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Biology and Biochemistry

D-Index
52
Citations
14772
World Ranking
16478
National Ranking
6821

Overview

Gerburg M. Wulf is affiliated with Beth Israel Deaconess Medical Center in the United States. Their research spans extensively across medicine and biochemistry, genetics, and molecular biology, with a particular focus on oncology and related subfields.

The scientist's primary fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these areas, their research emphasizes subfields such as:

  • Oncology
  • Molecular Biology
  • Cancer Research
  • Pulmonary and Respiratory Medicine
  • Immunology

Major research topics covered in their publications are diverse and include:

  • PARP inhibition in cancer therapy
  • Advanced Breast Cancer Therapies
  • Cancer Genomics and Diagnostics
  • Cancer Immunotherapy and Biomarkers
  • HER2/EGFR in Cancer Research
  • DNA Repair Mechanisms
  • BRCA gene mutations in cancer

Gerburg M. Wulf has contributed to numerous scientific papers, some of the recent ones are:

  • TBCRC 048: Phase II Study of Olaparib for Metastatic Breast Cancer and Mutations in Homologous Recombination-Related Genes (2020), Journal of Clinical Oncology
  • Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy (2021), Cell
  • Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer (2020), Nature Communications
  • Effect of Eribulin With or Without Pembrolizumab on Progression-Free Survival for Patients With Hormone Receptor-Positive, ERBB2-Negative Metastatic Breast Cancer (2020), JAMA Oncology
  • TBCRC 048: A phase II study of olaparib monotherapy in metastatic breast cancer patients with germline or somatic mutations in DNA damage response (DDR) pathway genes (Olaparib Expanded) (2020), Journal of Clinical Oncology

Their frequent collaborators include:

  • Yujing J. Heng
  • Eric P. Winer
  • Felipe Batalini
  • Vanessa C. Bret-Mounet
  • Gabrielle M. Baker

Gerburg's research has been published predominantly in venues such as:

  • Cancer Research
  • Journal of Clinical Oncology
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • JCO Precision Oncology

Best Publications

  • The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein.

    Pei Jung Lu;Gerburg Wulf;Xiao Zhen Zhou;Peter Davies

  • Regulation of NF-κB Signaling by Pin1-Dependent Prolyl Isomerization and Ubiquitin-Mediated Proteolysis of p65/RelA

    Akihide Ryo;Futoshi Suizu;Yasuhiro Yoshida;Kilian Perrem

  • Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1

    Gerburg M. Wulf;Akihide Ryo;Gerald G. Wulf;Sam W. Lee

  • Pin1 regulates turnover and subcellular localization of β-catenin by inhibiting its interaction with APC

    Akihide Ryo;Masafumi Nakamura;Gerburg Wulf;Yih Cherng Liou

  • The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

    Lucia Pastorino;Anyang Sun;Anyang Sun;Pei-Jung Lu;Xiao Zhen Zhou

  • PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells

    William J. Israelsen;Talya L. Dayton;Shawn M. Davidson;Brian P. Fiske

  • PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

    Constantia Pantelidou;Olmo Sonzogni;Mateus De Oliveria Taveira;Anita K. Mehta

  • The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response

    Hongwu Zheng;Han You;Xiao Zhen Zhou;Stephen A. Murray

  • Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

    Ashish Juvekar;Laura N. Burga;Hai Hu;Elaine P. Lunsford

  • Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

    Hai Hu;Ashish Juvekar;Costas A. Lyssiotis;Evan C. Lien

  • Open-label Clinical Trial of Niraparib Combined With Pembrolizumab for Treatment of Advanced or Metastatic Triple-Negative Breast Cancer.

    Shaveta Vinayak;Shaveta Vinayak;Sara M. Tolaney;Lee Schwartzberg;Monica Mita

  • TBCRC 048: Phase II Study of Olaparib for Metastatic Breast Cancer and Mutations in Homologous Recombination-Related Genes.

    Nadine M Tung;Nadine M Tung;Mark E Robson;Steffen Ventz;Cesar A Santa-Maria

  • PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.

    Akihide Ryo;Yih Cherng Liou;Gerburg Wulf;Masafumi Nakamura

  • The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer.

    Gustavo Ayala;Dagong Wang;Gerburg Wulf;Anna Frolov

  • Role of Pin1 in the Regulation of p53 Stability and p21 Transactivation, and Cell Cycle Checkpoints in Response to DNA Damage

    Gerburg M. Wulf;Yih-Cherng Liou;Akihide Ryo;Sam W. Lee

  • Phosphorylation-specific prolyl isomerization: is there an underlying theme?

    Gerburg Wulf;Greg Finn;Futoshi Suizu;Kun Ping Lu

  • Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer.

    Akihide Ryo;Yih-Cherng Liou;Kun Ping Lu;Gerburg Wulf

  • Phase I/II Study of Trastuzumab in Combination With Everolimus (RAD001) in Patients With HER2-Overexpressing Metastatic Breast Cancer Who Progressed on Trastuzumab-Based Therapy

    Phuong Khanh Morrow;Gerburg M. Wulf;Joe Ensor;Daniel J. Booser

  • Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis

    Gerburg Wulf;Priti Garg;Yih-Cherng Liou;Dirk Iglehart

  • Erratum: The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-Β production (Nature (2006) 440, (528-534))

    L. Pastorino;A. Sun;P. J. Lu;X. Z. Zhou

Frequent Co-Authors

Lewis C. Cantley
Lewis C. Cantley Harvard University
Kun Ping Lu
Kun Ping Lu Beth Israel Deaconess Medical Center
Eric P. Winer
Eric P. Winer Yale University
Ursula A. Matulonis
Ursula A. Matulonis Harvard University
John M. Asara
John M. Asara Beth Israel Deaconess Medical Center
Ian E. Krop
Ian E. Krop Harvard University
Xiao Zhen Zhou
Xiao Zhen Zhou Beth Israel Deaconess Medical Center
Gordon B. Mills
Gordon B. Mills Oregon Health & Science University
Akihide Ryo
Akihide Ryo Yokohama City University
Sara M. Tolaney
Sara M. Tolaney Harvard University

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