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Matthias Gstaiger

Matthias Gstaiger

D-Index & Metrics

Molecular Biology

D-Index
47
Citations
12395
World Ranking
2718
National Ranking
48

Overview

Matthias Gstaiger is affiliated with ETH Zurich in Switzerland and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology, with additional work in Chemistry. Their research encompasses Molecular Biology, Spectroscopy, Oncology, Organic Chemistry, and Cell Biology.

Their main research topics include:

  • Advanced Proteomics Techniques and Applications
  • Mass Spectrometry Techniques and Applications
  • Click Chemistry and Applications
  • Bioinformatics and Genomic Networks
  • Protein Degradation and Inhibitors
  • Ubiquitin and proteasome pathways
  • Enzyme Structure and Function

Gstaiger has published notable papers such as:

  • Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases, 2020, Molecular Cell
  • A Global Screen for Assembly State Changes of the Mitotic Proteome by SEC-SWATH-MS, 2020, Cell Systems
  • PCprophet: a framework for protein complex prediction and differential analysis using proteomic data, 2021, Nature Methods
  • Complex-centric proteome profiling by SEC-SWATH-MS for the parallel detection of hundreds of protein complexes, 2020, Nature Protocols
  • NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency, 2020, eLife

Key frequent co-authors who have collaborated with Gstaiger include:

  • Ruedi Aebersold
  • Fabian Frommelt
  • Federico Uliana
  • Rodolfo Ciuffa
  • Andrea Fossati

The scientist has contributed to several publication venues, with frequent appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Methods
  • Nature Communications
  • Cancer Research
  • Molecular Cell

Best Publications

  • The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

    Dattatreya Mellacheruvu;Zachary Wright;Amber L. Couzens;Jean Philippe Lambert

  • Analysis of protein complexes using mass spectrometry

    Anne-Claude Gingras;Anne-Claude Gingras;Matthias Gstaiger;Brian Raught;Brian Raught;Ruedi Aebersold

  • Skp2 is oncogenic and overexpressed in human cancers

    Matthias Gstaiger;Richard Jordan;Megan Lim;Charles Catzavelos

  • Applying mass spectrometry-based proteomics to genetics, genomics and network biology

    Matthias Gstaiger;Ruedi Aebersold

  • The von Hippel–Lindau tumor suppressor protein is a component of an E3 ubiquitin–protein ligase activity

    Joanna Lisztwan;Georges Imbert;Christiane Wirbelauer;Matthias Gstaiger

  • Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

    Matteo Berti;Arnab Ray Chaudhuri;Saravanabhavan Thangavel;Shivasankari Gomathinayagam

  • A B-cell coactivator of octamer-binding transcription factors

    Matthias Gstaiger;Lea Knoepfel;Oleg Georgiev;Walter Schaffner

  • Quantifying protein interaction dynamics by SWATH mass spectrometry: application to the 14-3-3 system

    Ben C Collins;Ludovic C Gillet;George Rosenberger;George Rosenberger;Hannes L Röst;Hannes L Röst

  • NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase.

    Matthias Habjan;Andreas Pichlmair;Andreas Pichlmair;Richard M. Elliott;Anna K. Överby

  • An integrated workflow for charting the human interaction proteome: insights into the PP2A system

    Timo Glatter;Alexander Wepf;Ruedi Aebersold;Matthias Gstaiger

  • Association of human CUL‐1 and ubiquitin‐conjugating enzyme CDC34 with the F‐box protein p45SKP2: evidence for evolutionary conservation in the subunit composition of the CDC34–SCF pathway

    Joanna Lisztwan;Alain Marti;Hedwig Sutterlüty;Matthias Gstaiger

  • PIMS Modulates Immune Tolerance by Negatively Regulating Drosophila Innate Immune Signaling

    Nouara Lhocine;Paulo S. Ribeiro;Paulo S. Ribeiro;Nicolas Buchon;Alexander Wepf

  • A High-Density Map for Navigating the Human Polycomb Complexome

    Simon Hauri;Federico Comoglio;Makiko Seimiya;Moritz Gerstung

  • Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations

    Danilo Ritz;Maja Vuk;Maja Vuk;Philipp Kirchner;Monika Bug

  • Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling

    Paulo S. Ribeiro;Filipe Josué;Filipe Josué;Alexander Wepf;Michael C. Wehr

  • The Protein Interaction Landscape of the Human CMGC Kinase Group

    Markku Varjosalo;Salla Keskitalo;Audrey Van Drogen;Helka Nurkkala

  • Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

    Markku Varjosalo;Roberto Sacco;Alexey Stukalov;Audrey van Drogen

  • Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.

    Matthias Gstaiger;Brian Luke;Daniel Hess;Edward J. Oakeley

  • An integrated mass spectrometric and computational framework for the analysis of protein interaction networks

    Oliver Rinner;Lukas N. Mueller;Martin Hubálek;Markus Müller

  • Systematic proteomic profiling of the human Polycomb interactome

    Simon Hauri;Federico Comoglio;Makiko Seimiya;Moritz Gerstung

Frequent Co-Authors

Wilhelm Krek
Wilhelm Krek ETH Zurich
Markku Varjosalo
Markku Varjosalo University of Helsinki
Giulio Superti-Furga
Giulio Superti-Furga Medical University of Vienna
Walter Schaffner
Walter Schaffner University of Zurich
Oleg Georgiev
Oleg Georgiev University of Zurich
Keiryn L. Bennett
Keiryn L. Bennett Medical University of Vienna
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute
Ulrike Kutay
Ulrike Kutay ETH Zurich
Marie Malissen
Marie Malissen Aix-Marseille University

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