D-Index & Metrics Best Publications
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D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 135 Citations 72,816 386 World Ranking 62 National Ranking 45
Medicine D-index 142 Citations 77,677 461 World Ranking 596 National Ranking 355
Best Scientists D-index 160 Citations 98,469 681 World Ranking 850 National Ranking 547

Research.com Recognitions

Awards & Achievements

2022 - Research.com Best Scientist Award

2018 - Member of the National Academy of Medicine (NAM)

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Immune system
  • Internal medicine

His primary scientific interests are in Immunology, Genetics, Multiple sclerosis, T cell and Allele. His research on Immunology often connects related areas such as Cell biology. He focuses mostly in the field of Genetics, narrowing it down to matters related to Genetic admixture and, in some cases, Centimorgan, Gene mapping, Association mapping and Gene flow.

David A. Hafler works mostly in the field of Multiple sclerosis, limiting it down to concerns involving Pathology and, occasionally, B cell. The study incorporates disciplines such as Experimental autoimmune encephalomyelitis, Molecular biology and Myelin basic protein in addition to T cell. His study looks at the relationship between Allele and topics such as Genotyping, which overlap with Polymorphism.

His most cited work include:

  • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis (1970 citations)
  • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis (1970 citations)
  • Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis (1838 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Immunology, Multiple sclerosis, T cell, Immune system and Genetics. His Immunology research is multidisciplinary, relying on both Myelin and Myelin basic protein. His studies deal with areas such as Antibody, Central nervous system and Disease, Pathology as well as Multiple sclerosis.

David A. Hafler has researched T cell in several fields, including Molecular biology, Cytotoxic T cell and Cell biology. David A. Hafler combines subjects such as Cancer research and Cytokine with his study of Immune system. All of his Genetics and Genome-wide association study, Allele, Single-nucleotide polymorphism, Locus and Linkage disequilibrium investigations are sub-components of the entire Genetics study.

He most often published in these fields:

  • Immunology (59.74%)
  • Multiple sclerosis (38.82%)
  • T cell (31.11%)

What were the highlights of his more recent work (between 2010-2021)?

  • Immunology (59.74%)
  • Multiple sclerosis (38.82%)
  • Immune system (20.78%)

In recent papers he was focusing on the following fields of study:

His main research concerns Immunology, Multiple sclerosis, Immune system, T cell and Genetics. His Immunology study integrates concerns from other disciplines, such as Cytotoxic T cell and Central nervous system. As part of one scientific family, David A. Hafler deals mainly with the area of Multiple sclerosis, narrowing it down to issues related to the Disease, and often Bioinformatics.

His research investigates the connection between Immune system and topics such as Cancer research that intersect with problems in Immunotherapy and Cancer. His T cell research is multidisciplinary, incorporating elements of Transcriptome and Cell biology. His research in Genome-wide association study intersects with topics in Quantitative trait locus, Genotyping, Allele and Genetic association.

Between 2010 and 2021, his most popular works were:

  • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis (1970 citations)
  • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis (1970 citations)
  • Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants (1196 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Internal medicine

David A. Hafler mainly investigates Immunology, Multiple sclerosis, Genetics, Genome-wide association study and FOXP3. His Immunology study frequently links to other fields, such as Interleukin 12. His Multiple sclerosis research incorporates elements of Central nervous system, Major histocompatibility complex, Antigen, B cell and Disease.

Genetics is closely attributed to Underlying disease in his work. David A. Hafler interconnects Expression quantitative trait loci, Genotyping, Human leukocyte antigen, Allele and Genetic association in the investigation of issues within Genome-wide association study. His work carried out in the field of FOXP3 brings together such families of science as Cytotoxic T cell, Interleukin 21, IL-2 receptor, Interferon gamma and Cell biology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

CD4+CD25high Regulatory Cells in Human Peripheral Blood

Clare Baecher-Allan;Julia A. Brown;Gordon J. Freeman;David A. Hafler.
Journal of Immunology (2001)

2434 Citations

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

Youhai Chen;Vijay K. Kuchroo;Jun-Ichi Inobe;David A. Hafler.
Science (1994)

2400 Citations

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Stephen Sawcer;Garrett Hellenthal;Matti Pirinen;Chris C. A. Spencer.
Nature (2011)

2262 Citations

Risk alleles for multiple sclerosis identified by a genomewide study.

David A. Hafler;Alastair Compston;Stephen Sawcer;Mark J. Daly.
The New England Journal of Medicine (2007)

2231 Citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

Vissia Viglietta;Clare Baecher-Allan;Howard L. Weiner;David A. Hafler.
Journal of Experimental Medicine (2004)

2115 Citations

FOXP3 + regulatory T cells in the human immune system

Shimon Sakaguchi;Shimon Sakaguchi;Makoto Miyara;Makoto Miyara;Cristina M. Costantino;Cristina M. Costantino;David A. Hafler;David A. Hafler.
Nature Reviews Immunology (2010)

2110 Citations

IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.

Li Yang;David E. Anderson;Clare Baecher-Allan;William D. Hastings.
Nature (2008)

1233 Citations

Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants

Kyle Kai How Farh;Alexander Marson;Jiang Zhu;Markus Kleinewietfeld.
Nature (2015)

1204 Citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

H. L. Weiner;A. Friedman;A. Miller;S. J. Khoury.
Annual Review of Immunology (1994)

1117 Citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

Kohei Ota;Makoto Matsui;Edgar L. Milford;Glenn A. Mackin.
Nature (1990)

1038 Citations

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