2022 - Research.com Best Scientist Award
2018 - Member of the National Academy of Medicine (NAM)
Member of the Association of American Physicians
His primary scientific interests are in Immunology, Genetics, Multiple sclerosis, T cell and Allele. His research on Immunology often connects related areas such as Cell biology. He focuses mostly in the field of Genetics, narrowing it down to matters related to Genetic admixture and, in some cases, Centimorgan, Gene mapping, Association mapping and Gene flow.
David A. Hafler works mostly in the field of Multiple sclerosis, limiting it down to concerns involving Pathology and, occasionally, B cell. The study incorporates disciplines such as Experimental autoimmune encephalomyelitis, Molecular biology and Myelin basic protein in addition to T cell. His study looks at the relationship between Allele and topics such as Genotyping, which overlap with Polymorphism.
The scientist’s investigation covers issues in Immunology, Multiple sclerosis, T cell, Immune system and Genetics. His Immunology research is multidisciplinary, relying on both Myelin and Myelin basic protein. His studies deal with areas such as Antibody, Central nervous system and Disease, Pathology as well as Multiple sclerosis.
David A. Hafler has researched T cell in several fields, including Molecular biology, Cytotoxic T cell and Cell biology. David A. Hafler combines subjects such as Cancer research and Cytokine with his study of Immune system. All of his Genetics and Genome-wide association study, Allele, Single-nucleotide polymorphism, Locus and Linkage disequilibrium investigations are sub-components of the entire Genetics study.
His main research concerns Immunology, Multiple sclerosis, Immune system, T cell and Genetics. His Immunology study integrates concerns from other disciplines, such as Cytotoxic T cell and Central nervous system. As part of one scientific family, David A. Hafler deals mainly with the area of Multiple sclerosis, narrowing it down to issues related to the Disease, and often Bioinformatics.
His research investigates the connection between Immune system and topics such as Cancer research that intersect with problems in Immunotherapy and Cancer. His T cell research is multidisciplinary, incorporating elements of Transcriptome and Cell biology. His research in Genome-wide association study intersects with topics in Quantitative trait locus, Genotyping, Allele and Genetic association.
David A. Hafler mainly investigates Immunology, Multiple sclerosis, Genetics, Genome-wide association study and FOXP3. His Immunology study frequently links to other fields, such as Interleukin 12. His Multiple sclerosis research incorporates elements of Central nervous system, Major histocompatibility complex, Antigen, B cell and Disease.
Genetics is closely attributed to Underlying disease in his work. David A. Hafler interconnects Expression quantitative trait loci, Genotyping, Human leukocyte antigen, Allele and Genetic association in the investigation of issues within Genome-wide association study. His work carried out in the field of FOXP3 brings together such families of science as Cytotoxic T cell, Interleukin 21, IL-2 receptor, Interferon gamma and Cell biology.
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CD4+CD25high Regulatory Cells in Human Peripheral Blood
Clare Baecher-Allan;Julia A. Brown;Gordon J. Freeman;David A. Hafler.
Journal of Immunology (2001)
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis
Youhai Chen;Vijay K. Kuchroo;Jun-Ichi Inobe;David A. Hafler.
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Stephen Sawcer;Garrett Hellenthal;Matti Pirinen;Chris C. A. Spencer.
Risk alleles for multiple sclerosis identified by a genomewide study.
David A. Hafler;Alastair Compston;Stephen Sawcer;Mark J. Daly.
The New England Journal of Medicine (2007)
Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis
Vissia Viglietta;Clare Baecher-Allan;Howard L. Weiner;David A. Hafler.
Journal of Experimental Medicine (2004)
FOXP3 + regulatory T cells in the human immune system
Shimon Sakaguchi;Shimon Sakaguchi;Makoto Miyara;Makoto Miyara;Cristina M. Costantino;Cristina M. Costantino;David A. Hafler;David A. Hafler.
Nature Reviews Immunology (2010)
IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.
Li Yang;David E. Anderson;Clare Baecher-Allan;William D. Hastings.
Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants
Kyle Kai How Farh;Alexander Marson;Jiang Zhu;Markus Kleinewietfeld.
Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens
H. L. Weiner;A. Friedman;A. Miller;S. J. Khoury.
Annual Review of Immunology (1994)
T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis
Kohei Ota;Makoto Matsui;Edgar L. Milford;Glenn A. Mackin.
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