2026 André Nussenzweig: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Molecular Biology	107	408	373	235	210	302	47865

Research.com Recognitions

2019 - Member of the National Academy of Medicine (NAM)

Overview

André Nussenzweig is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on the fields of biochemistry, genetics, and molecular biology, with a significant contribution to medicine. The areas of study further specialize into molecular biology, oncology, genetics, plant science, and cancer research.

The scientist's work covers several main topics related to genomic integrity and cancer biology. These include DNA repair mechanisms, CRISPR and genetic engineering, PARP inhibition in cancer therapy, genomics and chromatin dynamics, epigenetics and DNA methylation, chromosomal and genetic variations, and cancer genomics and diagnostics.

Recent publications by André Nussenzweig illustrate active research in molecular and cancer biology. Some of their notable papers include:

"Human topoisomerases and their roles in genome stability and organization," 2022, published in Nature Reviews Molecular Cell Biology
"Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance," 2021, published in Nature Communications
"Neuronal enhancers are hotspots for DNA single-strand break repair," 2021, published in Nature
"Repeat expansions confer WRN dependence in microsatellite-unstable cancers," 2020, published in Nature
"ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis," 2020, published in Nature Communications

Frequent collaborators in their research include Elsa Callén, Wei Wu, Dali Zong, Raphael Pavani, and Jacob Paiano. The partnerships with these co-authors reflect ongoing collaboration in domains such as DNA repair and cancer biology.

André Nussenzweig has contributed extensively to various publication venues, predominantly in journals that emphasize molecular and cellular biology. These venues include:

bioRxiv (Cold Spring Harbor Laboratory)
Molecular Cell
eLife
Nature Communications
Cancer Research

Recognition of their work includes election as a Member of the National Academy of Medicine (NAM) in 2019, indicating peer acknowledgment within the medical and scientific community.

Best Publications

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Samuel F. Bunting;Elsa Callén;Nancy Wong;Hua Tang Chen

1892
Citations
Genomic instability in mice lacking histone H2AX.

Arkady Celeste;Simone Petersen;Peter J. Romanienko;Oscar Fernandez-Capetillo

1725
Citations
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

Arnab Ray Chaudhuri;Arnab Ray Chaudhuri;André Nussenzweig

1374
Citations
H2AX: the histone guardian of the genome.

Oscar Fernandez-Capetillo;Alicia Lee;Michel Nussenzweig;André Nussenzweig

1289
Citations
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

Arkady Celeste;Oscar Fernandez-Capetillo;Michael J. Kruhlak;Duane R. Pilch

1275
Citations
Endogenous DNA Damage as a Source of Genomic Instability in Cancer

Anthony Tubbs;André Nussenzweig

1255
Citations
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

Derrick J Rossi;David Bryder;David Bryder;Jun Seita;Andre Nussenzweig

1254
Citations
Replication fork stability confers chemoresistance in BRCA-deficient cells

Arnab Ray Chaudhuri;Elsa Callen;Xia Ding;Ewa Gogola

850
Citations
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.

Oscar Fernandez-Capetillo;Hua Tang Chen;Arkady Celeste;Irene Ward

839
Citations
MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

Zhenkun Lou;Katherine Minter-Dykhouse;Sonia Franco;Monica Gostissa

806
Citations
Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

A Nussenzweig;C Chen;V da Costa Soares;M Sanchez

795
Citations
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation.

Michael J. Difilippantonio;Jie Zhu;Hua Tang Chen;Eric Meffre

695
Citations
H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility

Arkady Celeste;Simone Difilippantonio;Michael J. Difilippantonio;Oscar Fernandez-Capetillo

675
Citations
H2AX Is Required for Chromatin Remodeling and Inactivation of Sex Chromosomes in Male Mouse Meiosis

Oscar Fernandez-Capetillo;Shantha K. Mahadevaiah;Arkady Celeste;Peter J. Romanienko

668
Citations
Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes

Takahisa Furuta;Haruyuki Takemura;Zhi Yong Liao;Gregory J. Aune

644
Citations
Silencing of unsynapsed meiotic chromosomes in the mouse.

James M A Turner;Shantha K Mahadevaiah;Oscar Fernandez-Capetillo;André Nussenzweig

613
Citations
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

Michael J. Kruhlak;Arkady Celeste;Graham Dellaire;Oscar Fernandez-Capetillo

596
Citations
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

Simone Petersen;Rafael Casellas;Bernardo Reina-San-Martin;Hua Tang Chen

587
Citations
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo

Almudena R. Ramiro;Mila Jankovic;Thomas Eisenreich;Thomas Eisenreich;Simone Difilippantonio

586
Citations
Characteristics of γ-H2AX foci at DNA double-strand breaks sites

Duane R Pilch;Olga A Sedelnikova;Christophe Redon;Arkady Celeste

576
Citations

Frequent Co-Authors

Michel C. Nussenzweig Rockefeller University

Elsa Callen National Institutes of Health

Oscar Fernandez-Capetillo Spanish National Cancer Research Centre

Michael J. Kruhlak National Institutes of Health

Mila Jankovic Rockefeller University

Thomas Ried National Institutes of Health

Davide F. Robbiani Universita della Svizzera Italiana

Barry P. Sleckman University of Alabama at Birmingham

Gloria C. Li Memorial Sloan Kettering Cancer Center

William M. Bonner National Institutes of Health

External Links

Personal website of André Nussenzweig

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