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Medicine

D-Index
103
Citations
34848
World Ranking
7426
National Ranking
3882

Overview

Douglas H. Smith is affiliated with the University of Pennsylvania in the United States. Their research contributions focus primarily within the field of Medicine, with a strong emphasis on Neurology and related subfields such as Epidemiology, Molecular Biology, Emergency Medicine, and Cellular and Molecular Neuroscience.

The scientist's work spans several main topics, notably:

  • Traumatic Brain Injury and Neurovascular Disturbances
  • Traumatic Brain Injury Research
  • Cardiac Arrest and Resuscitation
  • S100 Proteins and Annexins
  • Nerve Injury and Regeneration
  • Automotive and Human Injury Biomechanics
  • Anesthesia and Neurotoxicity Research

Douglas H. Smith has published extensively in various scientific journals. Frequent publication venues include:

  • The Journal of Trauma: Injury, Infection, and Critical Care
  • Acta Neuropathologica
  • Journal of Neurotrauma
  • Brain
  • Acta Neuropathologica Communications

Recent papers authored or co-authored by Douglas H. Smith include:

  • "The PD-1- and LAG-3-targeting bispecific molecule tebotelimab in solid tumors and hematologic cancers: a phase 1 trial" (2023, Nature Medicine)
  • "Ultrasensitive Single Extracellular Vesicle Detection Using High Throughput Droplet Digital Enzyme-Linked Immunosorbent Assay" (2022, Nano Letters)
  • "Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease" (2020, Brain)
  • "Roadmap for Advancing Pre-Clinical Science in Traumatic Brain Injury" (2021, Journal of Neurotrauma)
  • "Detection of astrocytic tau pathology facilitates recognition of chronic traumatic encephalopathy neuropathologic change" (2022, Acta Neuropathologica Communications)

Collaborative work is a notable aspect of Douglas H. Smith's research career. Frequent co-authors include:

  • Victoria E. Johnson
  • William Stewart
  • D. Kacy Cullen
  • Jean-Pierre Dollé
  • Hailong Song

Best Publications

  • Axonal Pathology in Traumatic Brain Injury

    Victoria E. Johnson;William Stewart;Douglas H. Smith

  • Inflammation and white matter degeneration persist for years after a single traumatic brain injury

    Victoria E. Johnson;Janice E. Stewart;Janice E. Stewart;Finn D. Begbie;John Q. Trojanowski

  • Chronic neuropathologies of single and repetitive TBI: substrates of dementia?

    Douglas H. Smith;Victoria E. Johnson;William Stewart

  • Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus

    Daniel H. Lowenstein;Mark J. Thomas;Douglas H. Smith;Tracy K. McIntosh

  • Diffuse axonal injury in head trauma.

    Douglas H. Smith;David F. Meaney;William H. Shull

  • Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?

    Victoria E. Johnson;William Stewart;Douglas H. Smith

  • Widespread Tau and Amyloid-Beta Pathology Many Years After a Single Traumatic Brain Injury in Humans

    Victoria E. Johnson;William Stewart;William Stewart;Douglas H. Smith

  • Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood

    Henrik Zetterberg;Douglas H. Smith;Kaj Blennow

  • Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels.

    John A. Wolf;Peter K. Stys;Theresa Lusardi;David Meaney

  • A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects.

    D H Smith;H D Soares;J S Pierce;K G Perlman

  • Progressive Atrophy and Neuron Death for One Year Following Brain Trauma in the Rat

    Douglas H. Smith;Xiao-Han Chen;Jean E. S. Pierce;John A. Wolf

  • Biomechanics of concussion

    David F. Meaney;Douglas H. Smith

  • Axonal Damage in Traumatic Brain Injury

    Douglas H. Smith;David F. Meaney

  • A new strategy to produce sustained growth of central nervous system axons: continuous mechanical tension.

    Douglas H. Smith;John A. Wolf;David F. Meaney

  • Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury

    HD Soares;RR Hicks;D Smith;TK McIntosh

  • Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration

    Min D. Tang-Schomer;Ankur R. Patel;Peter W. Baas;Douglas H. Smith

  • Evaluation of memory dysfunction following experimental brain injury using the Morris water maze.

    Douglas H. Smith;Koichi Okiyama;Mark J. Thomas;Brian Claussen

  • Enduring cognitive, neurobehavioral and histopathological changes persist for up to one year following severe experimental brain injury in rats

    J.E.S Pierce;D.H Smith;J.Q Trojanowski;T.K McIntosh

  • Cloning, nucleotide sequence, and expression in Escherichia coli of the exotoxin A structural gene of Pseudomonas aeruginosa.

    Gregory L. Gray;Douglas H. Smith;Jane S. Baldridge;Richard N. Harkins

  • Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans.

    Kunihiro Uryu;Xiao-Han Chen;Dan Martinez;Kevin D. Browne

Frequent Co-Authors

Tracy K. McIntosh
Tracy K. McIntosh Media NeuroConsultants
William Stewart
William Stewart University of Glasgow
John A. Wolf
John A. Wolf University of Pennsylvania
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
David I. Graham
David I. Graham University of Glasgow
Thomas A. Gennarelli
Thomas A. Gennarelli University of Pennsylvania
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Ezio Bonvini
Ezio Bonvini Center for Biologics Evaluation and Research
Robert E. Lenkinski
Robert E. Lenkinski The University of Texas Southwestern Medical Center
Douglas B. Cines
Douglas B. Cines University of Pennsylvania

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