World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
59
Citations
26069
World Ranking
3193
National Ranking
1388

Overview

Ralph Scully is affiliated with Beth Israel Deaconess Medical Center in the United States. Their research focuses primarily within the broad field of Biochemistry, Genetics and Molecular Biology, with particular emphasis on Molecular Biology, Genetics, Cancer Research, Oncology, and Pathology and Forensic Medicine.

The scientist's main research topics include:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing
  • Cancer Genomics and Diagnostics
  • Mitochondrial Function and Pathology
  • PARP inhibition in cancer therapy

Ralph Scully has contributed to various academic publications, predominantly in high-impact journals. Frequent publication venues include:

  • Nature Genetics
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • Nature
  • Nature Communications

Recent notable papers authored or coauthored by Scully are:

  • Patterns of somatic structural variation in human cancer genomes, 2020, Nature
  • Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing, 2020, Nature Genetics
  • Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer, 2020, Nature Genetics
  • Genomic footprints of activated telomere maintenance mechanisms in cancer, 2020, Nature Communications
  • FANCM regulates repair pathway choice at stalled replication forks, 2021, Molecular Cell

Coauthorship collaborations have involved several frequent partners, including:

  • Kadir C. Akdemir
  • Isidro Cortés-Ciriano
  • Yilong Li
  • Peter J. Park
  • Nicholas A. Willis

Best Publications

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

    Ralph Scully;Junjie Chen;Annemieke Plug;Yonghong Xiao

  • INVOLVEMENT OF THE TIP60 HISTONE ACETYLASE COMPLEX IN DNA REPAIR AND APOPTOSIS

    Tsuyoshi Ikura;Vasily V Ogryzko;Mikhail Grigoriev;Regina Groisman

  • Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

    Ralph Scully;Junjie Chen;Robert L Ochs;Kathleen Keegan

  • DNA double-strand break repair-pathway choice in somatic mammalian cells.

    Ralph Scully;Arvind Panday;Rajula Elango;Nicholas A. Willis

  • SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

    Philipp Oberdoerffer;Shaday Michan;Michael McVay;Raul Mostoslavsky

  • Patterns of somatic structural variation in human cancer genomes

    Yilong Li;Nicola D Roberts;Jeremiah A Wala;Jeremiah A Wala;Ofer Shapira;Ofer Shapira

  • In search of the tumour-suppressor functions of BRCA1 and BRCA2

    Ralph Scully;David M. Livingston

  • Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

    Junjie Chen;Daniel P. Silver;Deepika Walpita;Sharon B. Cantor

  • Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

    Randal S. Tibbetts;David Cortez;Kathryn M. Brumbaugh;Ralph Scully

  • Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

    Craig H. Bassing;Katrin F. Chua;Jo Ann Sekiguchi;Heikyung Suh

  • BRCA1 is a component of the RNA polymerase II holoenzyme

    Ralph Scully;Stephen F. Anderson;David M. Chao;Wanjiang Wei

  • The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

    Tso-Pang Yao;Gregory Ku;Naidong Zhou;Ralph Scully

  • Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

    Isidro Cortés-Ciriano;Jake June-Koo Lee;Ruibin Xi;Dhawal Jain

  • Mechanisms of double-strand break repair in somatic mammalian cells.

    Andrea J. Hartlerode;Ralph Scully

  • Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

    Cindy A. Wilson;Lillian Ramos;Maria R. Villaseñor;Karl H. Anders

  • Genetic analysis of BRCA1 function in a defined tumor cell line.

    Ralph Scully;Shridar Ganesan;Katerina Vlasakova;Junjie Chen

  • Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

    Ashish Juvekar;Laura N. Burga;Hai Hu;Elaine P. Lunsford

  • Role of mammalian Mre11 in classical and alternative nonhomologous end joining

    Anyong Xie;Amy Kwok;Ralph Scully

  • BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway.

    Junjie Chen;Daniel P. Silver;Sharon B. Cantor;David M. Livingston

Frequent Co-Authors

David M. Livingston
David M. Livingston Harvard University
Junjie Chen
Junjie Chen The University of Texas MD Anderson Cancer Center
John M. Asara
John M. Asara Beth Israel Deaconess Medical Center
Gerburg M. Wulf
Gerburg M. Wulf Beth Israel Deaconess Medical Center
Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
Lewis C. Cantley
Lewis C. Cantley Harvard University
Jean Feunteun
Jean Feunteun Institut Gustave Roussy
Costas A. Lyssiotis
Costas A. Lyssiotis University of Michigan–Ann Arbor
Roel G.W. Verhaak
Roel G.W. Verhaak The Jackson Laboratory
Craig H. Bassing
Craig H. Bassing Children's Hospital of Philadelphia

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring genetics opens many doors in healthcare and life sciences. For students seeking flexible education or complementary skills, several online options can expand their career possibilities. One popular route is medical coder certification, which provides essential knowledge for working with genetic data in clinical and billing roles.

Those interested in patient care may consider programs from nursing colleges with high acceptance rates. These accessible options help future nurses start their careers quickly, often working alongside genetics specialists.

If you're drawn to leadership or administration, pursuing a healthcare management degree online or an health administration degree online can prepare you for supervisory roles in hospitals, research centers, and biotech companies.

These related programs offer flexible pathways for those looking to bridge genetics with other in-demand healthcare fields, building a diverse and future-ready skill set.

Best Scientists Citing Ralph Scully

Trending Scientists