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Genetics

D-Index
61
Citations
17370
World Ranking
3044
National Ranking
23

Overview

Janna Saarela is affiliated with the University of Helsinki in Finland and has a significant research presence in the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Their work spans several subfields including Immunology, Genetics, Molecular Biology, Epidemiology, and Hematology.

The main topics covered in Saarela's research include:

  • Immunodeficiency and Autoimmune Disorders
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Multiple Sclerosis Research Studies
  • Cytomegalovirus and herpesvirus research
  • NF-κB Signaling Pathways
  • Skin and Cellular Biology Research

Among recent notable publications are:

  • "Locus for severity implicates CNS resilience in progression of multiple sclerosis", 2023, Nature
  • "Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia", 2021, Cancer Discovery
  • "Genetics of multiple sclerosis: lessons from polygenicity", 2022, The Lancet Neurology
  • "Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients", 2021, Journal of Clinical Immunology
  • "Evaluation and Management of Deficiency of Adenosine Deaminase 2", 2023, JAMA Network Open

Saarela frequently publishes in specific journals, including:

  • Journal of Clinical Immunology
  • Journal of the European Academy of Dermatology and Venereology
  • Zenodo (CERN European Organization for Nuclear Research)
  • Science Immunology
  • Journal of Allergy and Clinical Immunology

The scientist collaborates regularly with several co-authors, including:

  • Virpi Glumoff
  • Meri Kaustio
  • Timo Hautala
  • Mikko Seppänen
  • Markku Varjosalo

Best Publications

  • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

    Stephen Sawcer;Garrett Hellenthal;Matti Pirinen;Chris C. A. Spencer

  • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

    Ashley H. Beecham;Nikolaos A. Patsopoulos;Nikolaos A. Patsopoulos;Dionysia K. Xifara;Mary F. Davis

  • Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia

    Hanna L.M. Koskela;Samuli Eldfors;Pekka Ellonen;Arjan J. van Adrichem

  • Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor

    Tatiana V. Petrova;Taija Mäkinen;Tomi P. Mäkelä;Janna Saarela

  • Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis

    Frida Lundmark;Kristina Duvefelt;Ellen Iacobaeus;Ingrid Kockum

  • The Twin Spine Study: Contributions to a changing view of disc degeneration†

    Michele C. Battié;Tapio Videman;Tapio Videman;Jaakko Kaprio;Laura E. Gibbons

  • Class II HLA interactions modulate genetic risk for multiple sclerosis

    L Moutsianas;L Jostins;A H Beecham;A T Dilthey

  • Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

    Jimmy Z Liu;Johannes Roksund Hov;Trine Folseraas;Trine Folseraas;Eva Ellinghaus

  • Familial combined hyperlipidemia is associated with upstream transcription factor 1 ( USF1 )

    Päivi Pajukanta;Heidi E Lilja;Janet S Sinsheimer;Rita M Cantor

  • A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis.

    Matthew R Lincoln;Alexandre Montpetit;Alexandre Montpetit;M Zameel Cader;M Zameel Cader;Janna Saarela

  • The Short and Long Forms of Type XVIII Collagen Show Clear Tissue Specificities in Their Expression and Location in Basement Membrane Zones in Humans

    Janna Saarela;Marko Rehn;Aarne Oikarinen;Helena Autio-Harmainen

  • Comparison of solution-based exome capture methods for next generation sequencing.

    Anna-Maija Sulonen;Pekka Ellonen;Henrikki Almusa;Maija Lepistö

  • Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3.

    Emma M. Haapaniemi;Meri Kaustio;Hanna L. M. Rajala;Arjan J. van Adrichem

  • Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.

    Eveliina Jakkula;Eveliina Jakkula;Eveliina Jakkula;Virpi Leppa;Virpi Leppa;Anna-Maija Kristiina Sulonen;Anna-Maija Kristiina Sulonen;Teppo Varilo;Teppo Varilo

  • Are data from different gene expression microarray platforms comparable

    Anna-Kaarina Järvinen;Sampsa Hautaniemi;Henrik Edgren;Henrik Edgren;Petri Auvinen

  • Genetic background of extreme violent behavior.

    J. Tiihonen;M-R Rautiainen;H. M. Ollila;E. Repo-Tiihonen

  • The role of the CD58 locus in multiple sclerosis

    Philip L. De Jager;Clare Baecher-Allan;Lisa M. Maier;Ariel T. Arthur

  • Interleukin 1 polymorphisms and intervertebral disc degeneration.

    Svetlana Solovieva;Sanna Kouhia;Päivi Leino-Arjas;Leena Ala-Kokko

  • Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

    Evangelos Evangelou;Ana M. Valdes;Hanneke J. M. Kerkhof;Unnur Styrkarsdottir

  • Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

    Jimmy Z. Liu;Johannes Roksund Hov;Trine Folseraas;Eva Ellinghaus

Frequent Co-Authors

Aarno Palotie
Aarno Palotie University of Helsinki
David A. Hafler
David A. Hafler Yale University
Hanne F. Harbo
Hanne F. Harbo Oslo University Hospital
Pentti J. Tienari
Pentti J. Tienari University of Helsinki
Jan Hillert
Jan Hillert Karolinska Institute
An Goris
An Goris KU Leuven
Stephen Sawcer
Stephen Sawcer University of Cambridge
Stephen L. Hauser
Stephen L. Hauser University of California, San Francisco
Graeme J. Stewart
Graeme J. Stewart University of Sydney
David R. Booth
David R. Booth University of Sydney

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