World's Best Scientists 2026 revealed!
Wilhelm Krek

Wilhelm Krek

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
29028
World Ranking
6141
National Ranking
116

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Wilhelm Krek was affiliated with ETH Zurich in Switzerland. Their research centered primarily in the fields of Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Cancer Research, Oncology, and Computational Theory and Mathematics.

The scientist contributed to multiple topics including:

  • Cancer, Hypoxia, and Metabolism
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Melanoma and MAPK Pathways
  • Cutaneous Melanoma Detection and Management
  • Computational Drug Discovery Methods

Krek's publication record includes their research appearing in venues such as:

  • Genomics
  • bioRxiv (Cold Spring Harbor Laboratory)

Their recent scientific papers include:

  • Identification of HIF-dependent alternative splicing in gastrointestinal cancers and characterization of a long, coding isoform of SLC35A3, 2021, Genomics
  • Dynamic changes of genomic and transcriptomic tumor diversity during melanoma progression, 2021, bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators in their work consisted of Philipp Markolin, Natalie R. Davidson, Christian Hirt, Christophe D. Chabbert, and Nicola Zamboni.

Krek's research involved complex areas such as RNA splicing and cancer biology, with a focus on mechanisms related to tumor diversity and hypoxia in cancer. Their studies integrated computational methodologies alongside molecular and genetic investigations, reflecting a cross-disciplinary approach.

They were recognized as a member of the European Molecular Biology Organization (EMBO), a distinction reflecting involvement in the wider molecular biology community.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL

    Peter Staller;Jitka Sulitkova;Joanna Lisztwan;Holger Moch

  • Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

    William G. Kaelin;Wilhelm Krek;William R. Sellers;James A. DeCaprio

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells.

    Hedwig Sutterlüty;Eric Chatelain;Alain Marti;Christiane Wirbelauer

  • Skp2 is oncogenic and overexpressed in human cancers

    Matthias Gstaiger;Richard Jordan;Megan Lim;Charles Catzavelos

  • Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

    Wilhelm Krek;Mark E. Ewen;Suman Shirodkar;Zoltàn Arany

  • Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.

    W. Krek;E. A. Nigg

  • 3D cell culture systems modeling tumor growth determinants in cancer target discovery

    Claudio R. Thoma;Miriam Zimmermann;Irina Agarkova;Jens M. Kelm

  • The von Hippel–Lindau tumor suppressor protein is a component of an E3 ubiquitin–protein ligase activity

    Joanna Lisztwan;Georges Imbert;Christiane Wirbelauer;Matthias Gstaiger

  • Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint.

    Wilhelm Krek;Gangfeng Xu;David M. Livingston

  • A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1

    Charles Spruck;Heimo Strohmaier;Mark Watson;Adrian P.L Smith

  • Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL

    Alexander Hergovich;Joanna Lisztwan;Robert Barry;Pia Ballschmieter

  • High Sensitivity Detection of Plasma Proteins by Multiple Reaction Monitoring of N-Glycosites

    Jianru Stahl-Zeng;Vinzenz Lange;Reto Ossola;Katrin Eckhardt

  • Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.

    W. Krek;E.A. Nigg

  • Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy

    Jaya Krishnan;Marianne Suter;Renata Windak;Tatiana Krebs

  • Interaction between ubiquitin–protein ligase SCF SKP2 and E2F-1 underlies the regulation of E2F-1 degradation

    Alain Marti;Christopher Wirbelauer;Martin Scheffner;Wilhelm Krek

  • Early allelic selection in maize as revealed by ancient DNA

    Viviane Jaenicke-Després;Ed S. Buckler;Bruce D. Smith;M. Thomas P. Gilbert

  • Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system

    Jaya Krishnan;Carsten Danzer;Tatiana Simka;Josef Ukropec

  • PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis

    Nabil Djouder;Roland D Tuerk;Marianne Suter;Paolo Salvioni

Frequent Co-Authors

Holger Moch
Holger Moch University of Zurich
Peter J. Wild
Peter J. Wild Frankfurt Institute for Advanced Studies
Erich A. Nigg
Erich A. Nigg University of Basel
Evelina Gatti
Evelina Gatti Aix-Marseille University
Silke Gillessen
Silke Gillessen Universita della Svizzera Italiana
David M. Livingston
David M. Livingston Harvard University
Daniel Hess
Daniel Hess Friedrich Miescher Institute
Shazib Pervaiz
Shazib Pervaiz National University of Singapore

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