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David M. Livingston

David M. Livingston

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Molecular Biology
USA
2023

D-Index & Metrics

Molecular Biology

D-Index
138
Citations
81749
World Ranking
137
National Ranking
88

Research.com Recognitions

  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2012 - Robert J. and Claire Pasarow Foundation Medical Research Award
  • 2001 - Fellow of the American Academy of Arts and Sciences
  • 1995 - Member of the National Academy of Sciences
  • 1990 - Member of the National Academy of Medicine (NAM)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

David M. Livingston was a researcher affiliated with Harvard University in the United States. Their work primarily focused on the field of biochemistry, genetics, and molecular biology, with notable contributions in molecular biology, oncology, cancer research, geophysics, and physiology.

The main topics covered in their research included:

  • DNA repair mechanisms
  • CRISPR and genetic engineering
  • PARP inhibition in cancer therapy
  • Telomeres, telomerase, and senescence
  • RNA and protein synthesis mechanisms
  • Cancer genomics and diagnostics
  • RNA research and splicing

David M. Livingston published studies in multiple high-profile scientific venues. Frequent publication venues included:

  • Proceedings of the National Academy of Sciences
  • Nature Communications
  • Nature
  • Cancer Cell
  • RadioGraphics

Significant papers authored or co-authored by them include:

  • "BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage" (2021, Nature Communications)
  • "BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2-RAD52" (2021, Nature)
  • "RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci" (2020, Proceedings of the National Academy of Sciences)
  • "BRCA1/Trp53 heterozygosity and replication stress drive esophageal cancer development in a mouse model" (2021, Proceedings of the National Academy of Sciences)
  • "Opening a Door to PARP Inhibitor-Induced Lethality in HR-Proficient Human Tumor Cells" (2020, Cancer Cell)

The scientist frequently collaborated with other researchers, including:

  • Elodie Hatchi
  • Jekaterina Vohhodina
  • Liana Goehring
  • Qing Kong
  • Vladimir V. Botchkarev

David M. Livingston received several professional honors during their career. These included:

  • Robert J. and Claire Pasarow Foundation Medical Research Award (2012)
  • Fellow of the American Academy of Arts and Sciences (2001)
  • Member of the National Academy of Sciences (1995)
  • Member of the National Academy of Medicine (1990)
  • Member of the Association of American Physicians

Best Publications

  • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

    David A. Barbie;Pablo Tamayo;Jesse S. Boehm;So Young Kim

  • SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

    James A. DeCaprio;John W. Ludlow;James Figge;Jin-Yuh Shew

  • Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

    Ralph Scully;Junjie Chen;Annemieke Plug;Yonghong Xiao

  • Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

    Chryssa Kanellopoulou;Stefan A. Muljo;Andrew L. Kung;Shridar Ganesan

  • Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

    L. Eric Huang;Zoltan Arany;David M. Livingston;H. Franklin Bunn

  • Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

    Mark E. Ewen;Hayla K. Sluss;Charles J. Sherr;Hitoshi Matsushime

  • Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

    R Eckner;M E Ewen;D Newsome;M Gerdes

  • Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

    Ralph Scully;Junjie Chen;Robert L Ochs;Kathleen Keegan

  • Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300

    Tso Pang Yao;Suk P. Oh;Miriam Fuchs;Nai Dong Zhou

  • The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element.

    James A. DeCaprio;John W. Ludlow;Dennis Lynch;Yusuke Furukawa

  • Role of T-bet in Commitment of TH1 Cells Before IL-12-Dependent Selection

    Alan C. Mullen;Frances A. High;Anne S. Hutchins;Hubert W. Lee

  • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

    Xiao Qiang Qin;David M. Livingston;William G. Kaelin;Peter D. Adams

  • A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells

    Hidesato Ogawa;Kei-ichiro Ishiguro;Stefan Gaubatz;David M. Livingston

  • Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

    William G. Kaelin;Wilhelm Krek;William R. Sellers;James A. DeCaprio

  • An essential role for p300/CBP in the cellular response to hypoxia

    Zoltàn Arany;L. Eric Huang;Richard Eckner;Shoumo Bhattacharya

  • Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

    Marikki Laiho;James A. DeCaprio;John W. Ludlow;David M. Livingston

  • Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2

    Bing Xia;Qing Sheng;Koji Nakanishi;Akihiro Ohashi

  • E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

    Seth J Field;Seth J Field;Fong-Ying Tsai;Fong-Ying Tsai;Frank Kuo;Ana M Zubiaga;Ana M Zubiaga

  • X chromosomal abnormalities in basal-like human breast cancer

    Andrea L. Richardson;Zhigang C. Wang;Arcangela De Nicolo;Arcangela De Nicolo;Xin Lu

  • Binding and modulation of p53 by p300/CBP coactivators

    Nancy L. Lill;Steven R. Grossman;Doron Ginsberg;Doron Ginsberg;James DeCaprio

Frequent Co-Authors

Andrew L. Kung
Andrew L. Kung Memorial Sloan Kettering Cancer Center
James A. DeCaprio
James A. DeCaprio Harvard University
William G. Kaelin
William G. Kaelin Harvard University
Ronny Drapkin
Ronny Drapkin University of Pennsylvania
Ralph Scully
Ralph Scully Beth Israel Deaconess Medical Center
George J. Todaro
George J. Todaro Fred Hutchinson Cancer Research Center
Zoltan Arany
Zoltan Arany University of Pennsylvania
Daniel G. Tenen
Daniel G. Tenen National University of Singapore
Myles Brown
Myles Brown Harvard University
James D. Griffin
James D. Griffin Harvard University

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