL5 Cause a Severe Neurodevelopmental Disorder with Infantile Spasms and Mental Retardation

    Linda S. Weaving;John Christodoulou;John Christodoulou;Sarah L. Williamson;Sarah L. Williamson;Kathie L. Friend

  • Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing

    Sarah E. Calvo;Alison G. Compton;Steven G. Hershman;Steven G. Hershman;Sze Chern Lim;Sze Chern Lim

  • Rett Syndrome in Australia: A Review of the Epidemiology

    Crystal L. Laurvick;Nicholas de Klerk;Carol Bower;John Christodoulou

  • The CDKL5 disorder is an independent clinical entity associated with early-onset encephalopathy

    Stephanie Fehr;Meredith Wilson;Meredith Wilson;Jennepher Downs;Jennepher Downs;Simon Williams

  • The Genetic Landscape and Epidemiology of Phenylketonuria

    Alicia Hillert;Yair Anikster;Amaya Belanger-Quintana;Alberto Burlina

  • Mutation of the mitochondrial tyrosyl-tRNA synthetase gene, YARS2, causes myopathy, lactic acidosis, and sideroblastic anemia--MLASA syndrome.

    Lisa G. Riley;Sandra Cooper;Sandra Cooper;Peter Hickey;Joëlle Rudinger-Thirion

  • Patient care standards for primary mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society

    Sumit Parikh;Amy Goldstein;Amel Karaa;Mary Kay Koenig

  • Rett syndrome: clinical review and genetic update

    L S Weaving;C J Ellaway;J Gécz;J Christodoulou

  • Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice.

    Gregory J. Pelka;Catherine M. Watson;Tania Radziewic;Melinda Hayward

  • Phenylketonuria: a review of current and future treatments.

    Naz Al Hafid;John Christodoulou

  • Early onset seizures and Rett-like features associated with mutations in CDKL5.

    Julie C. Evans;Hayley Louise Archer;James Colley;Kirstine Ravn

  • Mutation of C20orf7 disrupts complex I assembly and causes lethal neonatal mitochondrial disease.

    Canny Sugiana;David J. Pagliarini;David J. Pagliarini;Matthew McKenzie;Denise M. Kirby

  • Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome Mecp2 gene dosage effects and BDNF expression

    Mari Kondo;Laura J. Gray;Gregory J. Pelka;John Christodoulou;John Christodoulou

  • Expanded Newborn Screening: Outcome in Screened and Unscreened Patients at Age 6 Years

    Bridget Wilcken;Marion Haas;Pamela Joy;Veronica Wiley

  • RettBASE: The IRSA MECP2 variation database-a new mutation database in evolution.

    John Christodoulou;Andrew Grimm;Tony Maher;Bruce Bennetts;Bruce Bennetts

  • Mutations in MTFMT Underlie a Human Disorder of Formylation Causing Impaired Mitochondrial Translation

    Elena J. Tucker;Steven G. Hershman;Steven G. Hershman;Caroline Köhrer;Casey A. Belcher-Timme;Casey A. Belcher-Timme

  • Treatable childhood neuronopathy caused by mutations in riboflavin transporter RFVT2

    A. Reghan Foley;Manoj P. Menezes;Manoj P. Menezes;Amelie Pandraud;Michael A. Gonzalez

Frequent Co-Authors

David R. Thorburn
David R. Thorburn Murdoch Children's Research Institute
Helen Leonard
Helen Leonard Telethon Kids Institute
Hakon Hakonarson
Hakon Hakonarson Children's Hospital of Philadelphia
Susan M. White
Susan M. White University of Arizona
Mark J. Cowley
Mark J. Cowley Garvan Institute of Medical Research
Zornitza Stark
Zornitza Stark University of Melbourne
Vamsi K. Mootha
Vamsi K. Mootha Harvard Medical School
Tony Roscioli
Tony Roscioli University of New South Wales
Sarah E. Calvo
Sarah E. Calvo Broad Institute
Patrick P.L. Tam
Patrick P.L. Tam University of Sydney

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Genetics in the USA can open doors to a wide range of online degrees and professional opportunities in related health and science fields. For those looking to enter nursing, several no entrance exam nursing schools now offer flexible pathways, making it easier for students to begin their careers without additional testing requirements.

If your interests span the management side of healthcare, a masters in healthcare administration is a great way to gain leadership skills and advance into supervisory roles within healthcare organizations.

Those seeking a faster entry into the workforce may consider online lpn programs, which offer streamlined education options to become a licensed practical nurse in less time.

Advancing your career further is possible with the cheapest online dnp programs, helping nurses achieve the highest level of clinical and leadership expertise at a lower cost.

Best Scientists Citing John Christodoulou

Trending Scientists