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Markku Varjosalo

Markku Varjosalo

D-Index & Metrics

Molecular Biology

D-Index
50
Citations
9409
World Ranking
2570
National Ranking
8

Overview

Markku Varjosalo is affiliated with the University of Helsinki in Finland. The primary focus of their research lies within Biochemistry, Genetics, and Molecular Biology, with significant contributions in Medicine. Their extensive work spans several subfields, including Molecular Biology, Immunology, Cell Biology, Oncology, and Cancer Research.

Varjosalo's research addresses a variety of topics, notably Immunodeficiency and Autoimmune Disorders, RNA Research and Splicing, NF-κB Signaling Pathways, Biotin and Related Studies, Genomics and Chromatin Dynamics, Immune Cell Function and Interaction, and RNA modifications and cancer.

Among their recent publications are:

  • Psychedelics promote plasticity by directly binding to BDNF receptor TrkB (2023, Nature Neuroscience)
  • Human transcription factor protein interaction networks (2022, Nature Communications)
  • Combined proximity labeling and affinity purification−mass spectrometry workflow for mapping and visualizing protein interaction networks (2020, Nature Protocols)
  • Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations (2020, Journal of Allergy and Clinical Immunology)
  • Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases (2020, Molecular Cell)

Varjosalo frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nucleic Acids Research, SSRN Electronic Journal, iScience, and Cancers.

Collaboration is a consistent aspect of Varjosalo's work, with frequent co-authors including:

  • Salla Keskitalo
  • Kari Salokas
  • Xiaonan Liu
  • Lisa Gawriyski
  • Tiina Öhman

Best Publications

  • Hedgehog: functions and mechanisms

    Markku Varjosalo;Jussi Taipale

  • Genome-Wide Analysis of ETS-Family DNA-Binding In Vitro and In Vivo

    Gong-Hong Wei;Gwenael Badis;Michael F. Berger;Teemu Kivioja;Teemu Kivioja

  • Identification of pathways regulating cell size and cell-cycle progression by RNAi

    Mikael Björklund;Minna Taipale;Markku Varjosalo;Juha Saharinen

  • Divergence of Hedgehog Signal Transduction Mechanism between Drosophila and Mammals

    Markku Tapio Varjosalo;Songping Li;Jussi Taipale

  • The Protein Interaction Landscape of the Human CMGC Kinase Group

    Markku Varjosalo;Salla Keskitalo;Audrey Van Drogen;Helka Nurkkala

  • An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations

    Xiaonan Liu;Kari Salokas;Fitsum Tamene;Yaming Jiu

  • Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

    Markku Varjosalo;Roberto Sacco;Alexey Stukalov;Audrey van Drogen

  • Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling

    Markku Varjosalo;Mikael Björklund;Fang Cheng;Heidi Syvänen

  • Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers

    Yaming Jiu;Jaakko Lehtimäki;Sari Tojkander;Fang Cheng

  • Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.

    Mikko Turunen;Jason M. Spaeth;Salla Keskitalo;Min Ju Park

  • Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes.

    Meri Kaustio;Emma Haapaniemi;Helka Göös;Timo Hautala

  • Quantitative Proteomics Analysis of Vitreous Humor from Diabetic Retinopathy Patients.

    Sirpa Loukovaara;Helka Nurkkala;Fitsum Tamene;Erika Gucciardo

  • EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion

    Nami Sugiyama;Erika Gucciardo;Olga Tatti;Markku Varjosalo

  • An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.

    Jonna Saarimäki-Vire;Diego Balboa;Mark A. Russell;Juha Saarikettu

  • Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1

    Simon Hauri;Alexander Wepf;Audrey van Drogen;Markku Varjosalo;Markku Varjosalo

  • Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung

    Arne Ittner;Helena Block;Christoph A. Reichel;Markku Varjosalo

  • Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia

    Juha Saarikangas;Pieta K. Mattila;Markku Varjosalo;Miia Bovellan

  • Combined proximity labeling and affinity purification−mass spectrometry workflow for mapping and visualizing protein interaction networks

    Xiaonan Liu;Kari Salokas;Rigbe G. Weldatsadik;Lisa Gawriyski

  • Comprehensive evaluation of coding region point mutations in microsatellite‐unstable colorectal cancer

    Johanna Kondelin;Kari Salokas;Lilli Saarinen;Kristian Ovaska

  • Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resultingworkunderthesameorsimilarlicensetothisone.Theworkmustbeattributedbacktotheoriginalauthorand commercial use is not permitted without specific permission.

    Gong-Hong Wei;Gwenael Badis;Michael F Berger;Teemu Kivioja

Frequent Co-Authors

Jussi Taipale
Jussi Taipale University of Cambridge
Juha Kere
Juha Kere Karolinska Institute
Janna Saarela
Janna Saarela University of Helsinki
Satu Mustjoki
Satu Mustjoki University of Helsinki
Shintaro Katayama
Shintaro Katayama Karolinska Institute
Willem M. de Vos
Willem M. de Vos Wageningen University & Research
Pekka Lappalainen
Pekka Lappalainen University of Helsinki
Olli Kallioniemi
Olli Kallioniemi Karolinska Institute

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