World's Best Scientists 2026 revealed!
David A. Hafler

David A. Hafler

Award Badge
Immunology
USA
2026

D-Index & Metrics

Immunology

D-Index
155
Citations
95828
World Ranking
104
National Ranking
66

Medicine

D-Index
155
Citations
96172
World Ranking
959
National Ranking
550

Research.com Recognitions

  • 2026 - Research.com Immunology in United States Leader Award
  • 2025 - Research.com Immunology in United States Leader Award
  • 2018 - Member of the National Academy of Medicine (NAM)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

David A. Hafler is affiliated with Yale University in the United States and has contributed extensively to the fields of Medicine and Immunology and Microbiology. Their research spans multiple subfields, including Immunology, Infectious Diseases, Molecular Biology, Neurology, and Oncology.

Their main areas of study focus on immune cell function and interaction, T-cell and B-cell immunology, and COVID-19 clinical research studies. Additional research topics include single-cell and spatial transcriptomics, SARS-CoV-2 and COVID-19 research, immunotherapy and immune responses, and CAR-T cell therapy research.

Key recent publications by David A. Hafler include:

  • Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain (2022, Nature Neuroscience)
  • High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq (2023, Nature Biotechnology)
  • Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children (2021, Immunity)
  • Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19 (2022, Nature Communications)
  • NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data (2021, Communications Biology)

Frequent coauthors collaborating with David A. Hafler include:

  • Steven H. Kleinstein
  • Ruth R. Montgomery
  • Ofer Levy
  • Tomokazu S. Sumida
  • Albert C. Shaw

The scientist has published frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory), ENCODE Datasets, Nature Immunology, Journal of Clinical Investigation, and JCI Insight.

Professional recognition includes membership in prominent organizations such as the National Academy of Medicine since 2018 and the Association of American Physicians.

Best Publications

  • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

    Stephen Sawcer;Garrett Hellenthal;Matti Pirinen;Chris C. A. Spencer

  • FOXP3 + regulatory T cells in the human immune system

    Shimon Sakaguchi;Makoto Miyara;Makoto Miyara;Cristina M. Costantino;Cristina M. Costantino;David A. Hafler;David A. Hafler

  • Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

    Youhai Chen;Vijay K. Kuchroo;Jun-ichi Inobe;David A. Hafler

  • CD4+CD25high Regulatory Cells in Human Peripheral Blood

    Clare Baecher-Allan;Julia A. Brown;Gordon J. Freeman;David A. Hafler

  • Risk alleles for multiple sclerosis identified by a genomewide study.

    David A. Hafler;Alastair Compston;Stephen Sawcer;Mark J. Daly

  • Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

    Vissia Viglietta;Clare Baecher-Allan;Howard L. Weiner;David A. Hafler

  • Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants

    Kyle Kai How Farh;Alexander Marson;Jiang Zhu;Markus Kleinewietfeld

  • Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

    Unknown

  • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

    Ashley H. Beecham;Nikolaos A. Patsopoulos;Nikolaos A. Patsopoulos;Dionysia K. Xifara;Mary F. Davis

  • IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.

    Li Yang;David E. Anderson;Clare Baecher-Allan;William D. Hastings

  • Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

    Markus Kleinewietfeld;Arndt Manzel;Arndt Manzel;Jens Titze;Jens Titze;Heda Kvakan

  • Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

    H. L. Weiner;A. Friedman;A. Miller;S. J. Khoury

  • T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis.

    Kohei Ota;Makoto Matsui;Edgar L. Milford;Glenn A. Mackin

  • Induction and molecular signature of pathogenic TH17 cells

    Youjin Lee;Amit Awasthi;Amit Awasthi;Nir Yosef;Nir Yosef;Francisco Javier Quintana

  • Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.

    Nicole Joller;Ester Lozano;Patrick R. Burkett;Bonny Patel

  • Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

    Philip L De Jager;Philip L De Jager;Xiaoming Jia;Joanne Wang;Paul I W de Bakker

  • Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

    S. Brian Wilson;Sally C. Kent;Kurt T. Patton;Tihamer Orban

  • A high resolution HLA and SNP haplotype map for disease association studies in the extended human MHC

    Paul I W de Bakker;Gil McVean;Pardis C Sabeti;Marcos M Miretti

  • Effects of oral administration of type II collagen on rheumatoid arthritis.

    DE Trentham;RA Dynesius-Trentham;EJ Orav;D Combitchi

  • Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.

    Ana C. Anderson;David E. Anderson;Lisa Bregoli;William D. Hastings

  • Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

    Jingwu Zhang;Silva Markovic-Plese;Blishda Lacet;Jef Raus

Frequent Co-Authors

Howard L. Weiner
Howard L. Weiner Harvard University
Philip L. De Jager
Philip L. De Jager Columbia University
Stephen L. Hauser
Stephen L. Hauser University of California, San Francisco
Vijay K. Kuchroo
Vijay K. Kuchroo Harvard University
Samia J. Khoury
Samia J. Khoury American University of Beirut
Jorge R. Oksenberg
Jorge R. Oksenberg University of California, San Francisco
Stephen Sawcer
Stephen Sawcer University of Cambridge
Kevin C. O’Connor
Kevin C. O’Connor Yale University
John D. Rioux
John D. Rioux University of Montreal
Mark J. Daly
Mark J. Daly Massachusetts General Hospital

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