Pentti J. Tienari

Overview

Best Publications

• A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

  Alan E. Renton;Elisa Majounie;Adrian James Waite;Javier Simón-Sánchez;Javier Simón-Sánchez

  4892
  Citations

• Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

  Stephen Sawcer;Garrett Hellenthal;Matti Pirinen;Chris C. A. Spencer

  3044
  Citations

• Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

  Mike A Nalls;Cornelis Blauwendraat;Costanza L Vallerga;Karl Heilbron

  2354
  Citations

• Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

  Ashley H. Beecham;Nikolaos A. Patsopoulos;Nikolaos A. Patsopoulos;Dionysia K. Xifara;Mary F. Davis

  1397
  Citations

• Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

  Elisa Majounie;Alan E. Renton;Kin Mok;Elise G. P. Dopper;Elise G. P. Dopper

  1367
  Citations

• RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

  Christopher J. Donnelly;Ping-Wu Zhang;Jacqueline T. Pham;Aaron R. Haeusler

  1017
  Citations

• Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

  Tobias Hartmann;Sophie C. Bieger;Babara Brühl;Pentti J. Tienari

  959
  Citations

• Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

  Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Alan E. Renton;Nicola Ticozzi

  700
  Citations

• Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study

  Maarit Tanskanen;Terhi Peuralinna;Tuomo Polvikoski;Irma-Leena Notkola

  613
  Citations

• A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

  Petra Pasanen;Liisa Myllykangas;Maija Siitonen;Anna Raunio

  611
  Citations

• Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers.

  Nina Mars;Jukka T Koskela;Pietari Ripatti;Tuomo T J Kiiskinen

  527
  Citations

• Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

  Ruth Chia;Marya S. Sabir;Sara Bandres-Ciga

  454
  Citations

• A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis.

  Matthew R Lincoln;Alexandre Montpetit;Alexandre Montpetit;M Zameel Cader;M Zameel Cader;Janna Saarela

  395
  Citations

• A randomised, double blind, placebo controlled trial with vitamin D3 as an add on treatment to interferon β-1b in patients with multiple sclerosis

  Merja Soilu-Hänninen;Julia Åivo;Britt Marie Lindström;Irina Elovaara

  377
  Citations

• Genomewide Scan of Multiple Sclerosis in Finnish Multiplex Families

  Satu Kuokkanen;Michele Gschwend;John D. Rioux;Mark J. Daly

  364
  Citations

• Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.

  Cornelis Blauwendraat;Karl Heilbron;Costanza L. Vallerga;Sara Bandres-Ciga

  361
  Citations

• Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.

  Hannu Laaksovirta;Terhi Peuralinna;Jennifer C Schymick;Sonja W Scholz;Sonja W Scholz

  302
  Citations

• Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.

  Eveliina Jakkula;Eveliina Jakkula;Eveliina Jakkula;Virpi Leppa;Virpi Leppa;Anna-Maija Kristiina Sulonen;Anna-Maija Kristiina Sulonen;Teppo Varilo;Teppo Varilo

  287
  Citations

• A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2.

  Satu Kuokkanen;Mats Sundvall;Joseph D. Terwilliger;Pentti J. Tienari

  254
  Citations

• Genome-Wide Analyses Identify KIF5A as a Novel ALS Gene

  Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Nicola Ticozzi

  8
  Citations